Taf1c TATA-box binding protein associated factor, RNA polymerase I, C [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Taf1cprovided by MGI
Official Full Name: TATA-box binding protein associated factor, RNA polymerase I, Cprovided by MGI
Primary source: MGI:MGI:109576
See related: Ensembl:ENSMUSG00000031832 AllianceGenome:MGI:109576
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tafi95; mTAFI95
Summary: Predicted to enable RNA polymerase I core promoter sequence-specific DNA binding activity and RNA polymerase I general transcription initiation factor activity. Predicted to act upstream of or within transcription by RNA polymerase I. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of RNA polymerase I transcription regulator complex. Predicted to be active in fibrillar center. Is expressed in limb and limb mesenchyme. Orthologous to human TAF1C (TATA-box binding protein associated factor, RNA polymerase I subunit C). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in thymus adult (RPKM 32.3), ovary adult (RPKM 15.5) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 E1; 8 68.02 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (120324713..120331945, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (119597974..119605206, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase I core promoter sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase I core promoter sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase I general transcription initiation factor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within transcription by RNA polymerase I	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of RNA polymerase I transcription regulator complex	TAS Traceable Author Statement more info	PubMed
part_of RNA polymerase transcription factor SL1 complex	IPI Inferred from Physical Interaction more info	PubMed
part_of RNA polymerase transcription factor SL1 complex	ISO Inferred from Sequence Orthology more info
is_active_in fibrillar center	IBA Inferred from Biological aspect of Ancestor more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: TATA box-binding protein-associated factor RNA polymerase I subunit C

Names: RNA polymerase I-specific TBP-associated factor 95 kDa; TATA box binding protein (Tbp)-associated factor, RNA polymerase I, C; TATA box binding protein (Tbp)-associated factor, RNA polymerase I, C; transcription factor TAFI95; TATA box-binding protein-associated factor 1C; TBP-associated factor 1C; TBP-associated factor RNA polymerase I 95 kDa; transcription factor TAFI95; transcription initiation factor SL1/TIF-IB subunit C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001378901.1 → NP_001365830.1 TATA box-binding protein-associated factor RNA polymerase I subunit C isoform 2

Status: VALIDATED

Source sequence(s)

AC104882
NM_021441.3 → NP_067416.2 TATA box-binding protein-associated factor RNA polymerase I subunit C isoform 1

See identical proteins and their annotated locations for NP_067416.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AC104882

Consensus CDS

CCDS40493.1

UniProtKB/Swiss-Prot

P97359, Q3U3B6, Q6PDZ2, Q8BN54

UniProtKB/TrEMBL

Q3U0N4

Related

ENSMUSP00000090789.7, ENSMUST00000093099.13