U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Taf1b TATA-box binding protein associated factor, RNA polymerase I, B [ Mus musculus (house mouse) ]

Gene ID: 21340, updated on 21-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Taf1bprovided by MGI
Official Full Name
TATA-box binding protein associated factor, RNA polymerase I, Bprovided by MGI
Primary source
MGI:MGI:109577
See related
Ensembl:ENSMUSG00000059669 AllianceGenome:MGI:109577
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p63; TAFI68; Tafi86; 4930408G01Rik; A230108M10Rik
Summary
Predicted to enable RNA polymerase I core promoter sequence-specific DNA binding activity. Predicted to be involved in RNA polymerase I preinitiation complex assembly and nucleolar large rRNA transcription by RNA polymerase I. Predicted to act upstream of or within transcription by RNA polymerase I. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of RNA polymerase I core factor complex and RNA polymerase transcription factor SL1 complex. Is expressed in heart and limb. Orthologous to human TAF1B (TATA-box binding protein associated factor, RNA polymerase I subunit B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 7.5), CNS E14 (RPKM 6.5) and 24 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
12 A1.3; 12 8.49 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (24548580..24608570)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (24498581..24558571)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene nuclear encoded tRNA glutamic acid 14 (anticodon CTC) Neighboring gene STARR-seq mESC enhancer starr_31751 Neighboring gene actin related protein 2/3 complex, subunit 5 pseudogene Neighboring gene STARR-seq mESC enhancer starr_31752 Neighboring gene STARR-positive B cell enhancer mm9_chr12:25256927-25257228 Neighboring gene grainyhead like transcription factor 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:25278331-25278514 Neighboring gene cytochrome c oxidase subunit VIIa polypeptide 2-like pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Identification of novel nuclear protein interactions with the N-terminal part of filamin A. Qiu H, et al. Biosci Biotechnol Biochem, 2011. PMID 21228480
  2. Expression, cloning and cDNA sequence of a fibroblast serum-regulated gene encoding a putative actin-associated protein (p27). Almendral JM, et al. Exp Cell Res, 1989 Apr. PMID 2924801
  3. Ribosomal DNA promoter recognition is determined in vivo by cooperation between UBTF1 and SL1 and is compromised in the UBTF-E210K neuroregression syndrome. Tremblay MG, et al. PLoS Genet, 2022 Feb. PMID 35139074, Free PMC Article
  4. The nucleolus as a stress sensor: JNK2 inactivates the transcription factor TIF-IA and down-regulates rRNA synthesis. Mayer C, et al. Genes Dev, 2005 Apr 15. PMID 15805466, Free PMC Article
  5. Gene structure and evolution of Tieg3, a new member of the Tieg family of proteins. Wang Z, et al. Gene, 2004 Jan 21. PMID 14697507

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase I core promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase I core promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA polymerase I preinitiation complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in nucleolar large rRNA transcription by RNA polymerase I IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within transcription by RNA polymerase I TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of RNA polymerase I core factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase I core factor complex ISO
Inferred from Sequence Orthology
more info
  
part_of RNA polymerase I transcription regulator complex TAS
Traceable Author Statement
more info
 PubMed 
part_of RNA polymerase transcription factor SL1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase transcription factor SL1 complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
TATA box-binding protein-associated factor RNA polymerase I subunit B
Names
RNA polymerase I-specific TBP-associated factor 68 kDa
TATA box binding protein (Tbp)-associated factor, RNA polymerase I, B
TATA box-binding protein-associated factor 1B
TBP-associated factor 1B
TBP-associated factor RNA polymerase I 68
transcription factor TAFI68
transcription initiation factor SL1/TIF-IB subunit B

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020614.2 → NP_065639.2  TATA box-binding protein-associated factor RNA polymerase I subunit B

    See identical proteins and their annotated locations for NP_065639.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
    Source sequence(s)
    AC125067, AK131963, CK619940
    Consensus CDS
    CCDS36419.1
    UniProtKB/Swiss-Prot
    E9QJY7, P97358, Q08AT7, Q3V292, Q6NSS9
    Related
    ENSMUSP00000075339.8, ENSMUST00000075954.9
    Conserved Domains (1) summary
    pfam11781
    Location:10 → 39
    RRN7; RNA polymerase I-specific transcription initiation factor Rrn7

RNA

  1. NR_028341.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC125067, BC086643, CJ068630, CK619940, CN721617
    Related
    ENSMUST00000221372.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    24548580..24608570
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515051.2 → XP_006515114.1  TATA box-binding protein-associated factor RNA polymerase I subunit B isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97358.2 GenPept UniProtKB/Swiss-Prot:P97358

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous