Depp1 DEPP1 autophagy regulator [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Depp1provided by MGI
Official Full Name: DEPP1 autophagy regulatorprovided by MGI
Primary source: MGI:MGI:1918730
See related: Ensembl:ENSMUSG00000048489 AllianceGenome:MGI:1918730
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Depp; Fseg; 8430408G22Rik
Summary: Predicted to be involved in regulation of autophagy. Predicted to act upstream of or within autophagy. Located in mitochondrion. Is expressed in endothelium of renal artery and metanephros. Orthologous to human DEPP1 (DEPP1 autophagy regulator). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver adult (RPKM 61.7), liver E18 (RPKM 58.4) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 E3; 6 53.83 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (116627645..116629808)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (116650684..116652847)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hepatic overexpression of DEPP in mice promotes fatty acid oxidation and ketogenesis and suppresses lipogenesis and gluconeogenesis, which is partly mediated by FGF21 induced by elevated cellular ROS levels.
Title: DEPP/DEPP1/C10ORF10 regulates hepatic glucose and fat metabolism partly via ROS-induced FGF21.
DEPP is a novel insulin-regulatory molecule expressed abundantly in insulin-sensitive tissues including white adipose tissue and liver.
Title: Insulin-mediated regulation of decidual protein induced by progesterone (DEPP) in adipose tissue and liver.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within autophagy	IEA Inferred from Electronic Annotation more info
involved_in regulation of autophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of autophagy	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in peroxisome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein DEPP1

Names: decidual protein induced by progesterone; fat-specific expressed; fat-specific-expressed gene protein; protein DEPP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001166580.1 → NP_001160052.1 protein DEPP1

See identical proteins and their annotated locations for NP_001160052.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC160973, BC058515

Consensus CDS

CCDS51882.1

UniProtKB/Swiss-Prot

Q8BU66, Q8K2F3

Related

ENSMUSP00000136165.2, ENSMUST00000178241.4

Conserved Domains (1) summary

pfam15343
Location:25 → 205

DEPP; Decidual protein induced by progesterone family
NM_145980.2 → NP_666092.1 protein DEPP1

See identical proteins and their annotated locations for NP_666092.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript.

Source sequence(s)

AK078806, AK087284, BB683812

Consensus CDS

CCDS51882.1

UniProtKB/Swiss-Prot

Q8BU66, Q8K2F3

Related

ENSMUSP00000070203.6, ENSMUST00000067354.10

Conserved Domains (1) summary

pfam15343
Location:25 → 205

DEPP; Decidual protein induced by progesterone family