Fbxl21 F-box and leucine-rich repeat protein 21 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fbxl21provided by MGI
Official Full Name: F-box and leucine-rich repeat protein 21provided by MGI
Primary source: MGI:MGI:2442921
See related: Ensembl:ENSMUSG00000035509 AllianceGenome:MGI:2442921
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FBL3B; Psttm; FBXL3B; D630045D17Rik
Summary: Involved in entrainment of circadian clock by photoperiod and protein ubiquitination. Located in cytosol and nucleus. Part of SCF ubiquitin ligase complex. Is expressed in gonad; metanephros; nervous system; and stomach. Orthologous to human FBXL21P (F-box and leucine rich repeat protein 21, pseudogene). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 13 B1; 13 30.07 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (56670201..56685711)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (56522388..56537898)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The circadian E3 ligase FBXL21 regulates myoblast differentiation and sarcomere architecture via MYOZ1 ubiquitination and NFAT signaling.
Title: The circadian E3 ligase FBXL21 regulates myoblast differentiation and sarcomere architecture via MYOZ1 ubiquitination and NFAT signaling.
The GSK-3beta-FBXL21 Axis Contributes to Circadian TCAP Degradation and Skeletal Muscle Function.
Title: The GSK-3β-FBXL21 Axis Contributes to Circadian TCAP Degradation and Skeletal Muscle Function.
Study shows that FBXL21 ubiquitinates CRY1 and CRY2 and that, surprisingly, FBXL21 stabilizes CRYs. FBXL21 localizes predominantly in the cytosol, whereas FBXL3 is present in the nucleus.
Title: FBXL21 regulates oscillation of the circadian clock through ubiquitination and stabilization of cryptochromes.
FBXL21 plays a dual role: protecting CRY from FBXL3 degradation in the nucleus and promoting CRY degradation within the cytoplasm.
Title: Competing E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasm.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Chemically induced (ENU) (1)
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in entrainment of circadian clock by photoperiod	IBA Inferred from Biological aspect of Ancestor more info
involved_in entrainment of circadian clock by photoperiod	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within rhythmic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of SCF ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SCF ubiquitin ligase complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: F-box/LRR-repeat protein 21

Names: F-box and leucine-rich repeat protein 3B; F-box/LRR-repeat protein 3B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001346732.1 → NP_001333661.1 F-box/LRR-repeat protein 21 isoform 2

Status: VALIDATED

Source sequence(s)

AC132901, AK035290, AK079800

Consensus CDS

CCDS84026.1

UniProtKB/TrEMBL

G3X9Y3

Related

ENSMUSP00000112518.2, ENSMUST00000121871.8
NM_001359807.1 → NP_001346736.1 F-box/LRR-repeat protein 21 isoform 3

Status: VALIDATED

Source sequence(s)

AK079800, BE946365

Consensus CDS

CCDS88461.1

UniProtKB/TrEMBL

A0A0R4J1M5

Related

ENSMUSP00000112714.2, ENSMUST00000121095.8

Conserved Domains (1) summary

pfam12937
Location:68 → 111

F-box-like; F-box-like
NM_178674.5 → NP_848789.2 F-box/LRR-repeat protein 21 isoform 1

See identical proteins and their annotated locations for NP_848789.2

Status: VALIDATED

Source sequence(s)

AK035290, AK079800, AK085598

Consensus CDS

CCDS26563.1

UniProtKB/Swiss-Prot

B2RSN8, Q8BFZ4, Q8BIJ8, Q8BIW5

Related

ENSMUSP00000035248.7, ENSMUST00000045428.7

Conserved Domains (3) summary

cd09293
Location:333 → 398

AMN1; Antagonist of mitotic exit network protein 1

sd00034
Location:180 → 205

LRR_AMN1; leucine-rich repeat [structural motif]

pfam12937
Location:42 → 85

F-box-like; F-box-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

56670201..56685711

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017315478.3 → XP_017170967.1 F-box/LRR-repeat protein 21 isoform X2

Conserved Domains (1) summary

pfam12937
Location:68 → 111

F-box-like
XM_011244507.4 → XP_011242809.1 F-box/LRR-repeat protein 21 isoform X2

Conserved Domains (1) summary

pfam12937
Location:68 → 111

F-box-like
XM_011244506.4 → XP_011242808.1 F-box/LRR-repeat protein 21 isoform X1

Conserved Domains (1) summary

pfam12937
Location:68 → 111

F-box-like