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T2 brachyury 2 [ Mus musculus (house mouse) ]

Gene ID: 21331, updated on 8-Feb-2024

Summary

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Official Symbol
T2provided by MGI
Official Full Name
brachyury 2provided by MGI
Primary source
MGI:MGI:104658
See related
Ensembl:ENSMUSG00000058159 AllianceGenome:MGI:104658
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
brachyury2
Summary
Acts upstream of or within notochord formation. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in ovary adult (RPKM 1.1), lung adult (RPKM 0.9) and 12 other tissues See more
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Genomic context

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Location:
17 A1; 17 4.92 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (8574590..8661323)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (8355760..8422728)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930506C21 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:8503785-8503968 Neighboring gene SFT2 domain containing 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:8564858-8564967 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:8565311-8565494 Neighboring gene STARR-positive B cell enhancer ABC_E4191 Neighboring gene predicted gene, 46592 Neighboring gene proline rich 18 Neighboring gene STARR-seq mESC enhancer starr_41764 Neighboring gene protein FAM32A pseudogene Neighboring gene predicted gene, 16702 Neighboring gene STARR-seq mESC enhancer starr_41765 Neighboring gene T (brachyury) promoter Neighboring gene ribosomal protein L15 pseudogene Neighboring gene predicted gene, 34036 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:8661752-8661935 Neighboring gene brachyury, T-box transcription factor T Neighboring gene STARR-seq mESC enhancer starr_41767 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:8755802-8755955 Neighboring gene phosphodiesterase 10A Neighboring gene predicted gene 15425 Neighboring gene predicted gene 17087

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mouse Brachyury the Second (T2) is a gene next to classical T and a candidate gene for tct. Rennebeck G, et al. Genetics, 1998 Nov. PMID 9799264, Free PMC Article
  2. Tint maps to mouse chromosome 6 and may interact with a notochordal enhancer of Brachyury. Wu JI, et al. Genetics, 2007 Oct. PMID 17954925, Free PMC Article
  3. Is there a Brachyury the Second? Analysis of a transgenic mutation involved in notochord maintenance in mice. Rennebeck GM, et al. Dev Biol, 1995 Nov. PMID 7589801
  4. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Mural RJ, et al. Science, 2002 May 31. PMID 12040188
  5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within notochord formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
brachyury 2
Names
brachyury the second

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161832.1 → NP_001155304.1  brachyury 2

    See identical proteins and their annotated locations for NP_001155304.1

    Status: PROVISIONAL

    Source sequence(s)
    AC154579, AC164431
    Consensus CDS
    CCDS88987.1
    UniProtKB/TrEMBL
    A0A338P791
    Related
    ENSMUSP00000156321.2, ENSMUST00000163578.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    8574590..8661323
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160447.1 → XP_036016340.1  brachyury 2 isoform X3

    UniProtKB/TrEMBL
    A0A3Q4EGG8
    Related
    ENSMUSP00000157191.2, ENSMUST00000234809.2

  2. XM_036160444.1 → XP_036016337.1  brachyury 2 isoform X1

    Conserved Domains (1) summary
    cd20202
    Location:41 → 219
    T-box_TBXT; DNA-binding domain of T-box transcription factor T and related T-box proteins

  3. XM_036160445.1 → XP_036016338.1  brachyury 2 isoform X2

    UniProtKB/Swiss-Prot
    P20293
    UniProtKB/TrEMBL
    Q78ZW9
    Conserved Domains (1) summary
    cd20202
    Location:41 → 219
    T-box_TBXT; DNA-binding domain of T-box transcription factor T and related T-box proteins

  4. XM_036160449.1 → XP_036016342.1  brachyury 2 isoform X4

  5. XM_036160448.1 → XP_036016341.1  brachyury 2 isoform X4

RNA

  1. XR_004939491.1 RNA Sequence

  2. XR_004939489.1 RNA Sequence

  3. XR_004939490.1 RNA Sequence

  4. XR_004939496.1 RNA Sequence

  5. XR_004939498.1 RNA Sequence

  6. XR_004939497.1 RNA Sequence

  7. XR_004939487.1 RNA Sequence

  8. XR_004939492.1 RNA Sequence

  9. XR_004939493.1 RNA Sequence

  10. XR_004939494.1 RNA Sequence

  11. XR_004939495.1 RNA Sequence

  12. XR_004939502.1 RNA Sequence

  13. XR_004939488.1 RNA Sequence

  14. XR_004939504.1 RNA Sequence

  15. XR_004939500.1 RNA Sequence

    Related
    ENSMUST00000169635.3

  16. XR_004939499.1 RNA Sequence

  17. XR_004939501.1 RNA Sequence

  18. XR_004939503.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_013682.1: Suppressed sequence

    Description
    NM_013682.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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