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Cdkl3 cyclin dependent kinase like 3 [ Mus musculus (house mouse) ]

Gene ID: 213084, updated on 11-Apr-2024

Summary

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Official Symbol
Cdkl3provided by MGI
Official Full Name
cyclin dependent kinase like 3provided by MGI
Primary source
MGI:MGI:2388268
See related
Ensembl:ENSMUSG00000020389 AllianceGenome:MGI:2388268
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B230379H01Rik
Summary
Predicted to enable cyclin-dependent protein serine/threonine kinase activity. Acts upstream of or within dendrite extension; negative regulation of axon extension; and positive regulation of dendrite morphogenesis. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including brain; genitourinary system; liver; lung; and spleen. Orthologous to human CDKL3 (cyclin dependent kinase like 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 12.9), CNS E18 (RPKM 1.4) and 5 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B1.3; 11 31.85 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (51891694..51980605)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (52000842..52089778)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene CDKN2A interacting protein N-terminal like Neighboring gene predicted gene, 26061 Neighboring gene ubiquitin-conjugating enzyme E2B Neighboring gene STARR-seq mESC enhancer starr_29438 Neighboring gene STARR-seq mESC enhancer starr_29439 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:51879429-51879612 Neighboring gene STARR-positive B cell enhancer ABC_E8875 Neighboring gene STARR-positive B cell enhancer ABC_E10674 Neighboring gene protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform Neighboring gene predicted gene, 30631 Neighboring gene microRNA 3061

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Inactivition of CDKL3 mildly inhibits proliferation of cells at VZ/SVZ in brain. Liu Z, et al. Neurol Sci, 2015 Feb. PMID 25270654
  2. Non-syndromic mild mental retardation candidate gene CDKL3 regulates neuronal morphogenesis. Liu Z, et al. Neurobiol Dis, 2010 Sep. PMID 20347982
  3. Inactivation of the CDKL3 gene at 5q31.1 by a balanced t(X;5) translocation associated with nonspecific mild mental retardation. Dubos A, et al. Am J Med Genet A, 2008 May 15. PMID 18412109
  4. The TAF10-containing TFIID and SAGA transcriptional complexes are dispensable for early somitogenesis in the mouse embryo. Bardot P, et al. Development, 2017 Oct 15. PMID 28893950, Free PMC Article
  5. The sperm-associated antigen 6 interactome and its role in spermatogenesis. Liu Y, et al. Reproduction, 2019 Aug. PMID 31146259, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results indicated that CDKL3 may be involved in proliferation of cells surrounding the brain ventricle where neuronal progenitor cells are enriched during the late embryo st
    Title: Inactivition of CDKL3 mildly inhibits proliferation of cells at VZ/SVZ in brain.
  2. CDKL3 is involved in neuronal morphogenesis during development.
    Title: Non-syndromic mild mental retardation candidate gene CDKL3 regulates neuronal morphogenesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC28957

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in dendrite extension IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within dendrite extension IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within dendrite extension ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of axon extension IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of axon extension IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of axon extension ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of dendrite morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of dendrite morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cyclin-dependent kinase-like 3
NP_001160125.1
NP_001160126.1
NP_001160127.1
NP_001160128.1
NP_001160129.1
NP_001350405.1
NP_722480.3
XP_006532830.1
XP_006532831.1
XP_006532832.1
XP_006532833.1
XP_006532836.1
XP_011247165.1
XP_011247170.1
XP_011247172.1
XP_011247173.1
XP_011247174.1
XP_011247176.1
XP_011247180.1
XP_011247183.1
XP_030101618.1
XP_030101620.1
XP_030101622.1
XP_030101623.1
XP_030101624.1
XP_036012392.1
XP_036012393.1
XP_036012394.1
XP_036012395.1
XP_036012396.1
XP_036012397.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166653.1 → NP_001160125.1  cyclin-dependent kinase-like 3 isoform 1

    See identical proteins and their annotated locations for NP_001160125.1

    Status: VALIDATED

    Source sequence(s)
    AK045356, AK046394, AK050990, BB759970
    Consensus CDS
    CCDS48789.1
    UniProtKB/TrEMBL
    B1AU43, F2Z3Z6
    Related
    ENSMUSP00000104708.3, ENSMUST00000109080.9
    Conserved Domains (1) summary
    cl21453
    Location:2 → 286
    PKc_like; Protein Kinases, catalytic domain

  2. NM_001166654.1 → NP_001160126.1  cyclin-dependent kinase-like 3 isoform 3

    See identical proteins and their annotated locations for NP_001160126.1

    Status: VALIDATED

    Source sequence(s)
    AK046394, AL669920
    Consensus CDS
    CCDS48790.1
    UniProtKB/TrEMBL
    F2Z3Z6
    Related
    ENSMUSP00000112477.2, ENSMUST00000121591.8
    Conserved Domains (1) summary
    cl21453
    Location:2 → 286
    PKc_like; Protein Kinases, catalytic domain

  3. NM_001166655.1 → NP_001160127.1  cyclin-dependent kinase-like 3 isoform 4

    See identical proteins and their annotated locations for NP_001160127.1

    Status: VALIDATED

    Source sequence(s)
    AK046394, AK050990
    Consensus CDS
    CCDS48791.1
    UniProtKB/Swiss-Prot
    Q8BLF2
    Related
    ENSMUSP00000104706.2, ENSMUST00000109078.8
    Conserved Domains (1) summary
    cl21453
    Location:2 → 286
    PKc_like; Protein Kinases, catalytic domain

  4. NM_001166656.1 → NP_001160128.1  cyclin-dependent kinase-like 3 isoform 5

    See identical proteins and their annotated locations for NP_001160128.1

    Status: VALIDATED

    Source sequence(s)
    AK046394, AK050990, AK078804
    Consensus CDS
    CCDS48788.1
    UniProtKB/TrEMBL
    F2Z3Z6
    Related
    ENSMUSP00000065128.7, ENSMUST00000063321.13
    Conserved Domains (2) summary
    smart00220
    Location:4 → 286
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:2 → 286
    PKc_like; Protein Kinases, catalytic domain

  5. NM_001166657.1 → NP_001160129.1  cyclin-dependent kinase-like 3 isoform 6

    See identical proteins and their annotated locations for NP_001160129.1

    Status: VALIDATED

    Source sequence(s)
    AK046394, AK050990
    Consensus CDS
    CCDS48792.1
    UniProtKB/Swiss-Prot
    Q8BLF2
    Related
    ENSMUSP00000104704.2, ENSMUST00000109076.2
    Conserved Domains (2) summary
    smart00220
    Location:4 → 286
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:2 → 286
    PKc_like; Protein Kinases, catalytic domain

  6. NM_001363476.1 → NP_001350405.1  cyclin-dependent kinase-like 3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL669920
    Consensus CDS
    CCDS48791.1
    Conserved Domains (1) summary
    cl21453
    Location:2 → 286
    PKc_like; Protein Kinases, catalytic domain

  7. NM_153785.4 → NP_722480.3  cyclin-dependent kinase-like 3 isoform 2

    See identical proteins and their annotated locations for NP_722480.3

    Status: VALIDATED

    Source sequence(s)
    AK045356, AK046394, AL669920
    Consensus CDS
    CCDS24665.1
    UniProtKB/Swiss-Prot
    A2ACR7, A2ACR8, A2ACR9, A2ACS0, A2ACS1, Q5M6W2, Q8BKR2, Q8BL49, Q8BLF2, Q8BLN9, Q8BVE0, Q8K134
    UniProtKB/TrEMBL
    F2Z3Z6
    Related
    ENSMUSP00000064315.5, ENSMUST00000063303.11
    Conserved Domains (1) summary
    cl21453
    Location:2 → 286
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. NR_156698.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL669920, AL935177

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    51891694..51980605
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532773.4 → XP_006532836.1  cyclin-dependent kinase-like 3 isoform X1

    See identical proteins and their annotated locations for XP_006532836.1

    UniProtKB/TrEMBL
    F2Z3Z6
    Conserved Domains (1) summary
    cl21453
    Location:2 → 286
    PKc_like; Protein Kinases, catalytic domain

  2. XM_011248868.3 → XP_011247170.1  cyclin-dependent kinase-like 3 isoform X3

    See identical proteins and their annotated locations for XP_011247170.1

    UniProtKB/TrEMBL
    F2Z3Z6
    Conserved Domains (1) summary
    cl21453
    Location:2 → 286
    PKc_like; Protein Kinases, catalytic domain

  3. XM_011248863.3 → XP_011247165.1  cyclin-dependent kinase-like 3 isoform X2

    UniProtKB/TrEMBL
    F2Z3Z6
    Conserved Domains (1) summary
    cl21453
    Location:2 → 286
    PKc_like; Protein Kinases, catalytic domain

  4. XM_011248878.1 → XP_011247180.1  cyclin-dependent kinase-like 3 isoform X8

    See identical proteins and their annotated locations for XP_011247180.1

    UniProtKB/TrEMBL
    F2Z3Z6
    Conserved Domains (1) summary
    cl21453
    Location:2 → 286
    PKc_like; Protein Kinases, catalytic domain

  5. XM_030245762.1 → XP_030101622.1  cyclin-dependent kinase-like 3 isoform X9

    UniProtKB/TrEMBL
    F2Z3Z6
    Related
    ENSMUSP00000123279.2, ENSMUST00000143228.8
    Conserved Domains (1) summary
    cl21453
    Location:2 → 286
    PKc_like; Protein Kinases, catalytic domain

  6. XM_011248874.2 → XP_011247176.1  cyclin-dependent kinase-like 3 isoform X6

    See identical proteins and their annotated locations for XP_011247176.1

    UniProtKB/TrEMBL
    F2Z3Z6
    Conserved Domains (1) summary
    cl21453
    Location:2 → 286
    PKc_like; Protein Kinases, catalytic domain

  7. XM_030245758.1 → XP_030101618.1  cyclin-dependent kinase-like 3 isoform X7

    UniProtKB/TrEMBL
    F2Z3Z6
    Conserved Domains (1) summary
    cl21453
    Location:2 → 286
    PKc_like; Protein Kinases, catalytic domain

  8. XM_006532768.2 → XP_006532831.1  cyclin-dependent kinase-like 3 isoform X1

    See identical proteins and their annotated locations for XP_006532831.1

    UniProtKB/TrEMBL
    F2Z3Z6
    Conserved Domains (1) summary
    cl21453
    Location:2 → 286
    PKc_like; Protein Kinases, catalytic domain

  9. XM_006532767.4 → XP_006532830.1  cyclin-dependent kinase-like 3 isoform X1

    See identical proteins and their annotated locations for XP_006532830.1

    UniProtKB/TrEMBL
    F2Z3Z6
    Conserved Domains (1) summary
    cl21453
    Location:2 → 286
    PKc_like; Protein Kinases, catalytic domain

  10. XM_006532770.2 → XP_006532833.1  cyclin-dependent kinase-like 3 isoform X1

    See identical proteins and their annotated locations for XP_006532833.1

    UniProtKB/TrEMBL
    F2Z3Z6
    Conserved Domains (1) summary
    cl21453
    Location:2 → 286
    PKc_like; Protein Kinases, catalytic domain

  11. XM_036156499.1 → XP_036012392.1  cyclin-dependent kinase-like 3 isoform X1

    UniProtKB/TrEMBL
    F2Z3Z6
    Conserved Domains (1) summary
    cl21453
    Location:2 → 286
    PKc_like; Protein Kinases, catalytic domain

  12. XM_006532769.4 → XP_006532832.1  cyclin-dependent kinase-like 3 isoform X1

    See identical proteins and their annotated locations for XP_006532832.1

    UniProtKB/TrEMBL
    F2Z3Z6
    Conserved Domains (1) summary
    cl21453
    Location:2 → 286
    PKc_like; Protein Kinases, catalytic domain

  13. XM_036156500.1 → XP_036012393.1  cyclin-dependent kinase-like 3 isoform X3

    UniProtKB/TrEMBL
    F2Z3Z6
    Conserved Domains (1) summary
    cl21453
    Location:2 → 286
    PKc_like; Protein Kinases, catalytic domain

  14. XM_011248870.4 → XP_011247172.1  cyclin-dependent kinase-like 3 isoform X4

    See identical proteins and their annotated locations for XP_011247172.1

    UniProtKB/TrEMBL
    F2Z3Z6
    Conserved Domains (1) summary
    cl21453
    Location:2 → 286
    PKc_like; Protein Kinases, catalytic domain

  15. XM_036156501.1 → XP_036012394.1  cyclin-dependent kinase-like 3 isoform X8

    UniProtKB/TrEMBL
    F2Z3Z6
    Conserved Domains (1) summary
    cl21453
    Location:2 → 286
    PKc_like; Protein Kinases, catalytic domain

  16. XM_030245760.1 → XP_030101620.1  cyclin-dependent kinase-like 3 isoform X8

    UniProtKB/TrEMBL
    F2Z3Z6
    Conserved Domains (1) summary
    cl21453
    Location:2 → 286
    PKc_like; Protein Kinases, catalytic domain

  17. XM_011248881.2 → XP_011247183.1  cyclin-dependent kinase-like 3 isoform X9

    See identical proteins and their annotated locations for XP_011247183.1

    UniProtKB/TrEMBL
    F2Z3Z6
    Conserved Domains (1) summary
    cl21453
    Location:2 → 286
    PKc_like; Protein Kinases, catalytic domain

  18. XM_011248871.3 → XP_011247173.1  cyclin-dependent kinase-like 3 isoform X4

    See identical proteins and their annotated locations for XP_011247173.1

    UniProtKB/TrEMBL
    F2Z3Z6
    Conserved Domains (1) summary
    cl21453
    Location:2 → 286
    PKc_like; Protein Kinases, catalytic domain

  19. XM_011248872.3 → XP_011247174.1  cyclin-dependent kinase-like 3 isoform X5

    See identical proteins and their annotated locations for XP_011247174.1

    UniProtKB/TrEMBL
    B1AU43, F2Z3Z6
    Conserved Domains (1) summary
    cl21453
    Location:2 → 286
    PKc_like; Protein Kinases, catalytic domain

  20. XM_030245764.2 → XP_030101624.1  cyclin-dependent kinase-like 3 isoform X8

    UniProtKB/TrEMBL
    F2Z3Z6
    Related
    ENSMUSP00000104709.3, ENSMUST00000109081.9
    Conserved Domains (1) summary
    cl21453
    Location:2 → 286
    PKc_like; Protein Kinases, catalytic domain

  21. XM_036156504.1 → XP_036012397.1  cyclin-dependent kinase-like 3 isoform X8

    UniProtKB/TrEMBL
    F2Z3Z6
    Conserved Domains (1) summary
    cl21453
    Location:2 → 286
    PKc_like; Protein Kinases, catalytic domain

  22. XM_036156502.1 → XP_036012395.1  cyclin-dependent kinase-like 3 isoform X6

    UniProtKB/TrEMBL
    F2Z3Z6
    Conserved Domains (1) summary
    cl21453
    Location:2 → 286
    PKc_like; Protein Kinases, catalytic domain

  23. XM_036156503.1 → XP_036012396.1  cyclin-dependent kinase-like 3 isoform X10

    UniProtKB/Swiss-Prot
    A2ACR7, A2ACR8, A2ACR9, A2ACS0, A2ACS1, Q5M6W2, Q8BKR2, Q8BL49, Q8BLF2, Q8BLN9, Q8BVE0, Q8K134
    UniProtKB/TrEMBL
    F2Z3Z6
    Conserved Domains (1) summary
    cl21453
    Location:2 → 286
    PKc_like; Protein Kinases, catalytic domain

  24. XM_030245763.2 → XP_030101623.1  cyclin-dependent kinase-like 3 isoform X10

    UniProtKB/Swiss-Prot
    A2ACR7, A2ACR8, A2ACR9, A2ACS0, A2ACS1, Q5M6W2, Q8BKR2, Q8BL49, Q8BLF2, Q8BLN9, Q8BVE0, Q8K134
    UniProtKB/TrEMBL
    F2Z3Z6
    Conserved Domains (1) summary
    cl21453
    Location:2 → 286
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_004936900.1 RNA Sequence

  2. XR_003949370.1 RNA Sequence

  3. XR_004936901.1 RNA Sequence

  4. XR_004936902.1 RNA Sequence

  5. XR_004936906.1 RNA Sequence

  6. XR_004936905.1 RNA Sequence

  7. XR_004936907.1 RNA Sequence

  8. XR_004936908.1 RNA Sequence

  9. XR_879548.1 RNA Sequence

  10. XR_879549.1 RNA Sequence

  11. XR_003949373.1 RNA Sequence

  12. XR_004936904.1 RNA Sequence

  13. XR_879545.1 RNA Sequence

  14. XR_879546.1 RNA Sequence

  15. XR_879553.1 RNA Sequence

  16. XR_879554.2 RNA Sequence

  17. XR_004936909.1 RNA Sequence

  18. XR_003949374.2 RNA Sequence

  19. XR_003949379.2 RNA Sequence

  20. XR_004936903.1 RNA Sequence

  21. XR_003949375.2 RNA Sequence

  22. XR_003949378.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BLF2.2 GenPept UniProtKB/Swiss-Prot:Q8BLF2

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