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Hycc2 hyccin PI4KA lipid kinase complex subunit 2 [ Mus musculus (house mouse) ]

Gene ID: 213056, updated on 11-Apr-2024

Summary

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Official Symbol
Hycc2provided by MGI
Official Full Name
hyccin PI4KA lipid kinase complex subunit 2provided by MGI
Primary source
MGI:MGI:1098784
See related
Ensembl:ENSMUSG00000038174 AllianceGenome:MGI:1098784
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fam126b; D1Ertd53e; D630010C10; C130065N10Rik
Summary
Predicted to be involved in phosphatidylinositol phosphate biosynthetic process and protein localization to plasma membrane. Predicted to be located in cytoplasm and membrane. Predicted to be active in plasma membrane. Orthologous to human FAM126B (family with sequence similarity 126 member B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cortex adult (RPKM 5.3), cerebellum adult (RPKM 5.2) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See Hycc2 in Genome Data Viewer
Location:
1 C1.3; 1 29.12 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (58561965..58625492, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (58522806..58586333, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:58501960-58502147 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:58502340-58502523 Neighboring gene peptidylprolyl isomerase (cyclophilin)-like 3 Neighboring gene Ngg1 interacting factor 3-like 1 (S. pombe) Neighboring gene predicted gene, 23966 Neighboring gene origin recognition complex, subunit 2 Neighboring gene STARR-seq mESC enhancer starr_01014 Neighboring gene STARR-positive B cell enhancer ABC_E3277 Neighboring gene STARR-seq mESC enhancer starr_01015 Neighboring gene predicted gene 15834 Neighboring gene STARR-positive B cell enhancer ABC_E10012 Neighboring gene NADH:ubiquinone oxidoreductase subunit B3 Neighboring gene STARR-seq mESC enhancer starr_01016 Neighboring gene Fanconi anemia, complementation group L pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  2. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in phosphatidylinositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
hyccin 2
Names
family with sequence similarity 126, member B
protein FAM126B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310598.1 → NP_001297527.1  hyccin 2 isoform a

    See identical proteins and their annotated locations for NP_001297527.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC118698, AK168372, CA556879
    Consensus CDS
    CCDS78588.1
    UniProtKB/Swiss-Prot
    Q8C729
    Related
    ENSMUSP00000095331.4, ENSMUST00000097724.10
    Conserved Domains (1) summary
    pfam09790
    Location:22 → 330
    Hyccin

  2. NM_001310599.1 → NP_001297528.1  hyccin 2 isoform b

    See identical proteins and their annotated locations for NP_001297528.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AC118698, AK052638, BY265998
    Consensus CDS
    CCDS14976.1
    UniProtKB/Swiss-Prot
    Q3UMY7, Q6NV64, Q8C729
    Related
    ENSMUSP00000038718.8, ENSMUST00000038372.14
    Conserved Domains (1) summary
    pfam09790
    Location:22 → 330
    Hyccin

  3. NM_172513.3 → NP_766101.3  hyccin 2 isoform b

    See identical proteins and their annotated locations for NP_766101.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AC118698
    Consensus CDS
    CCDS14976.1
    UniProtKB/Swiss-Prot
    Q3UMY7, Q6NV64, Q8C729
    Related
    ENSMUSP00000123728.2, ENSMUST00000161600.8
    Conserved Domains (1) summary
    pfam09790
    Location:22 → 330
    Hyccin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    58561965..58625492 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252754.2 → XP_030108614.1  hyccin 2 isoform X2

    UniProtKB/Swiss-Prot
    Q3UMY7, Q6NV64, Q8C729
    Conserved Domains (1) summary
    pfam09790
    Location:22 → 330
    Hyccin

  2. XM_017319657.3 → XP_017175146.1  hyccin 2 isoform X2

    UniProtKB/Swiss-Prot
    Q3UMY7, Q6NV64, Q8C729
    Conserved Domains (1) summary
    pfam09790
    Location:22 → 330
    Hyccin

  3. XM_006495832.4 → XP_006495895.1  hyccin 2 isoform X1

    See identical proteins and their annotated locations for XP_006495895.1

    UniProtKB/Swiss-Prot
    Q8C729
    Conserved Domains (1) summary
    pfam09790
    Location:22 → 330
    Hyccin

  4. XM_017319658.3 → XP_017175147.1  hyccin 2 isoform X3

    Conserved Domains (1) summary
    pfam09790
    Location:1 → 186
    Hyccin

  5. XM_006495833.4 → XP_006495896.1  hyccin 2 isoform X1

    See identical proteins and their annotated locations for XP_006495896.1

    UniProtKB/Swiss-Prot
    Q8C729
    Conserved Domains (1) summary
    pfam09790
    Location:22 → 330
    Hyccin
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C729.1 GenPept UniProtKB/Swiss-Prot:Q8C729

Gene LinkOut

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