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Abhd10 abhydrolase domain containing 10 [ Mus musculus (house mouse) ]

Gene ID: 213012, updated on 5-Mar-2024

Summary

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Official Symbol
Abhd10provided by MGI
Official Full Name
abhydrolase domain containing 10provided by MGI
Primary source
MGI:MGI:2442422
See related
Ensembl:ENSMUSG00000033157 AllianceGenome:MGI:2442422
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
This gene encodes a mitochondrially-localized enzyme that acts as a hydrolase. The encoded protein removes glucuronide from mycophenolic acid acyl-glucuronide. There are two pseudogenes for this gene on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Expression
Ubiquitous expression in cerebellum adult (RPKM 7.3), CNS E18 (RPKM 7.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 B5; 16 30.04 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (45550088..45563355, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (45729725..45742955, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40918 Neighboring gene transmembrane serine protease 7 Neighboring gene STARR-seq mESC enhancer starr_40919 Neighboring gene STARR-seq mESC enhancer starr_40920 Neighboring gene transgelin 3 Neighboring gene STARR-seq mESC enhancer starr_40921 Neighboring gene pleckstrin homology like domain, family B, member 2 Neighboring gene STARR-seq mESC enhancer starr_40922 Neighboring gene predicted gene 15638 Neighboring gene phosphatidylinositol-specific phospholipase C, X domain containing 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:46006394-46006690 Neighboring gene STARR-positive B cell enhancer ABC_E4173

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Elk-3 target Abhd10 ameliorates hepatotoxic injury and fibrosis in alcoholic liver disease. Li TZ, et al. Commun Biol, 2023 Jul 3. PMID 37400491, Free PMC Article
  2. ALS-linked mutant superoxide dismutase 1 (SOD1) alters mitochondrial protein composition and decreases protein import. Li Q, et al. Proc Natl Acad Sci U S A, 2010 Dec 7. PMID 21078990, Free PMC Article
  3. ABHD10 is an S-depalmitoylase affecting redox homeostasis through peroxiredoxin-5. Cao Y, et al. Nat Chem Biol, 2019 Dec. PMID 31740833, Free PMC Article
  4. Human α/β hydrolase domain containing 10 (ABHD10) is responsible enzyme for deglucuronidation of mycophenolic acid acyl-glucuronide in liver. Iwamura A, et al. J Biol Chem, 2012 Mar 16. PMID 22294686, Free PMC Article
  5. MiR-19b-3p regulated by BC002059/ABHD10 axis promotes cell apoptosis in myocardial infarction. Liao B, et al. Biol Direct, 2022 Aug 18. PMID 35978367, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Elk-3 target Abhd10 ameliorates hepatotoxic injury and fibrosis in alcoholic liver disease.
    Title: The Elk-3 target Abhd10 ameliorates hepatotoxic injury and fibrosis in alcoholic liver disease.
  2. MiR-19b-3p regulated by BC002059/ABHD10 axis promotes cell apoptosis in myocardial infarction.
    Title: MiR-19b-3p regulated by BC002059/ABHD10 axis promotes cell apoptosis in myocardial infarction.
  3. mitochondrial localization of rat Abhd10
    Title: ALS-linked mutant superoxide dismutase 1 (SOD1) alters mitochondrial protein composition and decreases protein import.
  4. identification of human ABHD10, which is responsible for AcMPAG deglucuronidation in the liver
    Title: Human α/β hydrolase domain containing 10 (ABHD10) is responsible enzyme for deglucuronidation of mycophenolic acid acyl-glucuronide in liver.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, hydrolyzing O-glycosyl compounds IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity, hydrolyzing O-glycosyl compounds ISO
Inferred from Sequence Orthology
more info
  
enables mycophenolic acid acyl-glucuronide esterase activity IEA
Inferred from Electronic Annotation
more info
  
enables palmitoyl-(protein) hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables palmitoyl-(protein) hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables palmitoyl-(protein) hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in glucuronoside catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein depalmitoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein depalmitoylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein depalmitoylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
palmitoyl-protein thioesterase ABHD10, mitochondrial
Names
abhydrolase domain-containing protein 10, mitochondrial
acyl-protein thioesterase ABHD10
alpha/beta hydrolase domain-containing protein 10, mitochondrial
mycophenolic acid acyl-glucuronide esterase, mitochondrial
NP_001258999.1
NP_001371150.1
NP_001371152.1
NP_766099.3
XP_036015762.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001272070.1 → NP_001258999.1  palmitoyl-protein thioesterase ABHD10, mitochondrial isoform 2 precursor

    See identical proteins and their annotated locations for NP_001258999.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate exon structure in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK084998, BQ175828, BY281009
    UniProtKB/Swiss-Prot
    Q6PE15
    Conserved Domains (2) summary
    COG0596
    Location:56 → 268
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    pfam12695
    Location:68 → 264
    Abhydrolase_5; Alpha/beta hydrolase family

  2. NM_001384221.1 → NP_001371150.1  palmitoyl-protein thioesterase ABHD10, mitochondrial isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC166572
    Conserved Domains (1) summary
    COG0596
    Location:56 → 282
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

  3. NM_001384223.1 → NP_001371152.1  palmitoyl-protein thioesterase ABHD10, mitochondrial isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC166572
    Conserved Domains (1) summary
    COG0596
    Location:56 → 282
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

  4. NM_172511.4 → NP_766099.3  palmitoyl-protein thioesterase ABHD10, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_766099.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC166572, AK052670, BC027656, BQ175828, BY281009
    Consensus CDS
    CCDS28201.1
    UniProtKB/Swiss-Prot
    Q3TMB4, Q6PE15, Q8C3S8, Q8C724, Q8K188
    Related
    ENSMUSP00000065282.7, ENSMUST00000066983.13
    Conserved Domains (2) summary
    pfam12695
    Location:68 → 270
    Abhydrolase_5; Alpha/beta hydrolase family
    pfam12697
    Location:69 → 277
    Abhydrolase_6; Alpha/beta hydrolase family

RNA

  1. NR_073572.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an internal exon and contains an alternate exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC166572, AK052670, BC027656, BQ175828, BY281009, CX237340

  2. NR_169116.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC166572

  3. NR_169117.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC166572

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    45550088..45563355 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159869.1 → XP_036015762.1  palmitoyl-protein thioesterase ABHD10, mitochondrial isoform X1

    Conserved Domains (1) summary
    COG0596
    Location:56 → 171
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PE15.1 GenPept UniProtKB/Swiss-Prot:Q6PE15

Gene LinkOut

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