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Zfp583 zinc finger protein 583 [ Mus musculus (house mouse) ]

Gene ID: 213011, updated on 11-Apr-2024

Summary

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Official Symbol
Zfp583provided by MGI
Official Full Name
zinc finger protein 583provided by MGI
Primary source
MGI:MGI:2682297
See related
Ensembl:ENSMUSG00000030443 AllianceGenome:MGI:2682297
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Znf583
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in bladder; male associated reproductive structure; testis; ureter; and urethra of male. Orthologous to human ZNF583 (zinc finger protein 583). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 1.4), CNS E14 (RPKM 1.1) and 19 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 A1; 7 3.66 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (6313130..6335954, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (6310131..6332955, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_17972 Neighboring gene epididymal protein 13 Neighboring gene STARR-positive B cell enhancer ABC_E11341 Neighboring gene STARR-seq mESC enhancer starr_17975 Neighboring gene STARR-positive B cell enhancer ABC_E4894 Neighboring gene zinc finger protein 667 Neighboring gene predicted gene, 38944 Neighboring gene zinc finger protein 582 Neighboring gene STARR-positive B cell enhancer ABC_E8944 Neighboring gene STARR-positive B cell enhancer ABC_E442 Neighboring gene STARR-seq mESC enhancer starr_17978 Neighboring gene zinc finger protein 78 Neighboring gene predicted gene, 53349

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  2. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
  3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 583

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033249.3 → NP_001028421.1  zinc finger protein 583

    See identical proteins and their annotated locations for NP_001028421.1

    Status: VALIDATED

    Source sequence(s)
    AC148989, AK133380, AV174083
    Consensus CDS
    CCDS39751.1
    UniProtKB/Swiss-Prot
    Q3V080, Q3V3L4
    Related
    ENSMUSP00000104200.2, ENSMUST00000108560.8
    Conserved Domains (3) summary
    smart00349
    Location:6 → 66
    KRAB; krueppel associated box
    COG5048
    Location:200 → 541
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:241 → 261
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    6313130..6335954 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242340.1 → XP_030098200.1  zinc finger protein 583 isoform X7

    UniProtKB/Swiss-Prot
    Q3V080, Q3V3L4
    Conserved Domains (3) summary
    smart00349
    Location:6 → 66
    KRAB; krueppel associated box
    COG5048
    Location:200 → 541
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:241 → 261
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_011250475.3 → XP_011248777.1  zinc finger protein 583 isoform X7

    See identical proteins and their annotated locations for XP_011248777.1

    UniProtKB/Swiss-Prot
    Q3V080, Q3V3L4
    Related
    ENSMUSP00000053935.8, ENSMUST00000062765.14
    Conserved Domains (3) summary
    smart00349
    Location:6 → 66
    KRAB; krueppel associated box
    COG5048
    Location:200 → 541
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:241 → 261
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. XM_030242339.2 → XP_030098199.1  zinc finger protein 583 isoform X5

    Conserved Domains (3) summary
    smart00349
    Location:38 → 98
    KRAB; krueppel associated box
    COG5048
    Location:232 → 573
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:273 → 293
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. XM_011250474.4 → XP_011248776.1  zinc finger protein 583 isoform X6

    See identical proteins and their annotated locations for XP_011248776.1

    Conserved Domains (3) summary
    smart00349
    Location:6 → 67
    KRAB; krueppel associated box
    COG5048
    Location:201 → 542
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:242 → 262
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. XM_011250473.4 → XP_011248775.1  zinc finger protein 583 isoform X6

    See identical proteins and their annotated locations for XP_011248775.1

    Conserved Domains (3) summary
    smart00349
    Location:6 → 67
    KRAB; krueppel associated box
    COG5048
    Location:201 → 542
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:242 → 262
    ZF_C2H2; C2H2 Zn finger [structural motif]

  6. XM_011250469.3 → XP_011248771.1  zinc finger protein 583 isoform X3

    See identical proteins and their annotated locations for XP_011248771.1

    Conserved Domains (3) summary
    smart00349
    Location:38 → 99
    KRAB; krueppel associated box
    COG5048
    Location:233 → 574
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:274 → 294
    ZF_C2H2; C2H2 Zn finger [structural motif]

  7. XM_011250472.3 → XP_011248774.1  zinc finger protein 583 isoform X4

    Conserved Domains (3) summary
    smart00349
    Location:37 → 98
    KRAB; krueppel associated box
    COG5048
    Location:232 → 573
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:273 → 293
    ZF_C2H2; C2H2 Zn finger [structural motif]

  8. XM_011250468.3 → XP_011248770.1  zinc finger protein 583 isoform X3

    See identical proteins and their annotated locations for XP_011248770.1

    Conserved Domains (3) summary
    smart00349
    Location:38 → 99
    KRAB; krueppel associated box
    COG5048
    Location:233 → 574
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:274 → 294
    ZF_C2H2; C2H2 Zn finger [structural motif]

  9. XM_030242338.1 → XP_030098198.1  zinc finger protein 583 isoform X2

    Conserved Domains (3) summary
    smart00349
    Location:45 → 105
    KRAB; krueppel associated box
    COG5048
    Location:239 → 580
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:280 → 300
    ZF_C2H2; C2H2 Zn finger [structural motif]

  10. XM_030242337.1 → XP_030098197.1  zinc finger protein 583 isoform X1

    Conserved Domains (3) summary
    smart00349
    Location:45 → 106
    KRAB; krueppel associated box
    COG5048
    Location:240 → 581
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:281 → 301
    ZF_C2H2; C2H2 Zn finger [structural motif]

  11. XM_011250470.4 → XP_011248772.1  zinc finger protein 583 isoform X3

    See identical proteins and their annotated locations for XP_011248772.1

    Conserved Domains (3) summary
    smart00349
    Location:38 → 99
    KRAB; krueppel associated box
    COG5048
    Location:233 → 574
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:274 → 294
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3V080.1 GenPept UniProtKB/Swiss-Prot:Q3V080

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