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Tnpo2 transportin 2 (importin 3, karyopherin beta 2b) [ Mus musculus (house mouse) ]

Gene ID: 212999, updated on 21-Apr-2024

Summary

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Official Symbol
Tnpo2provided by MGI
Official Full Name
transportin 2 (importin 3, karyopherin beta 2b)provided by MGI
Primary source
MGI:MGI:2384849
See related
Ensembl:ENSMUSG00000031691 AllianceGenome:MGI:2384849
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IPO3; TRN2; Knpb2b; Kpnb2b; 1110034O24Rik
Summary
Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Acts upstream of or within negative regulation of muscle cell differentiation and protein import into nucleus. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including adrenal gland; alimentary system; gallbladder; genitourinary system; and nervous system. Orthologous to human TNPO2 (transportin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 27.2), thymus adult (RPKM 27.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 C3; 8 41.51 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (85763502..85784214)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (85036873..85057585)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_22148 Neighboring gene guided entry of tail-anchored proteins factor 3, ATPase Neighboring gene STARR-positive B cell enhancer ABC_E884 Neighboring gene STARR-positive B cell enhancer ABC_E8254 Neighboring gene telomerase RNA component interacting RNase Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:87560506-87560689 Neighboring gene RIKEN cDNA A230103J11 gene Neighboring gene predicted gene, 25506 Neighboring gene STARR-seq mESC enhancer starr_22150 Neighboring gene F-box and WD-40 domain protein 9 Neighboring gene microRNA 7070 Neighboring gene G protein subunit gamma 14

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Distinct effects of importin α2 and α4 on Oct3/4 localization and expression in mouse embryonic stem cells. Young JC, et al. FASEB J, 2011 Nov. PMID 21840941
  2. Involvement of transportin 2-mediated HuR import in muscle cell differentiation. van der Giessen K, et al. Mol Biol Cell, 2007 Jul. PMID 17475777, Free PMC Article
  3. Regulation of Gli ciliary localization and Hedgehog signaling by the PY-NLS/karyopherin-β2 nuclear import system. Han Y, et al. PLoS Biol, 2017 Aug. PMID 28777795, Free PMC Article
  4. RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly. Lo JC, et al. PLoS Genet, 2012. PMID 23055941, Free PMC Article
  5. Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes. Bulfone A, et al. J Neurosci, 2005 Aug 17. PMID 16107646, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. essential for Hedgehog pathway activation; mediates ciliary translocation of Gli proteins
    Title: Regulation of Gli ciliary localization and Hedgehog signaling by the PY-NLS/karyopherin-β2 nuclear import system.
  2. Early in muscle differentiation, HuR is localized to the nucleus of myoblasts by active Transportin 2 (TRN2)-mediated import.
    Title: Involvement of transportin 2-mediated HuR import in muscle cell differentiation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC6380

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables nuclear import signal receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear localization sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transportin-2
Names
karyopherin (importin) beta 2b
karyopherin beta-2b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122843.2 → NP_001116315.1  transportin-2 isoform 1

    See identical proteins and their annotated locations for NP_001116315.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-3 and 7 all encode the same isoform (1).
    Source sequence(s)
    AC163703
    Consensus CDS
    CCDS22491.1
    UniProtKB/TrEMBL
    E9PV58, Q3U316
    Related
    ENSMUSP00000133076.2, ENSMUST00000166592.2
    Conserved Domains (2) summary
    COG5215
    Location:22 → 756
    KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
    sd00044
    Location:93 → 114
    HEAT; HEAT repeat [structural motif]

  2. NM_001364031.1 → NP_001350960.1  transportin-2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variants 1, 2, and 7, encodes isoform 1.
    Source sequence(s)
    AC163703, AK029774, AK155760, BQ771085, BY149255
    Consensus CDS
    CCDS22491.1
    UniProtKB/TrEMBL
    E9PV58, Q3U316
    Conserved Domains (2) summary
    COG5215
    Location:22 → 756
    KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
    sd00044
    Location:93 → 114
    HEAT; HEAT repeat [structural motif]

  3. NM_001364032.1 → NP_001350961.1  transportin-2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variants 5 and 6, encodes isoform 2.
    Source sequence(s)
    AC163703, AK029774, AK155760, BQ771085, BY149255, BY233571, CB246525
    Consensus CDS
    CCDS90431.1
    UniProtKB/Swiss-Prot
    Q8C0U9, Q99LG2
    UniProtKB/TrEMBL
    Q3U316
    Conserved Domains (2) summary
    COG5215
    Location:22 → 756
    KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
    sd00044
    Location:93 → 114
    HEAT; HEAT repeat [structural motif]

  4. NM_001364033.1 → NP_001350962.1  transportin-2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variants 4 and 6, encodes isoform 2.
    Source sequence(s)
    AC163703, AK029774, AK155760, BQ771085, BY149255, CB246525, CB246965
    Consensus CDS
    CCDS90431.1
    UniProtKB/Swiss-Prot
    Q8C0U9, Q99LG2
    UniProtKB/TrEMBL
    Q3U316
    Conserved Domains (2) summary
    COG5215
    Location:22 → 756
    KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
    sd00044
    Location:93 → 114
    HEAT; HEAT repeat [structural motif]

  5. NM_001364034.1 → NP_001350963.1  transportin-2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variants 4 and 5, encodes isoform 2.
    Source sequence(s)
    AC163703, AK029774, AK155760, BQ771085, BY130364, BY149255, CB246525, CB246965
    Consensus CDS
    CCDS90431.1
    UniProtKB/Swiss-Prot
    Q8C0U9, Q99LG2
    UniProtKB/TrEMBL
    Q3U316
    Related
    ENSMUSP00000147583.2, ENSMUST00000211601.2
    Conserved Domains (2) summary
    COG5215
    Location:22 → 756
    KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
    sd00044
    Location:93 → 114
    HEAT; HEAT repeat [structural motif]

  6. NM_001379096.1 → NP_001366025.1  transportin-2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7), as well as variants 1-3, encodes isoform 1.
    Source sequence(s)
    AC163703
    UniProtKB/TrEMBL
    E9PV58, Q3U316
    Conserved Domains (2) summary
    COG5215
    Location:22 → 756
    KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
    sd00044
    Location:93 → 114
    HEAT; HEAT repeat [structural motif]

  7. NM_145390.5 → NP_663365.3  transportin-2 isoform 1

    See identical proteins and their annotated locations for NP_663365.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) contains the 5'-most exon compared to variant 2. Variants 1-3 and 7 all encode the same isoform (1).
    Source sequence(s)
    AC163703
    Consensus CDS
    CCDS22491.1
    UniProtKB/TrEMBL
    E9PV58, Q3U316
    Related
    ENSMUSP00000091051.5, ENSMUST00000093360.12
    Conserved Domains (2) summary
    COG5215
    Location:22 → 756
    KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
    sd00044
    Location:93 → 114
    HEAT; HEAT repeat [structural motif]

RNA

  1. NR_166484.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC163703

  2. NR_166485.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC163703

  3. NR_166486.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC163703

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    85763502..85784214
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017312649.2 → XP_017168138.1  transportin-2 isoform X3

    UniProtKB/TrEMBL
    Q3U316
    Conserved Domains (3) summary
    COG5215
    Location:103 → 634
    KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
    sd00044
    Location:5 → 33
    HEAT; HEAT repeat [structural motif]
    pfam13646
    Location:52 → 132
    HEAT_2; HEAT repeats

  2. XM_036153866.1 → XP_036009759.1  transportin-2 isoform X2

    UniProtKB/TrEMBL
    Q3U316
    Conserved Domains (3) summary
    COG5215
    Location:103 → 634
    KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
    sd00044
    Location:5 → 33
    HEAT; HEAT repeat [structural motif]
    pfam13646
    Location:52 → 132
    HEAT_2; HEAT repeats

  3. XM_017312650.2 → XP_017168139.1  transportin-2 isoform X3

    UniProtKB/TrEMBL
    Q3U316
    Conserved Domains (3) summary
    COG5215
    Location:103 → 634
    KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
    sd00044
    Location:5 → 33
    HEAT; HEAT repeat [structural motif]
    pfam13646
    Location:52 → 132
    HEAT_2; HEAT repeats

  4. XM_011248342.4 → XP_011246644.1  transportin-2 isoform X1

    See identical proteins and their annotated locations for XP_011246644.1

    UniProtKB/Swiss-Prot
    Q8C0U9, Q99LG2
    UniProtKB/TrEMBL
    Q3U316
    Conserved Domains (2) summary
    COG5215
    Location:22 → 756
    KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
    sd00044
    Location:93 → 114
    HEAT; HEAT repeat [structural motif]

  5. XM_036153865.1 → XP_036009758.1  transportin-2 isoform X1

    UniProtKB/Swiss-Prot
    Q8C0U9, Q99LG2
    UniProtKB/TrEMBL
    Q3U316
    Conserved Domains (2) summary
    COG5215
    Location:22 → 756
    KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
    sd00044
    Location:93 → 114
    HEAT; HEAT repeat [structural motif]

RNA

  1. XR_878792.4 RNA Sequence

    Related
    ENSMUST00000210576.2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99LG2.1 GenPept UniProtKB/Swiss-Prot:Q99LG2

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