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Galnt17 polypeptide N-acetylgalactosaminyltransferase 17 [ Mus musculus (house mouse) ]

Gene ID: 212996, updated on 11-Apr-2024

Summary

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Official Symbol
Galnt17provided by MGI
Official Full Name
polypeptide N-acetylgalactosaminyltransferase 17provided by MGI
Primary source
MGI:MGI:2137594
See related
Ensembl:ENSMUSG00000034040 AllianceGenome:MGI:2137594
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gcap8; Galnt19; Wbscr17; E330012B09Rik
Summary
Predicted to enable carbohydrate binding activity; metal ion binding activity; and polypeptide N-acetylgalactosaminyltransferase activity. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; musculoskeletal system; and sensory organ. Orthologous to human GALNT17 (polypeptide N-acetylgalactosaminyltransferase 17). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 7.1), cortex adult (RPKM 6.3) and 18 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 G2; 5 70.66 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (130903181..131336360, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (130874343..131307522, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A330070K13 gene Neighboring gene STARR-seq mESC enhancer starr_14475 Neighboring gene STARR-seq mESC enhancer starr_14476 Neighboring gene STARR-seq mESC enhancer starr_14477 Neighboring gene STARR-seq mESC enhancer starr_14478 Neighboring gene calneuron 1 Neighboring gene STARR-seq mESC enhancer starr_14479 Neighboring gene predicted gene, 40337 Neighboring gene STARR-seq mESC enhancer starr_14481 Neighboring gene predicted gene, 40338 Neighboring gene STARR-seq mESC enhancer starr_14482 Neighboring gene STARR-seq mESC enhancer starr_14484 Neighboring gene STARR-seq mESC enhancer starr_14488 Neighboring gene predicted gene, 29681 Neighboring gene STARR-seq mESC enhancer starr_14493 Neighboring gene STARR-seq mESC enhancer starr_14494 Neighboring gene autism susceptibility candidate 2 Neighboring gene predicted gene, 54306

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Galnt17 loss-of-function leads to developmental delay and abnormal coordination, activity, and social interactions with cerebellar vermis pathology. Chen CY, et al. Dev Biol, 2022 Oct. PMID 36002036, Free PMC Article
  2. A Mouse Mutation That Dysregulates Neighboring Galnt17 and Auts2 Genes Is Associated with Phenotypes Related to the Human AUTS2 Syndrome. Weisner PA, et al. G3 (Bethesda), 2019 Nov 5. PMID 31554716, Free PMC Article
  3. A putative polypeptide N-acetylgalactosaminyltransferase/Williams-Beuren syndrome chromosome region 17 (WBSCR17) regulates lamellipodium formation and macropinocytosis. Nakayama Y, et al. J Biol Chem, 2012 Sep 14. PMID 22787146, Free PMC Article
  4. Cellular distribution of the RNA transcripts of a newly discovered gene in the brain of normal, weaver, Purkinje cell degeneration and reeler mutant mice as evidenced by in situ hybridization histochemistry. Kambouris M, et al. Brain Res Mol Brain Res, 1993 Jun. PMID 8326827
  5. Molecular characterization of a novel cDNA from murine cerebellum, developmental expression, and distribution in brain. Kambouris M, et al. Brain Res Mol Brain Res, 1994 Sep. PMID 7808217

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Galnt17 loss-of-function leads to developmental delay and abnormal coordination, activity, and social interactions with cerebellar vermis pathology.
    Title: Galnt17 loss-of-function leads to developmental delay and abnormal coordination, activity, and social interactions with cerebellar vermis pathology.
  2. Description of a mouse mutation, T(5G2;8A1)GSO, a reciprocal translocation that breaks between Auts2 and Galnt17 and dysregulates both genes and Is associated with phenotypes related to the human AUTS2 syndrome.
    Title: A Mouse Mutation That Dysregulates Neighboring Galnt17 and Auts2 Genes Is Associated with Phenotypes Related to the Human AUTS2 Syndrome.
  3. a subset of O-glycosylation produced by WBSCR17 controls dynamic membrane trafficking, probably between the cell surface and the late endosomes through macropinocytosis
    Title: A putative polypeptide N-acetylgalactosaminyltransferase/Williams-Beuren syndrome chromosome region 17 (WBSCR17) regulates lamellipodium formation and macropinocytosis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables polypeptide N-acetylgalactosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
polypeptide N-acetylgalactosaminyltransferase 17
Names
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like 3
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase
Williams-Beuren syndrome chromosome region 17 homolog
galNAc-T-like protein 3
granule cell antiserum positive 8
polypeptide GalNAc transferase-like protein 3
polypeptide N-acetylgalactosaminyltransferase-like 3
pp-GaNTase-like protein 3
protein-UDP acetylgalactosaminyltransferase-like protein 3
putative polypeptide N-acetylgalactosaminyltransferase-like protein 3
williams-Beuren syndrome chromosomal region 17 protein homolog
NP_660253.2
XP_006504465.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145218.3 → NP_660253.2  polypeptide N-acetylgalactosaminyltransferase 17 precursor

    See identical proteins and their annotated locations for NP_660253.2

    Status: VALIDATED

    Source sequence(s)
    AC118926, BC069177
    Consensus CDS
    CCDS39296.1
    UniProtKB/Swiss-Prot
    Q7TT15, Q8BKN7, Q8BUY1, Q8BX73, Q8BZC8, Q8K483
    UniProtKB/TrEMBL
    Q59J92
    Related
    ENSMUSP00000083187.6, ENSMUST00000086023.13
    Conserved Domains (2) summary
    cd02510
    Location:155 → 454
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    cd00161
    Location:467 → 593
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    130903181..131336360 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504402.5 → XP_006504465.1  polypeptide N-acetylgalactosaminyltransferase 17 isoform X1

    See identical proteins and their annotated locations for XP_006504465.1

    Conserved Domains (2) summary
    pfam00652
    Location:141 → 267
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
    cl11394
    Location:1 → 130
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TT15.1 GenPept UniProtKB/Swiss-Prot:Q7TT15

Gene LinkOut

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