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Catsper2 cation channel, sperm associated 2 [ Mus musculus (house mouse) ]

Gene ID: 212670, updated on 5-Mar-2024

Summary

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Official Symbol
Catsper2provided by MGI
Official Full Name
cation channel, sperm associated 2provided by MGI
Primary source
MGI:MGI:2387404
See related
Ensembl:ENSMUSG00000033486 AllianceGenome:MGI:2387404
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable calcium activated cation channel activity; calcium channel activity; and voltage-gated ion channel activity. Acts upstream of or within fertilization; flagellated sperm motility; and sperm capacitation. Located in sperm flagellum. Part of CatSper complex. Orthologous to human CATSPER2 (cation channel sperm associated 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 30.8) and CNS E18 (RPKM 1.2) See more
Orthologs
human all
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Genomic context

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Location:
2 E5; 2 60.38 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (121222109..121245082, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (121391633..121414598, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 33947 Neighboring gene creatine kinase, mitochondrial 1, ubiquitous Neighboring gene stereocilin Neighboring gene STARR-positive B cell enhancer ABC_E9202 Neighboring gene protein disulfide isomerase associated 3 Neighboring gene STARR-positive B cell enhancer ABC_E3397 Neighboring gene STARR-positive B cell enhancer ABC_E3398 Neighboring gene elongation factor RNA polymerase II-like 3 Neighboring gene serine incorporator 4 Neighboring gene small EDRK-rich factor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of the promoter region of the murine Catsper2 gene. Contreras-Marciales ADP, et al. FEBS Open Bio, 2022 Dec. PMID 36345591, Free PMC Article
  2. CatSper-null mutant spermatozoa are unable to ascend beyond the oviductal reservoir. Ho K, et al. Reprod Fertil Dev, 2009. PMID 19210926
  3. Identical phenotypes of CatSper1 and CatSper2 null sperm. Carlson AE, et al. J Biol Chem, 2005 Sep 16. PMID 16036917
  4. Intramembranal disulfide cross-linking elucidates the super-quaternary structure of mammalian CatSpers. Bystroff C. Reprod Biol, 2018 Mar. PMID 29371110, Free PMC Article
  5. Hyperactivated sperm motility driven by CatSper2 is required for fertilization. Quill TA, et al. Proc Natl Acad Sci U S A, 2003 Dec 9. PMID 14657366, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Characterization of the promoter region of the murine Catsper2 gene.
    Title: Characterization of the promoter region of the murine Catsper2 gene.
  2. Data suggest that Catsper1, Catsper2, Catsper3, and Catsper4 form protein multimer with hypothetical activities of flippase and disulfide isomerase.
    Title: Intramembranal disulfide cross-linking elucidates the super-quaternary structure of mammalian CatSpers.
  3. CatSper-null mutant spermatozoa are unable to ascend beyond the oviductal reservoir.
    Title: CatSper-null mutant spermatozoa are unable to ascend beyond the oviductal reservoir.
  4. Data show that there is a significant downregulation of CatSpers 2 following spinal cord injury.
    Title: CatSper genes expression, semen characteristics and histology of testes in the contusive spinal cord-injured mice model.
  5. CatSper1 and CatSper2 null sperm show identical phenotypes in mice
    Title: Identical phenotypes of CatSper1 and CatSper2 null sperm.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium-activated cation channel activity IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within calcium ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in fertilization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within fertilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in flagellated sperm motility IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within flagellated sperm motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in sperm capacitation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within sperm capacitation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of CatSper complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of CatSper complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
  
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in sperm flagellum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cation channel sperm-associated protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153075.3 → NP_694715.2  cation channel sperm-associated protein 2

    See identical proteins and their annotated locations for NP_694715.2

    Status: VALIDATED

    Source sequence(s)
    AL845466
    Consensus CDS
    CCDS38216.1
    UniProtKB/Swiss-Prot
    A2ARP9, A2RSK0, Q91ZP5
    UniProtKB/TrEMBL
    A0A0A0MQ85
    Related
    ENSMUSP00000037222.5, ENSMUST00000038073.5
    Conserved Domains (1) summary
    pfam00520
    Location:105 → 350
    Ion_trans; Ion transport protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    121222109..121245082 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499081.5 → XP_006499144.1  cation channel sperm-associated protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006499144.1

    UniProtKB/Swiss-Prot
    A2ARP9, A2RSK0, Q91ZP5
    UniProtKB/TrEMBL
    A0A0A0MQ85
    Conserved Domains (1) summary
    pfam00520
    Location:105 → 350
    Ion_trans; Ion transport protein

  2. XM_030249229.2 → XP_030105089.1  cation channel sperm-associated protein 2 isoform X3

    UniProtKB/Swiss-Prot
    A2ARP9, A2RSK0, Q91ZP5
    Conserved Domains (1) summary
    pfam00520
    Location:105 → 262
    Ion_trans; Ion transport protein

  3. XM_030249227.2 → XP_030105087.1  cation channel sperm-associated protein 2 isoform X3

    UniProtKB/Swiss-Prot
    A2ARP9, A2RSK0, Q91ZP5
    Conserved Domains (1) summary
    pfam00520
    Location:105 → 262
    Ion_trans; Ion transport protein

  4. XM_011239413.4 → XP_011237715.1  cation channel sperm-associated protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011237715.1

    UniProtKB/Swiss-Prot
    A2ARP9, A2RSK0, Q91ZP5
    UniProtKB/TrEMBL
    A0A0A0MQ85
    Conserved Domains (1) summary
    pfam00520
    Location:105 → 350
    Ion_trans; Ion transport protein

  5. XM_030249234.2 → XP_030105094.1  cation channel sperm-associated protein 2 isoform X7

    Conserved Domains (1) summary
    pfam00520
    Location:105 → 341
    Ion_trans; Ion transport protein

  6. XM_030249233.2 → XP_030105093.1  cation channel sperm-associated protein 2 isoform X6

    Conserved Domains (1) summary
    pfam00520
    Location:13 → 112
    Ion_trans; Ion transport protein

  7. XM_006499084.5 → XP_006499147.1  cation channel sperm-associated protein 2 isoform X5

  8. XM_006499082.5 → XP_006499145.1  cation channel sperm-associated protein 2 isoform X2

    UniProtKB/Swiss-Prot
    A2ARP9, A2RSK0, Q91ZP5
    Conserved Domains (1) summary
    pfam00520
    Location:51 → 296
    Ion_trans; Ion transport protein

  9. XM_036160226.1 → XP_036016119.1  cation channel sperm-associated protein 2 isoform X6

    Conserved Domains (1) summary
    pfam00520
    Location:13 → 112
    Ion_trans; Ion transport protein

  10. XM_017316898.3 → XP_017172387.1  cation channel sperm-associated protein 2 isoform X7

    Conserved Domains (1) summary
    pfam00520
    Location:105 → 341
    Ion_trans; Ion transport protein

  11. XM_011239414.4 → XP_011237716.1  cation channel sperm-associated protein 2 isoform X4

    Conserved Domains (1) summary
    pfam00520
    Location:105 → 350
    Ion_trans; Ion transport protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2ARP9.2 GenPept UniProtKB/Swiss-Prot:A2ARP9

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