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Slc66a1 solute carrier family 66 member 1 [ Mus musculus (house mouse) ]

Gene ID: 212555, updated on 21-Apr-2024

Summary

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Official Symbol
Slc66a1provided by MGI
Official Full Name
solute carrier family 66 member 1provided by MGI
Primary source
MGI:MGI:2384837
See related
Ensembl:ENSMUSG00000028744 AllianceGenome:MGI:2384837
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pqlc2
Summary
Predicted to enable L-arginine transmembrane transporter activity and L-lysine transmembrane transporter activity. Predicted to be involved in L-arginine transmembrane transport; amino acid homeostasis; and lysine transport. Predicted to act upstream of or within amino acid transport. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be integral component of organelle membrane. Predicted to be active in lysosomal membrane. Predicted to be integral component of membrane. Is expressed in embryo. Orthologous to human SLC66A1 (solute carrier family 66 member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen adult (RPKM 7.2), kidney adult (RPKM 7.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D3; 4 70.63 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (139021341..139038025, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (139294030..139310760, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene 16287 Neighboring gene STARR-seq mESC enhancer starr_11823 Neighboring gene STARR-seq mESC enhancer starr_11824 Neighboring gene capping actin protein of muscle Z-line subunit beta Neighboring gene STARR-seq mESC enhancer starr_11826 Neighboring gene STARR-positive B cell enhancer ABC_E6244 Neighboring gene aldo-keto reductase family 7, member A5 Neighboring gene STARR-positive B cell enhancer mm9_chr4:138886553-138886854 Neighboring gene cyclin D3, pseudogene Neighboring gene mRNA turnover 4, ribosome maturation factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Lewandowski JP, et al. Dev Biol, 2015 Oct 1. PMID 26238476, Free PMC Article
  2. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (4) 

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC29170, MGC38094

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-arginine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables L-lysine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-lysine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables basic amino acid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in L-arginine transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within amino acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular amino acid homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in lysine transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in organelle membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
lysosomal amino acid transporter 1 homolog
Names
PQ loop repeat containing 2
PQ-loop repeat-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145384.4 → NP_663359.2  lysosomal amino acid transporter 1 homolog

    See identical proteins and their annotated locations for NP_663359.2

    Status: VALIDATED

    Source sequence(s)
    AL807811
    Consensus CDS
    CCDS18843.2
    UniProtKB/Swiss-Prot
    Q8C4N4, Q8R132
    Related
    ENSMUSP00000059772.6, ENSMUST00000053862.12
    Conserved Domains (1) summary
    pfam04193
    Location:37 → 98
    PQ-loop; PQ loop repeat

RNA

  1. NR_151463.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL807811

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    139021341..139038025 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011250219.4 → XP_011248521.1  lysosomal amino acid transporter 1 homolog isoform X1

    UniProtKB/TrEMBL
    A6PWV7, Q8VCS7
    Related
    ENSMUSP00000101427.3, ENSMUST00000105801.9
    Conserved Domains (1) summary
    pfam04193
    Location:37 → 98
    PQ-loop; PQ loop repeat

RNA

  1. XR_003954901.2 RNA Sequence

  2. XR_003954904.2 RNA Sequence

  3. XR_003954903.2 RNA Sequence

  4. XR_003954902.2 RNA Sequence

  5. XR_004941859.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C4N4.1 GenPept UniProtKB/Swiss-Prot:Q8C4N4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
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