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Nepro nucleolus and neural progenitor protein [ Mus musculus (house mouse) ]

Gene ID: 212547, updated on 3-Apr-2024

Summary

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Official Symbol
Neproprovided by MGI
Official Full Name
nucleolus and neural progenitor proteinprovided by MGI
Primary source
MGI:MGI:2384836
See related
Ensembl:ENSMUSG00000036208 AllianceGenome:MGI:2384836
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Acts upstream of or within negative regulation of neuron differentiation and positive regulation of Notch signaling pathway. Located in nucleolus. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; integumental system; and nervous system. Human ortholog(s) of this gene implicated in anauxetic dysplasia 3. Orthologous to human NEPRO (nucleolus and neural progenitor protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 4.9), limb E14.5 (RPKM 4.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 B4; 16 29.04 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (44544645..44559994)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (44724301..44738856)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40908 Neighboring gene predicted gene, 46571 Neighboring gene VISTA enhancer mm1637 Neighboring gene predicted gene, 30311 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:44692039-44692222 Neighboring gene STARR-seq mESC enhancer starr_40911 Neighboring gene STARR-positive B cell enhancer ABC_E10905 Neighboring gene predicted gene, 30445 Neighboring gene STARR-positive B cell enhancer mm9_chr16:44746411-44746712 Neighboring gene GTP-binding protein 8 (putative) Neighboring gene STARR-positive B cell enhancer ABC_E5543 Neighboring gene CD200 receptor 1 Neighboring gene lactate dehydrogenase A pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of Nepro, a gene required for the maintenance of neocortex neural progenitor cells downstream of Notch. Muroyama Y, et al. Development, 2009 Dec. PMID 19906856
  2. Nepro is localized in the nucleolus and essential for preimplantation development in mice. Hashimoto M, et al. Dev Growth Differ, 2015 Sep. PMID 26178919
  3. BCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets. Tiberi L, et al. Nat Neurosci, 2012 Dec. PMID 23160044
  4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Nepro is a nucleolus-associated protein, and its loss leads to the apoptosis before blastocyst formation in mice.
    Title: Nepro is localized in the nucleolus and essential for preimplantation development in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Clone Names

  • MGC27931

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of neuron differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
nucleolus and neural progenitor protein
Names
neural progenitor protein
protein nepro

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001416872.1 → NP_001403801.1  nucleolus and neural progenitor protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC122217, AC124180

  2. NM_001416873.1 → NP_001403802.1  nucleolus and neural progenitor protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC122217, AC124180

  3. NM_001416874.1 → NP_001403803.1  nucleolus and neural progenitor protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC122217, AC124180

  4. NM_145972.5 → NP_666084.1  nucleolus and neural progenitor protein isoform 1

    See identical proteins and their annotated locations for NP_666084.1

    Status: VALIDATED

    Source sequence(s)
    AC122217, AC124180
    Consensus CDS
    CCDS28187.1
    UniProtKB/Swiss-Prot
    Q8R2U2
    UniProtKB/TrEMBL
    Q3TS42
    Related
    ENSMUSP00000038779.8, ENSMUST00000048788.14
    Conserved Domains (1) summary
    pfam14780
    Location:12 → 202
    DUF4477; Domain of unknown function (DUF4477)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    44544645..44559994
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R2U2.1 GenPept UniProtKB/Swiss-Prot:Q8R2U2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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