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Trmt1 tRNA methyltransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 212528, updated on 11-Apr-2024

Summary

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Official Symbol
Trmt1provided by MGI
Official Full Name
tRNA methyltransferase 1provided by MGI
Primary source
MGI:MGI:1289155
See related
Ensembl:ENSMUSG00000001909 AllianceGenome:MGI:1289155
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6720477L24; D8Ertd812e; 6720406L13Rik
Summary
Predicted to enable tRNA (guanine-N2-)-methyltransferase activity. Predicted to be involved in tRNA N2-guanine methylation. Predicted to act upstream of or within methylation and tRNA processing. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human TRMT1 (tRNA methyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 20.0), testis adult (RPKM 19.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 C3; 8 41.02 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (85412953..85426437)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (84686324..84699808)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_22134 Neighboring gene STARR-positive B cell enhancer ABC_E5025 Neighboring gene STARR-positive B cell enhancer ABC_E883 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:87188874-87189057 Neighboring gene predicted gene, 26664 Neighboring gene immediate early response 2 Neighboring gene nucleus accumbens associated 1, BEN and BTB (POZ) domain containing Neighboring gene STARR-positive B cell enhancer ABC_E6667 Neighboring gene STARR-positive B cell enhancer ABC_E5026 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:87228416-87228525 Neighboring gene lymphoblastomic leukemia 1 Neighboring gene nuclear factor I/X Neighboring gene RIKEN cDNA G430095P16 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  2. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  3. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA (guanine(10)-N2)-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA (guanine(26)-N2)-dimethyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA N2-guanine methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within tRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tRNA (guanine(26)-N(2))-dimethyltransferase
Names
TRM1 tRNA methyltransferase 1 homolog
n(2),N(2)-dimethylguanosine tRNA methyltransferase
tRNA 2,2-dimethylguanosine-26 methyltransferase
tRNA(guanine-26,N(2)-N(2)) methyltransferase
tRNA(m(2,2)G26)dimethyltransferase
NP_001158031.1
NP_001158032.1
NP_001351104.1
NP_001351105.1
NP_932137.2
XP_006530874.1
XP_006530875.1
XP_006530876.1
XP_006530878.1
XP_030099261.1
XP_036009755.1
XP_036009756.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164559.1 → NP_001158031.1  tRNA (guanine(26)-N(2))-dimethyltransferase isoform 1

    See identical proteins and their annotated locations for NP_001158031.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice site in the 5' UTR, compared to variant 1. This variant encodes isoform 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK159467, BB055133, CN528783
    Consensus CDS
    CCDS40410.2
    UniProtKB/Swiss-Prot
    Q3TBY4, Q3TX08
    UniProtKB/TrEMBL
    A0A0R4IZW7
    Related
    ENSMUSP00000105389.3, ENSMUST00000109767.9
    Conserved Domains (2) summary
    smart00356
    Location:599 → 625
    ZnF_C3H1; zinc finger
    pfam02005
    Location:65 → 499
    TRM; N2,N2-dimethylguanosine tRNA methyltransferase

  2. NM_001164560.1 → NP_001158032.1  tRNA (guanine(26)-N(2))-dimethyltransferase isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses different splice sites in the first two exons which results in the use of an upstream translation start codon, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct N-terminus when it is compared to isoform 1.
    Source sequence(s)
    AK159467, BB055133, CN528783
    Consensus CDS
    CCDS52619.1
    UniProtKB/TrEMBL
    E9PWD4, Q3TD26
    Related
    ENSMUSP00000105390.3, ENSMUST00000109768.9
    Conserved Domains (2) summary
    smart00356
    Location:592 → 618
    ZnF_C3H1; zinc finger
    pfam02005
    Location:58 → 492
    TRM; N2,N2-dimethylguanosine tRNA methyltransferase

  3. NM_001364175.1 → NP_001351104.1  tRNA (guanine(26)-N(2))-dimethyltransferase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AK078395, AK159467, BB055133, BB579502, BB841866
    Conserved Domains (2) summary
    smart00356
    Location:339 → 365
    ZnF_C3H1; zinc finger
    cl17173
    Location:1 → 239
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  4. NM_001364176.1 → NP_001351105.1  tRNA (guanine(26)-N(2))-dimethyltransferase isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC145556
    UniProtKB/TrEMBL
    Q8R2M8
    Conserved Domains (2) summary
    smart00356
    Location:574 → 600
    ZnF_C3H1; zinc finger
    pfam02005
    Location:40 → 474
    TRM; N2,N2-dimethylguanosine tRNA methyltransferase

  5. NM_198020.2 → NP_932137.2  tRNA (guanine(26)-N(2))-dimethyltransferase isoform 1

    See identical proteins and their annotated locations for NP_932137.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and it encodes the longer protein (isoform 1). Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK159467, BB055133, CN528783
    Consensus CDS
    CCDS40410.2
    UniProtKB/Swiss-Prot
    Q3TBY4, Q3TX08
    UniProtKB/TrEMBL
    A0A0R4IZW7
    Related
    ENSMUSP00000001974.5, ENSMUST00000001974.11
    Conserved Domains (2) summary
    smart00356
    Location:599 → 625
    ZnF_C3H1; zinc finger
    pfam02005
    Location:65 → 499
    TRM; N2,N2-dimethylguanosine tRNA methyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    85412953..85426437
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243401.2 → XP_030099261.1  tRNA (guanine(26)-N(2))-dimethyltransferase isoform X3

    Conserved Domains (2) summary
    smart00356
    Location:339 → 365
    ZnF_C3H1; zinc finger
    cl17173
    Location:1 → 239
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  2. XM_006530811.2 → XP_006530874.1  tRNA (guanine(26)-N(2))-dimethyltransferase isoform X1

    UniProtKB/TrEMBL
    Q8R2M8
    Conserved Domains (2) summary
    smart00356
    Location:574 → 600
    ZnF_C3H1; zinc finger
    pfam02005
    Location:40 → 474
    TRM; N2,N2-dimethylguanosine tRNA methyltransferase

  3. XM_006530812.5 → XP_006530875.1  tRNA (guanine(26)-N(2))-dimethyltransferase isoform X2

    See identical proteins and their annotated locations for XP_006530875.1

    Conserved Domains (2) summary
    smart00356
    Location:408 → 434
    ZnF_C3H1; zinc finger
    cl17173
    Location:1 → 308
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  4. XM_036153862.1 → XP_036009755.1  tRNA (guanine(26)-N(2))-dimethyltransferase isoform X3

    Conserved Domains (2) summary
    smart00356
    Location:339 → 365
    ZnF_C3H1; zinc finger
    cl17173
    Location:1 → 239
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  5. XM_006530813.2 → XP_006530876.1  tRNA (guanine(26)-N(2))-dimethyltransferase isoform X2

    See identical proteins and their annotated locations for XP_006530876.1

    Conserved Domains (2) summary
    smart00356
    Location:408 → 434
    ZnF_C3H1; zinc finger
    cl17173
    Location:1 → 308
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  6. XM_036153863.1 → XP_036009756.1  tRNA (guanine(26)-N(2))-dimethyltransferase isoform X3

    Conserved Domains (2) summary
    smart00356
    Location:339 → 365
    ZnF_C3H1; zinc finger
    cl17173
    Location:1 → 239
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  7. XM_006530815.2 → XP_006530878.1  tRNA (guanine(26)-N(2))-dimethyltransferase isoform X3

    Conserved Domains (2) summary
    smart00356
    Location:339 → 365
    ZnF_C3H1; zinc finger
    cl17173
    Location:1 → 239
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RNA

  1. XR_001778420.3 RNA Sequence

  2. XR_004934791.1 RNA Sequence

  3. XR_004934790.1 RNA Sequence

  4. XR_004934792.1 RNA Sequence

  5. XR_001778423.3 RNA Sequence

  6. XR_004934789.1 RNA Sequence

  7. XR_004934793.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TX08.2 GenPept UniProtKB/Swiss-Prot:Q3TX08

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