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Spice1 spindle and centriole associated protein 1 [ Mus musculus (house mouse) ]

Gene ID: 212514, updated on 5-Mar-2024

Summary

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Official Symbol
Spice1provided by MGI
Official Full Name
spindle and centriole associated protein 1provided by MGI
Primary source
MGI:MGI:1196252
See related
Ensembl:ENSMUSG00000043065 AllianceGenome:MGI:1196252
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ccdc52; D16Ertd480e
Summary
Predicted to be involved in metaphase plate congression; mitotic spindle assembly; and regulation of centriole replication. Predicted to act upstream of or within cell division. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be active in centriole; centrosome; and spindle. Is expressed in adenohypophysis; brain ventricular layer; nasal cavity epithelium; testis; and thymus primordium. Orthologous to human SPICE1 (spindle and centriole associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 6.1), CNS E11.5 (RPKM 5.2) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 B4; 16 28.67 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (44167761..44208857)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (44347399..44388492)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene upstream transcription factor family member 3 Neighboring gene SID1 transmembrane family, member 1 Neighboring gene STARR-seq mESC enhancer starr_40897 Neighboring gene STARR-seq mESC enhancer starr_40898 Neighboring gene STARR-seq mESC enhancer starr_40899 Neighboring gene STARR-seq mESC enhancer starr_40902 Neighboring gene cilia and flagella associated protein 44 Neighboring gene STARR-seq mESC enhancer starr_40903 Neighboring gene STARR-seq mESC enhancer starr_40904 Neighboring gene Boc Hedgehog-responsive enhancer Neighboring gene STARR-seq mESC enhancer starr_40905 Neighboring gene VISTA enhancer mm1504 Neighboring gene BOC cell adhesion associated, oncogene regulated Neighboring gene predicted gene, 30064

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor. Pilot-Storck F, et al. Mol Cell Proteomics, 2010 Jul. PMID 20368287, Free PMC Article
  2. Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders. Li J, et al. Nat Neurosci, 2017 Aug. PMID 28671696, Free PMC Article
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in metaphase chromosome alignment IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in metaphase chromosome alignment ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of centriole replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of centriole replication ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
spindle and centriole-associated protein 1
Names
coiled-coil domain containing 52
coiled-coil domain-containing protein 52

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001416915.1 → NP_001403844.1  spindle and centriole-associated protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125191, AC147045
    UniProtKB/Swiss-Prot
    Q8C804, Q8K3I7

  2. NM_001416916.1 → NP_001403845.1  spindle and centriole-associated protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125191, AC147045
    UniProtKB/Swiss-Prot
    Q8C804, Q8K3I7

  3. NM_001416917.1 → NP_001403846.1  spindle and centriole-associated protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125191, AC147045

  4. NM_144550.5 → NP_653133.3  spindle and centriole-associated protein 1 isoform 1

    See identical proteins and their annotated locations for NP_653133.3

    Status: VALIDATED

    Source sequence(s)
    AC125191, AC147045
    Consensus CDS
    CCDS37345.1
    UniProtKB/Swiss-Prot
    Q8C804, Q8K3I7
    Related
    ENSMUSP00000058832.7, ENSMUST00000050897.7
    Conserved Domains (1) summary
    pfam15678
    Location:35 → 436
    SPICE; Centriole duplication and mitotic chromosome congression

RNA

  1. NR_184401.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC125191, AC147045

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    44167761..44208857
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030249036.2 → XP_030104896.1  spindle and centriole-associated protein 1 isoform X2

    Conserved Domains (1) summary
    pfam15678
    Location:1 → 383
    SPICE; Centriole duplication and mitotic chromosome congression

RNA

  1. XR_004939178.1 RNA Sequence

  2. XR_004939177.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C804.2 GenPept UniProtKB/Swiss-Prot:Q8C804

Gene LinkOut

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