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Mtg1 mitochondrial ribosome-associated GTPase 1 [ Mus musculus (house mouse) ]

Gene ID: 212508, updated on 5-Mar-2024

Summary

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Official Symbol
Mtg1provided by MGI
Official Full Name
mitochondrial ribosome-associated GTPase 1provided by MGI
Primary source
MGI:MGI:2685015
See related
Ensembl:ENSMUSG00000039018 AllianceGenome:MGI:2685015
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm169; Gtpbp7
Summary
Predicted to enable GTPase activity. Predicted to be involved in regulation of mitochondrial translation and regulation of respiratory system process. Predicted to act upstream of or within regulation of translation. Located in mitochondrion. Orthologous to human MTG1 (mitochondrial ribosome associated GTPase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 10.0), kidney adult (RPKM 8.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 F4; 7 85.16 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (139717477..139730699)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (140137564..140150786)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene fucose mutarotase Neighboring gene enoyl Coenzyme A hydratase, short chain, 1, mitochondrial Neighboring gene polyamine oxidase (exo-N4-amino) Neighboring gene STARR-positive B cell enhancer ABC_E1747 Neighboring gene shadow of prion protein Neighboring gene olfactory receptor family 6 subfamily AE member 1 Neighboring gene olfactory receptor family 6 subfamily F member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Novel role of mitochondrial GTPases 1 in pathological cardiac hypertrophy. Xu D, et al. J Mol Cell Cardiol, 2019 Mar. PMID 30707992
  2. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC28365

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mitochondrial translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mitochondrial translation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of respiratory system process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial ribosome ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitochondrial ribosome-associated GTPase 1
Names
GTP binding protein 7 (putative)
GTP-binding protein 7
mitochondrial GTPase 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199301.2 → NP_955005.2  mitochondrial ribosome-associated GTPase 1

    See identical proteins and their annotated locations for NP_955005.2

    Status: VALIDATED

    Source sequence(s)
    AK140018, AK144453, AK144625, BY240360
    Consensus CDS
    CCDS52432.1
    UniProtKB/Swiss-Prot
    Q3UMX2, Q3UN50, Q8R2R6
    Related
    ENSMUSP00000036491.9, ENSMUST00000036977.9
    Conserved Domains (2) summary
    cd01856
    Location:29 → 206
    YlqF; Circularly permuted YlqF GTPase
    TIGR03596
    Location:29 → 319
    GTPase_YlqF; ribosome biogenesis GTP-binding protein YlqF

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    139717477..139730699
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242335.2 → XP_030098195.1  mitochondrial ribosome-associated GTPase 1 isoform X2

    Conserved Domains (1) summary
    cd01856
    Location:1 → 166
    YlqF; Circularly permuted YlqF GTPase

  2. XM_036152879.1 → XP_036008772.1  mitochondrial ribosome-associated GTPase 1 isoform X1

    Conserved Domains (1) summary
    cd01856
    Location:22 → 191
    YlqF; Circularly permuted YlqF GTPase

  3. XM_006536170.1 → XP_006536233.1  mitochondrial ribosome-associated GTPase 1 isoform X2

    Conserved Domains (1) summary
    cd01856
    Location:1 → 166
    YlqF; Circularly permuted YlqF GTPase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R2R6.2 GenPept UniProtKB/Swiss-Prot:Q8R2R6

Gene LinkOut

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