Lactb2 lactamase, beta 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lactb2provided by MGI
Official Full Name: lactamase, beta 2provided by MGI
Primary source: MGI:MGI:2442551
See related: Ensembl:ENSMUSG00000025937 AllianceGenome:MGI:2442551
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cgi-83; E430032H21Rik
Summary: Predicted to enable endoribonuclease activity; single-stranded RNA binding activity; and zinc ion binding activity. Predicted to be involved in RNA phosphodiester bond hydrolysis, endonucleolytic. Located in mitochondrion. Is expressed in brain ventricular layer; liver lobe; lung; renal cortex; and submandibular gland primordium. Orthologous to human LACTB2 (lactamase beta 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in kidney adult (RPKM 64.2), liver adult (RPKM 44.6) and 15 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 1 A3; 1 4.29 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (13695069..13730749, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (13625893..13660583, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Transgenic (1) 1 citation

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

NoName (e-PCR)
- UniSTS:234070

RH98763 (e-PCR)
- UniSTS:91517

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA endonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA endonuclease activity	ISO Inferred from Sequence Orthology more info
enables endonuclease activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclease activity	IEA Inferred from Electronic Annotation more info
enables single-stranded RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables single-stranded RNA binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: endoribonuclease LACTB2

Names: beta-lactamase-like protein 2

NP_001404559.1

EC 3.1.27.-

NP_001404562.1

EC 3.1.27.-

NP_001404563.1

EC 3.1.27.-

NP_001404564.1

EC 3.1.27.-

NP_001404565.1

EC 3.1.27.-

NP_663356.1

EC 3.1.27.-

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001417630.1 → NP_001404559.1 endoribonuclease LACTB2 isoform 2

Status: VALIDATED

Source sequence(s)

AC116708
NM_001417633.1 → NP_001404562.1 endoribonuclease LACTB2 isoform 3

Status: VALIDATED

Source sequence(s)

AC116708
NM_001417634.1 → NP_001404563.1 endoribonuclease LACTB2 isoform 4

Status: VALIDATED

Source sequence(s)

AC116708
NM_001417635.1 → NP_001404564.1 endoribonuclease LACTB2 isoform 5

Status: VALIDATED

Source sequence(s)

AC116708
NM_001417636.1 → NP_001404565.1 endoribonuclease LACTB2 isoform 6

Status: VALIDATED

Source sequence(s)

AC116708
NM_145381.3 → NP_663356.1 endoribonuclease LACTB2 isoform 1

See identical proteins and their annotated locations for NP_663356.1

Status: VALIDATED

Source sequence(s)

AC116708

Consensus CDS

CCDS14823.1

UniProtKB/Swiss-Prot

Q99KR3

Related

ENSMUSP00000027071.6, ENSMUST00000027071.7

Conserved Domains (2) summary

COG0491
Location:23 → 223

GloB; Glyoxylase or a related metal-dependent hydrolase, beta-lactamase superfamily II [General function prediction only]

cd07722
Location:14 → 203

LACTB2-like_MBL-fold; uncharacterized subgroup which includes human lactamase beta 2 and related proteins; MBL-fold metallo hydrolase domain