Lcor ligand dependent nuclear receptor corepressor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lcorprovided by MGI
Official Full Name: ligand dependent nuclear receptor corepressorprovided by MGI
Primary source: MGI:MGI:2443930
See related: Ensembl:ENSMUSG00000025019 AllianceGenome:MGI:2443930
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mlr2; Gm340; mKIAA1795; 3110023F06Rik; A630025C20Rik
Summary: Enables chromatin binding activity. Involved in positive regulation of histone H3-K27 trimethylation. Acts upstream of or within negative regulation of transcription by RNA polymerase II and transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including 1st branchial arch; genitourinary system; long bone epiphysis; nervous system; and sensory organ. Orthologous to human LCOR (ligand dependent nuclear receptor corepressor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in whole brain E14.5 (RPKM 2.8), placenta adult (RPKM 2.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 C3; 19 34.97 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (41471121..41584600)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (41482682..41596161)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Long noncoding RNA H19 mediates LCoR to regulate the balance between osteogenic and adipogenic differentiation of mBMSCs in mice through sponging miR-188.
Title: Long noncoding RNA H19 mediates LCoR to impact the osteogenic and adipogenic differentiation of mBMSCs in mice through sponging miR-188.
LCoR negatively regulates early adipogenesis by repressing C/EBP beta transcriptional activity and add LCoR to the growing list of transcriptional corepressors of adipogenesis.
Title: Ligand-dependent corepressor (LCoR) represses the transcription factor C/EBPβ during early adipocyte differentiation.
miR-199a promotes stem cell properties in mammary stem cells and breast cancer stem cells by directly repressing nuclear receptor corepressor LCOR, which primes interferon responses.
Title: Normal and cancerous mammary stem cells evade interferon-induced constraint through the miR-199a-LCOR axis.
These findings suggest that transactivation activities of Mlr1 and Mlr2 are differentially regulated by splicing variants of NOL4, which are expressed in a tissue-selective manner.
Title: Splicing variants of NOL4 differentially regulate the transcription activity of Mlr1 and Mlr2 in cultured cells.
identification and characterization of Mlr2 a homolog of Mblk-1, a transcription factor from the honeybee brain; expressed in various tissues other than testis
Title: Identification and characterization of Mlr1,2: two mouse homologues of Mblk-1, a transcription factor from the honeybee brain(1).

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (4) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables histone deacetylase binding	ISO Inferred from Sequence Orthology more info
enables histone methyltransferase binding	ISO Inferred from Sequence Orthology more info
enables nuclear estrogen receptor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info
enables transcription corepressor binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin-specific protease binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to estradiol stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in transcription initiation-coupled chromatin remodeling	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ligand-dependent corepressor

Names: Mblk1-related protein-2; mblk1-related protein 2; transcription factor MLR2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001370767.1 → NP_001357696.1 ligand-dependent corepressor isoform 1

Status: VALIDATED

Source sequence(s)

AC112271, AC132303

Consensus CDS

CCDS89392.1

UniProtKB/TrEMBL

A0A571BE94, A0A571BF12

Related

ENSMUSP00000158715.2, ENSMUST00000238398.2

Conserved Domains (3) summary

PTZ00441
Location:726 → 959

PTZ00441; sporozoite surface protein 2 (SSP2); Provisional

pfam05109
Location:558 → 823

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam15090
Location:1247 → 1694

DUF4553; Domain of unknown function (DUF4553)
NM_172154.4 → NP_742166.1 ligand-dependent corepressor isoform 2

See identical proteins and their annotated locations for NP_742166.1

Status: VALIDATED

Source sequence(s)

AC132303

Consensus CDS

CCDS29810.1

UniProtKB/Swiss-Prot

Q3U302, Q5CZW7, Q6ZPI3, Q80VA8, Q8BGT2, Q8C9Q0

UniProtKB/TrEMBL

A0A494B9R4, A4FTY7

Related

ENSMUSP00000126441.2, ENSMUST00000163929.2

Conserved Domains (1) summary

pfam05225
Location:352 → 395

HTH_psq; helix-turn-helix, Psq domain