Zfp748 zinc finger protein 748 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zfp748provided by MGI
Official Full Name: zinc finger protein 748provided by MGI
Primary source: MGI:MGI:1916455
See related: Ensembl:ENSMUSG00000095432 AllianceGenome:MGI:1916455
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: KRAB-O; Zfp208; mszf54; Rslcan20/21
Summary: Enables protein-macromolecule adaptor activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in gonad; liver; and mesonephros. Orthologous to several human genes including ZNF107 (zinc finger protein 107); ZNF208 (zinc finger protein 208); and ZNF43 (zinc finger protein 43). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E11.5 (RPKM 2.3), CNS E18 (RPKM 2.2) and 24 other tissues See more
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Genomic context

Location:: 13 B3; 13 34.54 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (67686758..67701257, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (67538641..67553152, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Reduced Sox9 expression in KRAB-knockdown cells supports a role for KRAB-O and perhaps other KRAB genes in mediating SRY function
Title: Functional analysis of the SRY-KRAB interaction in mouse sex determination.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Markers

Zfp748 (e-PCR), detects polymorphism
- UniSTS:525519

Zfp748 (e-PCR), detects polymorphism
- UniSTS:525520

Clone Names

KIAA4236, MGC60742, mKIAA423, 2610014M12Rik

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein-macromolecule adaptor activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: zinc finger protein 748

Names: KRAB zinc finger protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001035231.4 → NP_001030308.1 zinc finger protein 748 isoform 1

See identical proteins and their annotated locations for NP_001030308.1

Status: VALIDATED

Source sequence(s)

CT573016

Consensus CDS

CCDS59589.1

UniProtKB/TrEMBL

Q7TPL6

Related

ENSMUSP00000137928.2, ENSMUST00000181892.9

Conserved Domains (5) summary

smart00349
Location:5 → 63

KRAB; krueppel associated box

COG5048
Location:442 → 875

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:782 → 802

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam01352
Location:5 → 44

KRAB; KRAB box

pfam13465
Location:461 → 483

zf-H2C2_2; Zinc-finger double domain
NM_001401856.1 → NP_001388785.1 zinc finger protein 748 isoform 2

Status: VALIDATED

Source sequence(s)

CT573016

UniProtKB/TrEMBL

Q8BTB4

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

67686758..67701257 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_183145.2: Suppressed sequence

Description

NM_183145.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.