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Dcaf15 DDB1 and CUL4 associated factor 15 [ Mus musculus (house mouse) ]

Gene ID: 212123, updated on 11-Apr-2024

Summary

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Official Symbol
Dcaf15provided by MGI
Official Full Name
DDB1 and CUL4 associated factor 15provided by MGI
Primary source
MGI:MGI:2684420
See related
Ensembl:ENSMUSG00000037103 AllianceGenome:MGI:2684420
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6720484B16
Summary
Predicted to enable small molecule binding activity. Predicted to be involved in protein polyubiquitination and regulation of natural killer cell activation. Predicted to act upstream of or within immune system process. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Orthologous to human DCAF15 (DDB1 and CUL4 associated factor 15). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 77.9), thymus adult (RPKM 65.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 C2; 8 40.3 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (84823698..84831426, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (84097069..84104797, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E73 Neighboring gene STARR-positive B cell enhancer ABC_E5024 Neighboring gene predicted gene 10643 Neighboring gene regulatory factor X, 1 (influences HLA class II expression) Neighboring gene microRNA 709 Neighboring gene STARR-positive B cell enhancer mm9_chr8:86628640-86628941 Neighboring gene predicted gene, 39210 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:86650788-86650941 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:86651237-86651346 Neighboring gene podocan-like 1 Neighboring gene coiled-coil and C2 domain containing 1A Neighboring gene break repair meiotic recombinase recruitment factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. DCAF13 promotes pluripotency by negatively regulating SUV39H1 stability during early embryonic development. Zhang YL, et al. EMBO J, 2018 Sep 14. PMID 30111536, Free PMC Article
  2. DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity. Wang X, et al. Cell Rep, 2021 Jun 22. PMID 34161765
  3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC66593

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables small molecule binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of natural killer cell activation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Cul4-RING E3 ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Cul4-RING E3 ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DDB1- and CUL4-associated factor 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357322.1 → NP_001344251.1  DDB1- and CUL4-associated factor 15 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC159266, AK032982, BB803815, BY273847
    Consensus CDS
    CCDS90424.1
    UniProtKB/Swiss-Prot
    Q3U305, Q6PFH3, Q8BMB2
    Related
    ENSMUSP00000147690.2, ENSMUST00000210279.2
    Conserved Domains (1) summary
    pfam14939
    Location:51 → 259
    DCAF15_WD40; DDB1-and CUL4-substrate receptor 15, WD repeat

  2. NM_172502.4 → NP_766090.2  DDB1- and CUL4-associated factor 15 isoform 1

    See identical proteins and their annotated locations for NP_766090.2

    Status: VALIDATED

    Source sequence(s)
    AC159266
    Consensus CDS
    CCDS40406.1
    UniProtKB/Swiss-Prot
    Q6PFH3
    Related
    ENSMUSP00000038568.8, ENSMUST00000041367.9
    Conserved Domains (1) summary
    pfam14939
    Location:51 → 259
    DCAF15_WD40; DDB1-and CUL4-substrate receptor 15, WD repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    84823698..84831426 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243400.1 → XP_030099260.1  DDB1- and CUL4-associated factor 15 isoform X1

    Conserved Domains (1) summary
    pfam14939
    Location:51 → 259
    DCAF15_WD40; DDB1-and CUL4-substrate receptor 15, WD repeat

  2. XM_011248336.1 → XP_011246638.1  DDB1- and CUL4-associated factor 15 isoform X2

    Conserved Domains (2) summary
    cd20913
    Location:223 → 473
    DCAF15-CTD; C-terminal domain of DDB1- and CUL4-associated factor 15
    cl20823
    Location:9 → 95
    DCAF15-NTD; N-terminal domain of DDB1- and CUL4-associated factor 15

  3. XM_036153861.1 → XP_036009754.1  DDB1- and CUL4-associated factor 15 isoform X2

    Conserved Domains (2) summary
    cd20913
    Location:223 → 473
    DCAF15-CTD; C-terminal domain of DDB1- and CUL4-associated factor 15
    cl20823
    Location:9 → 95
    DCAF15-NTD; N-terminal domain of DDB1- and CUL4-associated factor 15
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PFH3.1 GenPept UniProtKB/Swiss-Prot:Q6PFH3

Gene LinkOut

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