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Nhlrc3 NHL repeat containing 3 [ Mus musculus (house mouse) ]

Gene ID: 212114, updated on 5-Mar-2024

Summary

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Official Symbol
Nhlrc3provided by MGI
Official Full Name
NHL repeat containing 3provided by MGI
Primary source
MGI:MGI:2444520
See related
Ensembl:ENSMUSG00000042997 AllianceGenome:MGI:2444520
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA4083; 4833441N19; 8030451K01Rik
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein polyubiquitination. Is expressed in embryo. Orthologous to human NHLRC3 (NHL repeat containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 7.8), colon adult (RPKM 5.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 C; 3 25.15 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (53359417..53370679, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (53451996..53463258, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40048 Neighboring gene predicted gene 43471 Neighboring gene STARR-seq mESC enhancer starr_07655 Neighboring gene STARR-seq mESC enhancer starr_07656 Neighboring gene predicted gene 16206 Neighboring gene STARR-seq mESC enhancer starr_07657 Neighboring gene proline and serine rich 1 Neighboring gene stomatin (Epb7.2)-like 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Breakdown of the reciprocal stabilization of QBRICK/Frem1, Fras1, and Frem2 at the basement membrane provokes Fraser syndrome-like defects. Kiyozumi D, et al. Proc Natl Acad Sci U S A, 2006 Aug 8. PMID 16880404, Free PMC Article
  2. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  3. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Clone Names

  • KIAA4083, MGC107225, MGC130333

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables translation repressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
NHL repeat-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172501.2 → NP_766089.1  NHL repeat-containing protein 3 precursor

    See identical proteins and their annotated locations for NP_766089.1

    Status: PROVISIONAL

    Source sequence(s)
    AK033167
    Consensus CDS
    CCDS17345.1
    UniProtKB/Swiss-Prot
    Q8CCH2, Q8CDW5
    Related
    ENSMUSP00000055295.8, ENSMUST00000056749.14
    Conserved Domains (3) summary
    COG3391
    Location:66 → 308
    YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]
    cd05819
    Location:107 → 153
    NHL; NHL repeat [structural motif]
    cl18310
    Location:66 → 336
    NHL; NHL repeat unit of beta-propeller proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    53359417..53370679 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CCH2.1 GenPept UniProtKB/Swiss-Prot:Q8CCH2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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