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Zfyve26 zinc finger, FYVE domain containing 26 [ Mus musculus (house mouse) ]

Gene ID: 211978, updated on 5-Mar-2024

Summary

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Official Symbol
Zfyve26provided by MGI
Official Full Name
zinc finger, FYVE domain containing 26provided by MGI
Primary source
MGI:MGI:1924767
See related
Ensembl:ENSMUSG00000066440 AllianceGenome:MGI:1924767
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm893; mKIAA0321; 4930465A13; 9330197E15Rik; A630028O16Rik
Summary
Predicted to enable phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in double-strand break repair via homologous recombination and regulation of cytokinesis. Predicted to act upstream of or within DNA repair and cell division. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be active in centrosome and midbody. Is expressed in central nervous system; retina inner nuclear layer; and retina outer nuclear layer. Used to study hereditary spastic paraplegia 15. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 15. Orthologous to human ZFYVE26 (zinc finger FYVE-type containing 26). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 5.9), placenta adult (RPKM 5.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Zfyve26 in Genome Data Viewer
Location:
12 C3; 12 35.51 cM
Exon count:
42
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (79279120..79343102, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (79232346..79296323, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11514 Neighboring gene retinol dehydrogenase 11 Neighboring gene STARR-seq mESC enhancer starr_32594 Neighboring gene retinol dehydrogenase 12 Neighboring gene STARR-positive B cell enhancer ABC_E920 Neighboring gene STARR-positive B cell enhancer ABC_E4030 Neighboring gene STARR-positive B cell enhancer ABC_E10762 Neighboring gene RAD51 paralog B Neighboring gene STARR-positive B cell enhancer ABC_E3058 Neighboring gene STARR-seq mESC enhancer starr_32597 Neighboring gene STARR-seq mESC enhancer starr_32598 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:80612777-80612978 Neighboring gene STARR-positive B cell enhancer ABC_E3059 Neighboring gene STARR-seq mESC enhancer starr_32600 Neighboring gene STARR-positive B cell enhancer ABC_E5335 Neighboring gene STARR-positive B cell enhancer ABC_E1155 Neighboring gene STARR-positive B cell enhancer ABC_E5336 Neighboring gene STARR-seq mESC enhancer starr_32602 Neighboring gene STARR-seq mESC enhancer starr_32603 Neighboring gene STARR-seq mESC enhancer starr_32604 Neighboring gene STARR-seq mESC enhancer starr_32605 Neighboring gene STARR-seq mESC enhancer starr_32606 Neighboring gene VISTA enhancer mm1393 Neighboring gene STARR-seq mESC enhancer starr_32607 Neighboring gene predicted gene, 36048 Neighboring gene predicted gene 3596

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A hereditary spastic paraplegia mouse model supports a role of ZFYVE26/SPASTIZIN for the endolysosomal system. Khundadze M, et al. PLoS Genet, 2013. PMID 24367272, Free PMC Article
  2. Mouse models for hereditary spastic paraplegia uncover a role of PI4K2A in autophagic lysosome reformation. Khundadze M, et al. Autophagy, 2021 Nov. PMID 33618608, Free PMC Article
  3. Spastic paraplegia proteins spastizin and spatacsin mediate autophagic lysosome reformation. Chang J, et al. J Clin Invest, 2014 Dec. PMID 25365221, Free PMC Article
  4. Novel gene function revealed by mouse mutagenesis screens for models of age-related disease. Potter PK, et al. Nat Commun, 2016 Aug 18. PMID 27534441, Free PMC Article
  5. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Increased levels of lysosomal enzymes in brains of aged knockout mice further support an alteration of the lysosomal compartment upon disruption of Zfyve26
    Title: A hereditary spastic paraplegia mouse model supports a role of ZFYVE26/SPASTIZIN for the endolysosomal system.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0321

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3-phosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within autophagosome organization ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lysosome organization ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in mitotic cytokinesis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in late endosome ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in midbody IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in midbody ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger FYVE domain-containing protein 26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008550.1 → NP_001008550.1  zinc finger FYVE domain-containing protein 26

    See identical proteins and their annotated locations for NP_001008550.1

    Status: VALIDATED

    Source sequence(s)
    AK220333, BY325388
    Consensus CDS
    CCDS36481.1
    UniProtKB/Swiss-Prot
    B9EJ71, Q3TEM9, Q3V1N3, Q5DU37, Q8BY74, Q8CDR8, Q923B4
    Related
    ENSMUSP00000021547.7, ENSMUST00000021547.8
    Conserved Domains (1) summary
    cd15724
    Location:1799 → 1859
    FYVE_ZFY26; FYVE domain found in FYVE domain-containing protein 26 (ZFY26 or ZFYVE26)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    79279120..79343102 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017315012.3 → XP_017170501.1  zinc finger FYVE domain-containing protein 26 isoform X2

    Conserved Domains (1) summary
    cd15724
    Location:1799 → 1859
    FYVE_ZFY26; FYVE domain found in FYVE domain-containing protein 26 (ZFY26 or ZFYVE26)

  2. XM_006515647.4 → XP_006515710.1  zinc finger FYVE domain-containing protein 26 isoform X3

    Conserved Domains (1) summary
    cd15724
    Location:1800 → 1860
    FYVE_ZFY26; FYVE domain found in FYVE domain-containing protein 26 (ZFY26 or ZFYVE26)

  3. XM_017315011.3 → XP_017170500.1  zinc finger FYVE domain-containing protein 26 isoform X1

    Conserved Domains (1) summary
    cd15724
    Location:1800 → 1860
    FYVE_ZFY26; FYVE domain found in FYVE domain-containing protein 26 (ZFY26 or ZFYVE26)

  4. XM_017315014.1 → XP_017170503.1  zinc finger FYVE domain-containing protein 26 isoform X5

    Conserved Domains (1) summary
    cd15724
    Location:981 → 1041
    FYVE_ZFY26; FYVE domain found in FYVE domain-containing protein 26 (ZFY26 or ZFYVE26)

  5. XM_017315013.1 → XP_017170502.1  zinc finger FYVE domain-containing protein 26 isoform X4

    Conserved Domains (1) summary
    cd15724
    Location:982 → 1042
    FYVE_ZFY26; FYVE domain found in FYVE domain-containing protein 26 (ZFY26 or ZFYVE26)

RNA

  1. XR_004937482.1 RNA Sequence

  2. XR_381513.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5DU37.2 GenPept UniProtKB/Swiss-Prot:Q5DU37

Gene LinkOut

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