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Mrgprd MAS-related GPR, member D [ Mus musculus (house mouse) ]

Gene ID: 211578, updated on 30-Apr-2024

Summary

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Official Symbol
Mrgprdprovided by MGI
Official Full Name
MAS-related GPR, member Dprovided by MGI
Primary source
MGI:MGI:3033142
See related
Ensembl:ENSMUSG00000051207 AllianceGenome:MGI:3033142
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mgrd; MrgD; TGR7; Gm499
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within signal transduction. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Is expressed in brain; genitourinary system; skin; and ventral grey horn. Used to study dilated cardiomyopathy. Orthologous to human MRGPRD (MAS related GPR family member D). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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Location:
7 F5; 7 89.06 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (144868572..144877796)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (145314835..145324059)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene two pore segment channel 2 Neighboring gene VISTA enhancer mm1497 Neighboring gene small integral membrane protein 38 Neighboring gene STARR-seq mESC enhancer starr_20570 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:152429156-152429339 Neighboring gene STARR-positive B cell enhancer ABC_E3765 Neighboring gene STARR-seq mESC enhancer starr_20571 Neighboring gene MAS-related GPR, member F Neighboring gene STARR-seq mESC enhancer starr_20573

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Brown adipose tissue transcriptome unveils an important role of the Beta-alanine/alamandine receptor, MrgD, in metabolism. Cerri GC, et al. J Nutr Biochem, 2023 Apr. PMID 36641071
  2. Identification of MrgprD expression in mouse enteric neurons. Xu M, et al. Cell Tissue Res, 2022 May. PMID 35258714
  3. Mas-related G protein-coupled receptor D participates in inflammatory pain by promoting NF-κB activation through interaction with TAK1 and IKK complex. Lan L, et al. Cell Signal, 2020 Dec. PMID 33080316
  4. Expression and Function of Mas-Related G Protein-Coupled Receptor D and Its Ligand Alamandine in Retina. Zhu P, et al. Mol Neurobiol, 2020 Jan. PMID 31392515
  5. Expression and localization of MrgprD in mouse intestinal tract. Zhou C, et al. Cell Tissue Res, 2019 Aug. PMID 30919047, Free PMC Article

See all (73) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Brown adipose tissue transcriptome unveils an important role of the Beta-alanine/alamandine receptor, MrgD, in metabolism.
    Title: Brown adipose tissue transcriptome unveils an important role of the Beta-alanine/alamandine receptor, MrgD, in metabolism.
  2. Impact of genetic deletion of MrgD or Mas receptors in depressive-like behaviour in mice.
    Title: Impact of genetic deletion of MrgD or Mas receptors in depressive-like behaviour in mice.
  3. Identification of MrgprD expression in mouse enteric neurons.
    Title: Identification of MrgprD expression in mouse enteric neurons.
  4. Mas-related G protein-coupled receptor D participates in inflammatory pain by promoting NF-kappaB activation through interaction with TAK1 and IKK complex.
    Title: Mas-related G protein-coupled receptor D participates in inflammatory pain by promoting NF-κB activation through interaction with TAK1 and IKK complex.
  5. Expression and Function of Mas-Related G Protein-Coupled Receptor D and Its Ligand Alamandine in Retina.
    Title: Expression and Function of Mas-Related G Protein-Coupled Receptor D and Its Ligand Alamandine in Retina.
  6. This study shows, for the first time, the expression and localization of MrgprD in the intestinal tract and in macrophages and T lymphocytes, indicating the potential roles of MrgprD in intestinal mobility and immunity.
    Title: Expression and localization of MrgprD in mouse intestinal tract.
  7. MrgD-deficient mice presented a pronounced dilated cardiomyopathy with a marked decrease in systolic function.
    Title: Genetic deletion of the alamandine receptor MRGD leads to dilated cardiomyopathy in mice.
  8. MrgprD is essential in cold allodynia in CCI-induced neuropathic pain through the PKA-TRP-A1 pathway
    Title: Facilitation of MrgprD by TRP-A1 promotes neuropathic pain.
  9. showed that both MRGPRA3+ and MRGPRD+ neurons from hapten-challenged mice displayed a significantly more depolarized resting membrane potential, decreased rheobase, and greater number of action potentials at twice rheobase compared with neurons
    Title: Enhanced excitability of MRGPRA3- and MRGPRD-positive nociceptors in a model of inflammatory itch and pain.
  10. An itching response is mediated in mice by Mrgprd expressed in primary sensory neurons.
    Title: Mechanisms of itch evoked by β-alanine.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (9)  1 citation

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
mas-related G-protein coupled receptor member D
Names
G protein-coupled receptor MrgD
G-protein coupled receptor TGR7
Mas-related G protein-coupled receptor d
beta-alanine receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_203490.4 → NP_987075.1  mas-related G-protein coupled receptor member D

    See identical proteins and their annotated locations for NP_987075.1

    Status: VALIDATED

    Source sequence(s)
    AC132081, AC225443
    Consensus CDS
    CCDS22057.1
    UniProtKB/Swiss-Prot
    Q91ZB8
    UniProtKB/TrEMBL
    Q5UCB4
    Related
    ENSMUSP00000063021.7, ENSMUST00000062163.8
    Conserved Domains (2) summary
    pfam00001
    Location:43 → 278
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:36 → 220
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    144868572..144877796
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91ZB8.1 GenPept UniProtKB/Swiss-Prot:Q91ZB8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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