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Mrgprf MAS-related GPR, member F [ Mus musculus (house mouse) ]

Gene ID: 211577, updated on 11-Apr-2024

Summary

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Official Symbol
Mrgprfprovided by MGI
Official Full Name
MAS-related GPR, member Fprovided by MGI
Primary source
MGI:MGI:2384823
See related
Ensembl:ENSMUSG00000031070 AllianceGenome:MGI:2384823
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mgrc; MrgF
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within signal transduction. Predicted to be located in nuclear membrane and plasma membrane. Orthologous to human MRGPRF (MAS related GPR family member F). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in stomach adult (RPKM 33.6), colon adult (RPKM 25.5) and 15 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 F5; 7 89.05 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (144854646..144863294)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (145300909..145309557)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_20566 Neighboring gene predicted gene 45181 Neighboring gene two pore segment channel 2 Neighboring gene STARR-seq mESC enhancer starr_20567 Neighboring gene VISTA enhancer mm1497 Neighboring gene small integral membrane protein 38 Neighboring gene STARR-seq mESC enhancer starr_20570 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:152429156-152429339 Neighboring gene STARR-positive B cell enhancer ABC_E3765 Neighboring gene STARR-seq mESC enhancer starr_20571 Neighboring gene STARR-seq mESC enhancer starr_20573 Neighboring gene MAS-related GPR, member D

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The ORF49 protein of murine gammaherpesvirus 68 cooperates with RTA in regulating virus replication. Lee S, et al. J Virol, 2007 Sep. PMID 17634244, Free PMC Article
  2. The effect of inflammation on the expression and distribution of the MAS-related gene receptors MrgE and MrgF in the murine ileum. Avula LR, et al. Histochem Cell Biol, 2011 Nov. PMID 21912971
  3. Single-cell profiling reveals heterogeneity and functional patterning of GPCR expression in the vascular system. Kaur H, et al. Nat Commun, 2017 Jun 16. PMID 28621310, Free PMC Article
  4. Orphan G protein-coupled receptors MrgA1 and MrgC11 are distinctively activated by RF-amide-related peptides through the Galpha q/11 pathway. Han SK, et al. Proc Natl Acad Sci U S A, 2002 Nov 12. PMID 12397184, Free PMC Article
  5. A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. Dong X, et al. Cell, 2001 Sep 7. PMID 11551509

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The number of enteric neurons expressing MrgE and MrgF receptors was significantly reduced during intestinal schistosomiasis and ileitis.
    Title: The effect of inflammation on the expression and distribution of the MAS-related gene receptors MrgE and MrgF in the murine ileum.
  2. ORF49 protein promoted the ability of RTA to activate downstream target promoters and enhanced murine gammaherpesvirus 68 replication
    Title: The ORF49 protein of murine gammaherpesvirus 68 cooperates with RTA in regulating virus replication.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC18825

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mas-related G-protein coupled receptor member F
Names
G protein-coupled receptor RTA
Mas-related G protein-coupled receptor c
mas-related gene F protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145379.2 → NP_663354.1  mas-related G-protein coupled receptor member F

    See identical proteins and their annotated locations for NP_663354.1

    Status: PROVISIONAL

    Source sequence(s)
    AC132081
    Consensus CDS
    CCDS22056.1
    UniProtKB/Swiss-Prot
    Q8VCJ6, Q91ZB6
    Related
    ENSMUSP00000033386.6, ENSMUST00000033386.12
    Conserved Domains (1) summary
    pfam00001
    Location:62 → 291
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    144854646..144863294
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508537.5 → XP_006508600.1  mas-related G-protein coupled receptor member F isoform X1

    See identical proteins and their annotated locations for XP_006508600.1

    UniProtKB/TrEMBL
    Q3TZA7
    Conserved Domains (1) summary
    cd15109
    Location:29 → 302
    7tmA_MrgprF; mas-related G protein-coupled receptor subtype F, member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VCJ6.1 GenPept UniProtKB/Swiss-Prot:Q8VCJ6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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