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Ap1ar adaptor-related protein complex 1 associated regulatory protein [ Mus musculus (house mouse) ]

Gene ID: 211556, updated on 5-Mar-2024

Summary

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Official Symbol
Ap1arprovided by MGI
Official Full Name
adaptor-related protein complex 1 associated regulatory proteinprovided by MGI
Primary source
MGI:MGI:2384822
See related
Ensembl:ENSMUSG00000074238 AllianceGenome:MGI:2384822
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gadkin
Summary
Predicted to enable AP-1 adaptor complex binding activity; Arp2/3 complex binding activity; and kinesin binding activity. Acts upstream of or within several processes, including negative regulation of cell motility; negative regulation of substrate adhesion-dependent cell spreading; and regulation of Arp2/3 complex-mediated actin nucleation. Located in endosome. Is expressed in several structures, including cardiovascular system; genitourinary system; gut; integumental system; and nervous system. Orthologous to human AP1AR (adaptor related protein complex 1 associated regulatory protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum adult (RPKM 18.9), colon adult (RPKM 18.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 G2; 3 56.54 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (127600656..127631148, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (127807007..127837523, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene alpha-kinase 1 Neighboring gene STARR-seq mESC enhancer starr_08957 Neighboring gene VISTA enhancer mm1549 Neighboring gene ribosomal protein L19 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E335 Neighboring gene STARR-positive B cell enhancer ABC_E6120 Neighboring gene STARR-positive B cell enhancer ABC_E6121 Neighboring gene TRAF-interacting protein with forkhead-associated domain Neighboring gene STARR-positive B cell enhancer ABC_E6122 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:127540571-127540758 Neighboring gene predicted gene 43653 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:127571005-127571206 Neighboring gene predicted gene, 35585 Neighboring gene family with sequence similarity 241, member A Neighboring gene STARR-positive B cell enhancer ABC_E11217

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Loss of Gadkin Affects Dendritic Cell Migration In Vitro. Schachtner H, et al. PLoS One, 2015. PMID 26624014, Free PMC Article
  2. Contributions of epsinR and gadkin to clathrin-mediated intracellular trafficking. Hirst J, et al. Mol Biol Cell, 2015 Sep 1. PMID 26179914, Free PMC Article
  3. An Integrative Framework Reveals Signaling-to-Transcription Events in Toll-like Receptor Signaling. Mertins P, et al. Cell Rep, 2017 Jun 27. PMID 28658630, Free PMC Article
  4. Gadkin negatively regulates cell spreading and motility via sequestration of the actin-nucleating ARP2/3 complex. Maritzen T, et al. Proc Natl Acad Sci U S A, 2012 Jun 26. PMID 22689987, Free PMC Article
  5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Clone Names

  • MGC7434

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables AP-1 adaptor complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables AP-1 adaptor complex binding ISO
Inferred from Sequence Orthology
more info
  
enables Arp2/3 complex binding ISO
Inferred from Sequence Orthology
more info
  
enables kinesin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinesin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of cell motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of receptor recycling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of substrate adhesion-dependent cell spreading IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of Arp2/3 complex-mediated actin nucleation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of Arp2/3 complex-mediated actin nucleation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of substrate adhesion-dependent cell spreading IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle targeting, trans-Golgi to endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle targeting, trans-Golgi to endosome ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in transport vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
AP-1 complex-associated regulatory protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001346718.3 → NP_001333647.1  AP-1 complex-associated regulatory protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC163391
    Consensus CDS
    CCDS84673.1
    UniProtKB/TrEMBL
    A0A0G2JG85
    Related
    ENSMUSP00000143466.2, ENSMUST00000200409.5

  2. NM_001411484.1 → NP_001398413.1  AP-1 complex-associated regulatory protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC163391

  3. NM_001411486.1 → NP_001398415.1  AP-1 complex-associated regulatory protein isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC163391

  4. NM_001411487.1 → NP_001398416.1  AP-1 complex-associated regulatory protein isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC163391

  5. NM_001411488.1 → NP_001398417.1  AP-1 complex-associated regulatory protein isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC163391

  6. NM_001411489.1 → NP_001398418.1  AP-1 complex-associated regulatory protein isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC163391

  7. NM_001411490.1 → NP_001398419.1  AP-1 complex-associated regulatory protein isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC163391

  8. NM_145964.4 → NP_666076.2  AP-1 complex-associated regulatory protein isoform 1

    See identical proteins and their annotated locations for NP_666076.2

    Status: VALIDATED

    Source sequence(s)
    AC163391
    Consensus CDS
    CCDS38629.1
    UniProtKB/TrEMBL
    E9PYF7
    Related
    ENSMUSP00000059669.7, ENSMUST00000051737.8
    Conserved Domains (1) summary
    pfam15745
    Location:24 → 298
    AP1AR; AP-1 complex-associated regulatory protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    127600656..127631148 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501241.4 → XP_006501304.1  AP-1 complex-associated regulatory protein isoform X2

    Conserved Domains (1) summary
    pfam15745
    Location:74 → 345
    AP1AR; AP-1 complex-associated regulatory protein

  2. XM_006501242.3 → XP_006501305.1  AP-1 complex-associated regulatory protein isoform X3

    Conserved Domains (1) summary
    pfam15745
    Location:99 → 337
    AP1AR; AP-1 complex-associated regulatory protein

  3. XM_006501240.3 → XP_006501303.1  AP-1 complex-associated regulatory protein isoform X1

    Conserved Domains (1) summary
    pfam15745
    Location:99 → 370
    AP1AR; AP-1 complex-associated regulatory protein

  4. XM_006501245.3 → XP_006501308.1  AP-1 complex-associated regulatory protein isoform X6

    Conserved Domains (1) summary
    pfam15745
    Location:18 → 289
    AP1AR; AP-1 complex-associated regulatory protein

  5. XM_006501243.3 → XP_006501306.1  AP-1 complex-associated regulatory protein isoform X4

    Conserved Domains (1) summary
    pfam15745
    Location:53 → 324
    AP1AR; AP-1 complex-associated regulatory protein
Nucleotide Protein Strain
Heading Accession and Version

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