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Odad1 outer dynein arm docking complex subunit 1 [ Mus musculus (house mouse) ]

Gene ID: 211535, updated on 21-Apr-2024

Summary

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Official Symbol
Odad1provided by MGI
Official Full Name
outer dynein arm docking complex subunit 1provided by MGI
Primary source
MGI:MGI:2446120
See related
Ensembl:ENSMUSG00000040189 AllianceGenome:MGI:2446120
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ccdc114
Summary
Predicted to be involved in cilium movement and outer dynein arm assembly. Predicted to be located in cilium. Predicted to be part of outer dynein arm. Predicted to be active in axoneme. Is expressed in brain; olfactory epithelium; parathyroid gland; reproductive system; and ventral grey horn. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 20. Orthologous to human ODAD1 (outer dynein arm docking complex subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 7.8), adrenal adult (RPKM 6.5) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 B3; 7 29.6 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (45572591..45598387)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45923159..45948963)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 143 Neighboring gene STARR-positive B cell enhancer ABC_E8172 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:53178126-53178235 Neighboring gene STARR-positive B cell enhancer ABC_E6547 Neighboring gene STARR-positive B cell enhancer ABC_E873 Neighboring gene epithelial membrane protein 3 Neighboring gene ATP synthase, H+ transporting, mitochondrial F0 complex, subunit g pseudogene Neighboring gene STARR-seq mESC enhancer starr_18859 Neighboring gene predicted gene, 45983 Neighboring gene ATP-binding cassette, sub-family C member 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article
  2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cilium movement IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cilium movement ISO
Inferred from Sequence Orthology
more info
  
involved_in outer dynein arm assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in outer dynein arm assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in axoneme IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in axoneme ISO
Inferred from Sequence Orthology
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cilium ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
part_of outer dynein arm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
outer dynein arm-docking complex subunit 1
Names
coiled-coil domain containing 114
coiled-coil domain-containing protein 114

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364168.1 → NP_001351097.1  outer dynein arm-docking complex subunit 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC149053, AK042062, AK135860, BC100373
    UniProtKB/TrEMBL
    A0A1B0GR16
    Related
    ENSMUSP00000147338.3, ENSMUST00000210039.3
    Conserved Domains (1) summary
    TIGR02169
    Location:24 → 314
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  2. NM_001364169.2 → NP_001351098.1  outer dynein arm-docking complex subunit 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC149053
    UniProtKB/TrEMBL
    A0A1B0GSN0
    Related
    ENSMUSP00000148002.2, ENSMUST00000211367.2

  3. NM_001374632.1 → NP_001361561.1  outer dynein arm-docking complex subunit 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC149053
    UniProtKB/TrEMBL
    A0A1B0GR16
    Related
    ENSMUSP00000042772.5, ENSMUST00000038720.8
    Conserved Domains (1) summary
    TIGR02169
    Location:24 → 314
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

RNA

  1. NR_175373.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC149053

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    45572591..45598387
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540767.5 → XP_006540830.1  outer dynein arm-docking complex subunit 1 isoform X1

    See identical proteins and their annotated locations for XP_006540830.1

    UniProtKB/TrEMBL
    A0A1B0GR16
    Conserved Domains (2) summary
    TIGR02168
    Location:30 → 317
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:472 → 564
    CCDC158; Coiled-coil domain-containing protein 158

  2. XM_006540765.5 → XP_006540828.1  outer dynein arm-docking complex subunit 1 isoform X1

    See identical proteins and their annotated locations for XP_006540828.1

    UniProtKB/TrEMBL
    A0A1B0GR16
    Conserved Domains (2) summary
    TIGR02168
    Location:30 → 317
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:472 → 564
    CCDC158; Coiled-coil domain-containing protein 158

  3. XM_006540772.5 → XP_006540835.1  outer dynein arm-docking complex subunit 1 isoform X5

    Conserved Domains (2) summary
    TIGR02168
    Location:30 → 317
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:472 → 564
    CCDC158; Coiled-coil domain-containing protein 158

  4. XM_036152876.1 → XP_036008769.1  outer dynein arm-docking complex subunit 1 isoform X9

    Conserved Domains (1) summary
    COG1196
    Location:30 → 307
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  5. XM_006540769.5 → XP_006540832.1  outer dynein arm-docking complex subunit 1 isoform X3

    Conserved Domains (2) summary
    TIGR02168
    Location:30 → 317
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:472 → 564
    CCDC158; Coiled-coil domain-containing protein 158

  6. XM_036152875.1 → XP_036008768.1  outer dynein arm-docking complex subunit 1 isoform X7

    Conserved Domains (1) summary
    TIGR02168
    Location:30 → 412
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  7. XM_036152873.1 → XP_036008766.1  outer dynein arm-docking complex subunit 1 isoform X4

    UniProtKB/Swiss-Prot
    Q3UX62, Q91WT0
    Conserved Domains (1) summary
    COG1196
    Location:30 → 158
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  8. XM_006540764.4 → XP_006540827.1  outer dynein arm-docking complex subunit 1 isoform X1

    See identical proteins and their annotated locations for XP_006540827.1

    UniProtKB/TrEMBL
    A0A1B0GR16
    Conserved Domains (2) summary
    TIGR02168
    Location:30 → 317
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:472 → 564
    CCDC158; Coiled-coil domain-containing protein 158

  9. XM_006540766.4 → XP_006540829.1  outer dynein arm-docking complex subunit 1 isoform X1

    See identical proteins and their annotated locations for XP_006540829.1

    UniProtKB/TrEMBL
    A0A1B0GR16
    Conserved Domains (2) summary
    TIGR02168
    Location:30 → 317
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:472 → 564
    CCDC158; Coiled-coil domain-containing protein 158

  10. XM_006540768.4 → XP_006540831.1  outer dynein arm-docking complex subunit 1 isoform X2

    UniProtKB/Swiss-Prot
    Q3UX62, Q91WT0
    Related
    ENSMUST00000210867.2
    Conserved Domains (2) summary
    TIGR02169
    Location:4 → 250
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam15921
    Location:405 → 497
    CCDC158; Coiled-coil domain-containing protein 158

  11. XM_036152874.1 → XP_036008767.1  outer dynein arm-docking complex subunit 1 isoform X4

    UniProtKB/Swiss-Prot
    Q3UX62, Q91WT0
    Conserved Domains (1) summary
    COG1196
    Location:30 → 158
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  12. XM_006540773.1 → XP_006540836.1  outer dynein arm-docking complex subunit 1 isoform X6

    Conserved Domains (1) summary
    pfam15921
    Location:241 → 333
    CCDC158; Coiled-coil domain-containing protein 158

RNA

  1. XR_003946431.2 RNA Sequence

  2. XR_004934052.1 RNA Sequence

  3. XR_004934053.1 RNA Sequence

  4. XR_391330.4 RNA Sequence

  5. XR_003946432.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001033243.2: Suppressed sequence

    Description
    NM_001033243.2: This RefSeq was removed because currently there is insufficient support for the transcript and protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UX62.1 GenPept UniProtKB/Swiss-Prot:Q3UX62

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