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Suox sulfite oxidase [ Mus musculus (house mouse) ]

Gene ID: 211389, updated on 5-Mar-2024

Summary

Official Symbol
Suoxprovided by MGI
Official Full Name
sulfite oxidaseprovided by MGI
Primary source
MGI:MGI:2446117
See related
Ensembl:ENSMUSG00000049858 AllianceGenome:MGI:2446117
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SO
Summary
Predicted to enable heme binding activity; molybdopterin cofactor binding activity; and sulfite oxidase activity. Predicted to be involved in response to nutrient and sulfur compound metabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in inherited metabolic disorder and isolated sulfite oxidase deficiency. Orthologous to human SUOX (sulfite oxidase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in large intestine adult (RPKM 75.1), genital fat pad adult (RPKM 64.7) and 23 other tissues See more
Orthologs
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Genomic context

See Suox in Genome Data Viewer
Location:
10 D3; 10 77.12 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (128505756..128509787, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (128669887..128673918, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene IKAROS family zinc finger 4 Neighboring gene predicted gene, 26876 Neighboring gene predicted gene, 51824 Neighboring gene STARR-positive B cell enhancer ABC_E2343 Neighboring gene ribosomal protein L12 pseudogene Neighboring gene RAB5B, member RAS oncogene family Neighboring gene STARR-positive B cell enhancer ABC_E50 Neighboring gene STARR-positive B cell enhancer ABC_E2974 Neighboring gene premelanosome protein Neighboring gene cyclin dependent kinase 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC28458

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables heme binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables molybdenum ion binding IEA
Inferred from Electronic Annotation
more info
 
enables molybdopterin cofactor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables molybdopterin cofactor binding ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables sulfite oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables sulfite oxidase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in response to nutrient ISO
Inferred from Sequence Orthology
more info
 
involved_in sulfur compound metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
sulfite oxidase, mitochondrial
NP_776094.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173733.3NP_776094.2  sulfite oxidase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_776094.2

    Status: VALIDATED

    Source sequence(s)
    AC117232
    Consensus CDS
    CCDS24285.1
    UniProtKB/Swiss-Prot
    Q3U3S5, Q3UEP6, Q8R086
    Related
    ENSMUSP00000056195.8, ENSMUST00000054764.9
    Conserved Domains (3) summary
    PLN00177
    Location:169544
    PLN00177; sulfite oxidase; Provisional
    cd02111
    Location:186544
    eukary_SO_Moco; molybdopterin binding domain of sulfite oxidase (SO). SO catalyzes the terminal reaction in the oxidative degradation of the sulfur-containing amino acids cysteine and methionine. Common features of all known members of the sulfite oxidase (SO) family of ...
    pfam00173
    Location:85161
    Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    128505756..128509787 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)