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Kbtbd7 kelch repeat and BTB (POZ) domain containing 7 [ Mus musculus (house mouse) ]

Gene ID: 211255, updated on 5-Mar-2024

Summary

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Official Symbol
Kbtbd7provided by MGI
Official Full Name
kelch repeat and BTB (POZ) domain containing 7provided by MGI
Primary source
MGI:MGI:2685141
See related
Ensembl:ENSMUSG00000043881 AllianceGenome:MGI:2685141
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm295; 1110008P08Rik
Summary
Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process; protein K48-linked ubiquitination; and regulation of Rac protein signal transduction. Predicted to be part of Cul3-RING ubiquitin ligase complex. Is expressed in embryo. Orthologous to human KBTBD7 (kelch repeat and BTB domain containing 7). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human all
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Genomic context

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Location:
14 D3; 14 42.65 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (79663951..79668479)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (79426511..79431039)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:79691968-79692228 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:79693274-79693461 Neighboring gene regulator of cell cycle Neighboring gene N(alpha)-acetyltransferase 16, NatA auxiliary subunit Neighboring gene STARR-positive B cell enhancer ABC_E11576 Neighboring gene STARR-positive B cell enhancer ABC_E4121 Neighboring gene STARR-positive B cell enhancer ABC_E7342 Neighboring gene STARR-positive B cell enhancer ABC_E7343 Neighboring gene STARR-positive B cell enhancer ABC_E4122 Neighboring gene mitochondrial translational release factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E2429 Neighboring gene kelch repeat and BTB (POZ) domain containing 6 Neighboring gene WW domain binding protein 4 Neighboring gene E74 like ETS transcription factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. New TFII-I family target genes involved in embryonic development. Makeyev AV, et al. Biochem Biophys Res Commun, 2009 Sep 4. PMID 19527686, Free PMC Article
  2. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of Rac protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
kelch repeat and BTB domain-containing protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024135.2 → NP_001019306.2  kelch repeat and BTB domain-containing protein 7

    See identical proteins and their annotated locations for NP_001019306.2

    Status: VALIDATED

    Source sequence(s)
    BC096019, CO045548
    Consensus CDS
    CCDS27298.1
    UniProtKB/TrEMBL
    G5E8C2, Q501K2
    Related
    ENSMUSP00000060768.8, ENSMUST00000061222.9
    Conserved Domains (5) summary
    smart00875
    Location:173 → 274
    BACK; BTB And C-terminal Kelch
    PHA03098
    Location:55 → 554
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:394 → 431
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:53 → 164
    BTB; BTB/POZ domain
    pfam01344
    Location:435 → 481
    Kelch_1; Kelch motif

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    79663951..79668479
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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