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Mtrf1 mitochondrial translational release factor 1 [ Mus musculus (house mouse) ]

Gene ID: 211253, updated on 5-Mar-2024

Summary

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Official Symbol
Mtrf1provided by MGI
Official Full Name
mitochondrial translational release factor 1provided by MGI
Primary source
MGI:MGI:2384815
See related
Ensembl:ENSMUSG00000022022 AllianceGenome:MGI:2384815
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MtRF-1; A830062K05Rik
Summary
Predicted to enable translation release factor activity. Predicted to be involved in mitochondrial translational termination. Predicted to act upstream of or within translation. Located in mitochondrion. Orthologous to human MTRF1 (mitochondrial translation release factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 2.2), CNS E11.5 (RPKM 2.2) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Mtrf1 in Genome Data Viewer
Location:
14 D3; 14 42.63 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (79635205..79672626)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (79397765..79423650)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:79691968-79692228 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:79693274-79693461 Neighboring gene regulator of cell cycle Neighboring gene N(alpha)-acetyltransferase 16, NatA auxiliary subunit Neighboring gene STARR-positive B cell enhancer ABC_E11576 Neighboring gene STARR-positive B cell enhancer ABC_E4121 Neighboring gene STARR-positive B cell enhancer ABC_E7342 Neighboring gene STARR-positive B cell enhancer ABC_E7343 Neighboring gene STARR-positive B cell enhancer ABC_E4122 Neighboring gene kelch repeat and BTB (POZ) domain containing 7 Neighboring gene STARR-positive B cell enhancer ABC_E2429 Neighboring gene kelch repeat and BTB (POZ) domain containing 6 Neighboring gene WW domain binding protein 4 Neighboring gene E74 like ETS transcription factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic, morphometric, and behavioral factors linked to the midsagittal area of the corpus callosum. Newbury AJ, et al. Front Genet, 2012. PMID 22666227, Free PMC Article
  2. RONIN Is an Essential Transcriptional Regulator of Genes Required for Mitochondrial Function in the Developing Retina. Poché RA, et al. Cell Rep, 2016 Feb 23. PMID 26876175, Free PMC Article
  3. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
  4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC19099

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables translation release factor activity IEA
Inferred from Electronic Annotation
more info
  
enables translation release factor activity, codon specific ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in mitochondrial translational termination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial translational termination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational termination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
peptide chain release factor 1, mitochondrial
Names
MRF-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145960.4 → NP_666072.3  peptide chain release factor 1, mitochondrial

    See identical proteins and their annotated locations for NP_666072.3

    Status: VALIDATED

    Source sequence(s)
    AC124745, AK043981, BB620002
    Consensus CDS
    CCDS27297.1
    UniProtKB/Swiss-Prot
    Q8K126
    UniProtKB/TrEMBL
    Q8BJY8
    Related
    ENSMUSP00000022600.3, ENSMUST00000022600.4
    Conserved Domains (3) summary
    COG0216
    Location:72 → 440
    PrfA; Protein chain release factor A [Translation, ribosomal structure and biogenesis]
    pfam00472
    Location:293 → 398
    RF-1; RF-1 domain
    pfam03462
    Location:105 → 283
    PCRF; PCRF domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    79635205..79672626
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158531.1 → XP_036014424.1  peptide chain release factor 1, mitochondrial isoform X3

    UniProtKB/TrEMBL
    Q8BJY8
    Conserved Domains (1) summary
    cl40670
    Location:116 → 423
    PCRF; PCRF domain

  2. XM_036158530.1 → XP_036014423.1  peptide chain release factor 1, mitochondrial isoform X2

    UniProtKB/TrEMBL
    Q8BJY8
    Conserved Domains (1) summary
    cl40670
    Location:116 → 428
    PCRF; PCRF domain

  3. XM_017315939.2 → XP_017171428.1  peptide chain release factor 1, mitochondrial isoform X1

    UniProtKB/TrEMBL
    Q8BJY8
    Conserved Domains (1) summary
    PRK00591
    Location:116 → 452
    prfA; peptide chain release factor 1; Validated

RNA

  1. XR_003950832.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K126.1 GenPept UniProtKB/Swiss-Prot:Q8K126

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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