U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Lrrc25 leucine rich repeat containing 25 [ Mus musculus (house mouse) ]

Gene ID: 211228, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Lrrc25provided by MGI
Official Full Name
leucine rich repeat containing 25provided by MGI
Primary source
MGI:MGI:2445284
See related
Ensembl:ENSMUSG00000049988 AllianceGenome:MGI:2445284
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mapa
Summary
Predicted to be located in cytoplasm and membrane. Predicted to be integral component of membrane. Orthologous to human LRRC25 (leucine rich repeat containing 25). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen adult (RPKM 29.7), mammary gland adult (RPKM 15.4) and 20 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
8 B3.3; 8 34.15 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (71068810..71073501)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (70616844..70620850)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1369 Neighboring gene myo-inositol 1-phosphate synthase A1 Neighboring gene single stranded DNA binding protein 4 Neighboring gene STARR-positive B cell enhancer ABC_E3777 Neighboring gene STARR-positive B cell enhancer ABC_E3778 Neighboring gene STARR-positive B cell enhancer ABC_E3779 Neighboring gene STARR-positive B cell enhancer ABC_E6645 Neighboring gene STARR-seq mESC enhancer starr_21778 Neighboring gene growth differentiation factor 15 Neighboring gene predicted gene, 34154

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Loss of LRRC25 accelerates pathological cardiac hypertrophy through promoting fibrosis and inflammation regulated by TGF-β1. Zhang X, et al. Biochem Biophys Res Commun, 2018 Nov 17. PMID 30340835
  2. Subtractive hybridization reveals the expression of immunoglobulin-like transcript 7, Eph-B1, granzyme B, and 3 novel transcripts in human plasmacytoid dendritic cells. Rissoan MC, et al. Blood, 2002 Nov 1. PMID 12384430
  3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LRRC25 as a critical molecular switch whose down-regulation resulted in cardiac hypertrophy in a TGF-beta1- and NF-kappaB-dependent manner.
    Title: Loss of LRRC25 accelerates pathological cardiac hypertrophy through promoting fibrosis and inflammation regulated by TGF-β1.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
leucine-rich repeat-containing protein 25
Names
monocyte and plasmacytoid activated molecule
monocyte and plasmacytoid-activated protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153074.4 → NP_694714.1  leucine-rich repeat-containing protein 25 precursor

    See identical proteins and their annotated locations for NP_694714.1

    Status: VALIDATED

    Source sequence(s)
    AC157774
    Consensus CDS
    CCDS22375.1
    UniProtKB/Swiss-Prot
    Q3TAD5, Q8K1T1
    UniProtKB/TrEMBL
    B9EHD0
    Related
    ENSMUSP00000049686.4, ENSMUST00000052437.6
    Conserved Domains (2) summary
    sd00031
    Location:68 → 90
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:65 → 105
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    71068810..71073501
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153854.1 → XP_036009747.1  leucine-rich repeat-containing protein 25 isoform X1

    UniProtKB/Swiss-Prot
    Q3TAD5, Q8K1T1
    UniProtKB/TrEMBL
    B9EHD0
    Conserved Domains (2) summary
    sd00031
    Location:68 → 90
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:65 → 105
    LRR_8; Leucine rich repeat
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K1T1.1 GenPept UniProtKB/Swiss-Prot:Q8K1T1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous