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Marchf11 membrane associated ring-CH-type finger 11 [ Mus musculus (house mouse) ]

Gene ID: 211147, updated on 11-Apr-2024

Summary

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Official Symbol
Marchf11provided by MGI
Official Full Name
membrane associated ring-CH-type finger 11provided by MGI
Primary source
MGI:MGI:3608327
See related
Ensembl:ENSMUSG00000022269 AllianceGenome:MGI:3608327
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
March11; 9630025C22
Summary
Predicted to enable transferase activity and zinc ion binding activity. Predicted to be located in cytoplasmic vesicle and membrane. Predicted to be integral component of membrane. Orthologous to human MARCHF11 (membrane associated ring-CH-type finger 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 147.5) See more
Orthologs
human all
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Genomic context

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Location:
15 B1; 15 9.77 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (26309134..26409672)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (26309048..26409586)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_38204 Neighboring gene predicted gene, 41279 Neighboring gene STARR-seq mESC enhancer starr_38206 Neighboring gene predicted gene, 57625 Neighboring gene STARR-seq mESC enhancer starr_38207 Neighboring gene predicted gene, 52201 Neighboring gene STARR-seq mESC enhancer starr_38209 Neighboring gene STARR-seq mESC enhancer starr_38210 Neighboring gene predicted gene, 36790 Neighboring gene predicted gene, 52206 Neighboring gene F-box and leucine-rich repeat protein 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of SAMT family proteins as substrates of MARCH11 in mouse spermatids. Yogo K, et al. Histochem Cell Biol, 2012 Jan. PMID 22075566
  2. Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice. Miyata H, et al. Proc Natl Acad Sci U S A, 2016 Jul 12. PMID 27357688, Free PMC Article
  3. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article
  4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase MARCHF11
Names
E3 ubiquitin-protein ligase MARCH11
MARCH-XI
RING-type E3 ubiquitin transferase MARCH11
RING-type E3 ubiquitin transferase MARCHF11
membrane-associated RING finger protein 11
membrane-associated RING-CH protein XI
membrane-associated ring finger (C3HC4) 11
NP_001297703.1
NP_808265.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310774.1 → NP_001297703.1  E3 ubiquitin-protein ligase MARCHF11 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon, which results in a frameshift compared to variant 1. The resulting isoform (2) is shorter with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK035990, AK162044, BF467885
    Consensus CDS
    CCDS79365.1
    UniProtKB/TrEMBL
    D3YXE6
    Related
    ENSMUSP00000120622.2, ENSMUST00000152841.2
    Conserved Domains (1) summary
    smart00744
    Location:167 → 213
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

  2. NM_177597.6 → NP_808265.2  E3 ubiquitin-protein ligase MARCHF11 isoform 1

    See identical proteins and their annotated locations for NP_808265.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK035990, AK162044, BF467885, BU961611
    Consensus CDS
    CCDS27401.2
    UniProtKB/Swiss-Prot
    B9EIG0, Q8CBH7
    Related
    ENSMUSP00000118729.2, ENSMUST00000140840.8
    Conserved Domains (1) summary
    smart00744
    Location:167 → 213
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    26309134..26409672
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CBH7.2 GenPept UniProtKB/Swiss-Prot:Q8CBH7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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