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Lzts1 leucine zipper, putative tumor suppressor 1 [ Mus musculus (house mouse) ]

Gene ID: 211134, updated on 21-Apr-2024

Summary

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Official Symbol
Lzts1provided by MGI
Official Full Name
leucine zipper, putative tumor suppressor 1provided by MGI
Primary source
MGI:MGI:2684762
See related
Ensembl:ENSMUSG00000036306 AllianceGenome:MGI:2684762
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
F37; FEZ1; PSD-Zip70
Summary
Predicted to enable microtubule binding activity. Predicted to be involved in negative regulation of macroautophagy; regulation of dendrite morphogenesis; and regulation of synaptic plasticity. Predicted to be located in several cellular components, including apical plasma membrane; dendritic shaft; and postsynaptic density. Predicted to be active in dendritic spine. Is expressed in several structures, including brain and metanephros. Human ortholog(s) of this gene implicated in esophageal cancer and squamous cell carcinoma. Orthologous to human LZTS1 (leucine zipper tumor suppressor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 14.3), cortex adult (RPKM 13.3) and 14 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 B3.3; 8 33.88 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (69585311..69636901, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (69132659..69184249, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33103 Neighboring gene predicted gene, 33052 Neighboring gene STARR-seq mESC enhancer starr_21713 Neighboring gene STARR-seq mESC enhancer starr_21714 Neighboring gene solute carrier family 18 (vesicular monoamine), member 1 Neighboring gene STARR-positive B cell enhancer ABC_E8237 Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit B2 Neighboring gene STARR-positive B cell enhancer ABC_E8238 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:71645510-71645697 Neighboring gene predicted gene, 39187 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:71700363-71700564 Neighboring gene STARR-positive B cell enhancer ABC_E6640 Neighboring gene STARR-positive B cell enhancer ABC_E3775 Neighboring gene STARR-seq mESC enhancer starr_21725 Neighboring gene predicted gene, 39188 Neighboring gene zinc finger protein 930 Neighboring gene predicted gene, 33178

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Social Stress-Induced Postsynaptic Hyporesponsiveness in Glutamatergic Synapses Is Mediated by PSD-Zip70-Rap2 Pathway and Relates to Anxiety-Like Behaviors. Mayanagi T, et al. Front Cell Neurosci, 2019. PMID 31969804, Free PMC Article
  2. PSD-Zip70 Deficiency Causes Prefrontal Hypofunction Associated with Glutamatergic Synapse Maturation Defects by Dysregulation of Rap2 Activity. Mayanagi T, et al. J Neurosci, 2015 Oct 21. PMID 26490870, Free PMC Article
  3. Fez1/Lzts1-deficient mice are more susceptible to N-butyl-N-(4-hydroxybutil) nitrosamine (BBN) carcinogenesis. Baffa R, et al. Carcinogenesis, 2008 Apr. PMID 18192690
  4. Lzts1 controls both neuronal delamination and outer radial glial-like cell generation during mammalian cerebral development. Kawaue T, et al. Nat Commun, 2019 Jun 25. PMID 31239441, Free PMC Article
  5. Timing is everything: regulation of Cdk1 and aneuploidy. Tsichlis PN, et al. Dev Cell, 2007 Apr. PMID 17419986

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lzts1 functions as a master modulator of cellular dynamics, contributing to increasing complexity of the cerebral architecture during evolution.
    Title: Lzts1 controls both neuronal delamination and outer radial glial-like cell generation during mammalian cerebral development.
  2. The results of this study provide a novel Rap2-specific regulatory mechanism in synaptic maturation involving PSD-Zip70.
    Title: PSD-Zip70 Deficiency Causes Prefrontal Hypofunction Associated with Glutamatergic Synapse Maturation Defects by Dysregulation of Rap2 Activity.
  3. Taken together, the spatial and temporal distribution of Lzts1 is consistent with a potential function(s) in cell cycle regulation, axon growth or guidance, and/or migration of neurons.
    Title: The expression profile of the tumor suppressor gene Lzts1 suggests a role in neuronal development.
  4. Loss of one or both LZTS1 alleles hampers the normal defenses of urothelial cells against carcinogens, favoring bladder cancer development, which may make FEZ1 a target for gene therapy.
    Title: Fez1/Lzts1-deficient mice are more susceptible to N-butyl-N-(4-hydroxybutil) nitrosamine (BBN) carcinogenesis.
  5. Lzts1 deficiency was associated with an increased incidence of both spontaneous and carcinogen-induced cancers in mice.
    Title: Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development.
  6. Partial or complete loss of Lzts1 downregulates Cdc25C and inhibits Cdk1 activity during mitosis, leading to premature transition from metaphase to anaphase.
    Title: Timing is everything: regulation of Cdk1 and aneuploidy.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of macroautophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of dendrite morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of dendrite morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of postsynapse assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of postsynapse assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of synaptic plasticity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of synaptic plasticity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cell body ISO
Inferred from Sequence Orthology
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in dendritic shaft ISO
Inferred from Sequence Orthology
more info
  
is_active_in dendritic spine IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
leucine zipper putative tumor suppressor 1
Names
F37 esophageal cancer-related leucine zipper motif 1
F37/Esophageal cancer-related gene-coding leucine-zipper motif
leucine-zipper protein FEZ1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001370971.1 → NP_001357900.1  leucine zipper putative tumor suppressor 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC114995
    Consensus CDS
    CCDS22345.1
    UniProtKB/Swiss-Prot
    B2RTI1, P60853
    UniProtKB/TrEMBL
    A0PJT4
    Related
    ENSMUSP00000139117.2, ENSMUST00000185176.8
    Conserved Domains (2) summary
    COG1196
    Location:210 → 480
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam06818
    Location:378 → 567
    Fez1

  2. NM_199364.3 → NP_955396.2  leucine zipper putative tumor suppressor 1

    See identical proteins and their annotated locations for NP_955396.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC114995
    Consensus CDS
    CCDS22345.1
    UniProtKB/Swiss-Prot
    B2RTI1, P60853
    UniProtKB/TrEMBL
    A0PJT4
    Conserved Domains (2) summary
    COG1196
    Location:210 → 480
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam06818
    Location:378 → 567
    Fez1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    69585311..69636901 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509608.5 → XP_006509671.1  leucine zipper putative tumor suppressor 1 isoform X1

    See identical proteins and their annotated locations for XP_006509671.1

    UniProtKB/Swiss-Prot
    B2RTI1, P60853
    UniProtKB/TrEMBL
    A0PJT4
    Conserved Domains (2) summary
    COG1196
    Location:210 → 480
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam06818
    Location:378 → 567
    Fez1

  2. XM_030243384.2 → XP_030099244.1  leucine zipper putative tumor suppressor 1 isoform X1

    UniProtKB/Swiss-Prot
    B2RTI1, P60853
    UniProtKB/TrEMBL
    A0PJT4
    Conserved Domains (2) summary
    COG1196
    Location:210 → 480
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam06818
    Location:378 → 567
    Fez1

  3. XM_030243385.2 → XP_030099245.1  leucine zipper putative tumor suppressor 1 isoform X1

    UniProtKB/Swiss-Prot
    B2RTI1, P60853
    UniProtKB/TrEMBL
    A0PJT4
    Conserved Domains (2) summary
    COG1196
    Location:210 → 480
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam06818
    Location:378 → 567
    Fez1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P60853.3 GenPept UniProtKB/Swiss-Prot:P60853

Gene LinkOut

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