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Sepsecs Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase [ Mus musculus (house mouse) ]

Gene ID: 211006, updated on 21-Apr-2024

Summary

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Official Symbol
Sepsecsprovided by MGI
Official Full Name
Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthaseprovided by MGI
Primary source
MGI:MGI:1098791
See related
Ensembl:ENSMUSG00000029173 AllianceGenome:MGI:1098791
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SLA; SecS; D5Ertd135e
Summary
Enables tRNA binding activity. Involved in selenocysteine incorporation. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; limb; musculoskeletal system; and respiratory system. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 2D. Orthologous to human SEPSECS (Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 4.8), liver adult (RPKM 4.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 C1; 5 28.44 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (52797431..52827104, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (52640089..52669764, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 8030423F21 gene Neighboring gene predicted gene, 30178 Neighboring gene STARR-seq mESC enhancer starr_13066 Neighboring gene STARR-seq mESC enhancer starr_13067 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:53060867-53061054 Neighboring gene STARR-seq mESC enhancer starr_13069 Neighboring gene phosphatidylinositol 4-kinase type 2 beta Neighboring gene zinc finger, CCHC domain containing 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of CD4 T-cell epitopes in soluble liver antigen/liver pancreas autoantigen in autoimmune hepatitis. Mix H, et al. Gastroenterology, 2008 Dec. PMID 18773898, Free PMC Article
  2. Structure and catalytic mechanism of eukaryotic selenocysteine synthase. Ganichkin OM, et al. J Biol Chem, 2008 Feb 29. PMID 18093968
  3. Missense mutation in selenocysteine synthase causes cardio-respiratory failure and perinatal death in mice which can be compensated by selenium-independent GPX4. Fradejas-Villar N, et al. Redox Biol, 2021 Nov 12. PMID 34794077, Free PMC Article
  4. Biosynthesis of selenocysteine on its tRNA in eukaryotes. Xu XM, et al. PLoS Biol, 2007 Jan. PMID 17194211, Free PMC Article
  5. Supramolecular complexes mediate selenocysteine incorporation in vivo. Small-Howard A, et al. Mol Cell Biol, 2006 Mar. PMID 16508009, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SECp43 and SLA have roles in selenoprotein synthesis [soluble liver antigen]
    Title: Evidence for direct roles of two additional factors, SECp43 and soluble liver antigen, in the selenoprotein synthesis machinery.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • 9130208G10

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables O-phosphoseryl-tRNA(Sec) selenium transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in conversion of seryl-tRNAsec to selenocys-tRNAsec IEA
Inferred from Electronic Annotation
more info
  
involved_in selenocysteine incorporation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in selenocysteine incorporation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
O-phosphoseryl-tRNA(Sec) selenium transferase
Names
UGA suppressor tRNA-associated protein
selenocysteinyl-tRNA(Sec) synthase
NP_001350392.1
NP_766078.1
XP_006503890.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363463.1 → NP_001350392.1  O-phosphoseryl-tRNA(Sec) selenium transferase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK153792
    UniProtKB/TrEMBL
    Q3U597
    Conserved Domains (1) summary
    cl18945
    Location:1 → 317
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

  2. NM_172490.4 → NP_766078.1  O-phosphoseryl-tRNA(Sec) selenium transferase isoform 1

    See identical proteins and their annotated locations for NP_766078.1

    Status: VALIDATED

    Source sequence(s)
    AC120128
    Consensus CDS
    CCDS19286.1
    UniProtKB/Swiss-Prot
    Q6P6M7, Q8BZS6
    Related
    ENSMUSP00000031069.7, ENSMUST00000031069.13
    Conserved Domains (1) summary
    TIGR03531
    Location:13 → 458
    selenium_SpcS; O-phosphoseryl-tRNA(Sec) selenium transferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    52797431..52827104 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503827.5 → XP_006503890.1  O-phosphoseryl-tRNA(Sec) selenium transferase isoform X1

    Conserved Domains (1) summary
    cl18945
    Location:13 → 268
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P6M7.2 GenPept UniProtKB/Swiss-Prot:Q6P6M7

Gene LinkOut

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