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Kcnk12 potassium channel, subfamily K, member 12 [ Mus musculus (house mouse) ]

Gene ID: 210741, updated on 5-Mar-2024

Summary

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Official Symbol
Kcnk12provided by MGI
Official Full Name
potassium channel, subfamily K, member 12provided by MGI
Primary source
MGI:MGI:2684043
See related
Ensembl:ENSMUSG00000050138 AllianceGenome:MGI:2684043
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mntk1
Summary
Predicted to enable potassium ion leak channel activity. Predicted to be involved in potassium ion transmembrane transport and stabilization of membrane potential. Predicted to be integral component of plasma membrane. Orthologous to human KCNK12 (potassium two pore domain channel subfamily K member 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 13.2), ovary adult (RPKM 10.6) and 6 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 E4; 17 57.87 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (88049100..88106329, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (87745821..87797994, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene epithelial cell adhesion molecule Neighboring gene STARR-seq mESC enhancer starr_43514 Neighboring gene STARR-positive B cell enhancer ABC_E7565 Neighboring gene STARR-seq mESC enhancer starr_43516 Neighboring gene mutS homolog 2 Neighboring gene STARR-seq mESC enhancer starr_43518 Neighboring gene STARR-seq mESC enhancer starr_43519 Neighboring gene STARR-seq mESC enhancer starr_43521 Neighboring gene predicted gene, 41649 Neighboring gene STARR-seq mESC enhancer starr_43523 Neighboring gene STARR-seq mESC enhancer starr_43524 Neighboring gene STARR-seq mESC enhancer starr_43525 Neighboring gene STARR-seq mESC enhancer starr_43526 Neighboring gene STARR-seq mESC enhancer starr_43527 Neighboring gene ribosomal protein L36, pseudogene 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cellular localization of THIK-1 (K(2P)13.1) and THIK-2 (K(2P)12.1) K channels in the mammalian kidney. Theilig F, et al. Cell Physiol Biochem, 2008. PMID 18209473
  2. Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development. Harrell MD, et al. Physiol Genomics, 2007 Feb 12. PMID 16985003
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. THIK-1 and THIK-2 are abundantly expressed in the proximal and distal nephron of the mammalian kidney.
    Title: Cellular localization of THIK-1 (K(2P)13.1) and THIK-2 (K(2P)12.1) K channels in the mammalian kidney.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables outward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables potassium ion leak channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in stabilization of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
potassium channel subfamily K member 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199251.1 → NP_954859.1  potassium channel subfamily K member 12

    See identical proteins and their annotated locations for NP_954859.1

    Status: VALIDATED

    Source sequence(s)
    AB052939
    Consensus CDS
    CCDS29020.1
    UniProtKB/TrEMBL
    Q76M80
    Related
    ENSMUSP00000053595.8, ENSMUST00000055221.9
    Conserved Domains (1) summary
    pfam07885
    Location:222 → 304
    Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    88049100..88106329 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160433.1 → XP_036016326.1  potassium channel subfamily K member 12 isoform X1

    Conserved Domains (1) summary
    pfam07885
    Location:116 → 198
    Ion_trans_2; Ion channel

  2. XM_036160434.1 → XP_036016327.1  potassium channel subfamily K member 12 isoform X2

    Conserved Domains (1) summary
    pfam07885
    Location:89 → 171
    Ion_trans_2; Ion channel
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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