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Pamr1 peptidase domain containing associated with muscle regeneration 1 [ Mus musculus (house mouse) ]

Gene ID: 210622, updated on 28-Apr-2024

Summary

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Official Symbol
Pamr1provided by MGI
Official Full Name
peptidase domain containing associated with muscle regeneration 1provided by MGI
Primary source
MGI:MGI:2445082
See related
Ensembl:ENSMUSG00000027188 AllianceGenome:MGI:2445082
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ramp; 5930437L24; E430002G05Rik
Summary
Predicted to enable calcium ion binding activity and serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. Is expressed in several structures, including alimentary system; brain ventricular layer; limb; metanephros; and skeleton. Orthologous to human PAMR1 (peptidase domain containing associated with muscle regeneration 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 20.9), limb E14.5 (RPKM 13.3) and 17 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 E2; 2 54.13 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (102380325..102473386)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (102549939..102643041)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_05252 Neighboring gene predicted gene, 39890 Neighboring gene four jointed box 1 Neighboring gene STARR-seq mESC enhancer starr_05255 Neighboring gene STARR-seq mESC enhancer starr_05256 Neighboring gene STARR-seq mESC enhancer starr_05257 Neighboring gene STARR-seq mESC enhancer starr_05258 Neighboring gene predicted gene, 57687 Neighboring gene solute carrier family 1 (glial high affinity glutamate transporter), member 2 Neighboring gene STARR-positive B cell enhancer ABC_E2631 Neighboring gene predicted gene 13872

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The single EGF-like domain of mouse PAMR1 is modified by O-Glucose, O-Fucose and O-GlcNAc. Pennarubia F, et al. Glycobiology, 2021 Jan 9. PMID 32518939
  2. Cloning of cDNA encoding a regeneration-associated muscle protease whose expression is attenuated in cell lines derived from Duchenne muscular dystrophy patients. Nakayama Y, et al. Am J Pathol, 2004 May. PMID 15111323, Free PMC Article
  3. An Islet-Targeted Genome-Wide Association Scan Identifies Novel Genes Implicated in Cytokine-Mediated Islet Stress in Type 2 Diabetes. Sharma PR, et al. Endocrinology, 2015 Sep. PMID 26018251, Free PMC Article
  4. βlinc1 encodes a long noncoding RNA that regulates islet β-cell formation and function. Arnes L, et al. Genes Dev, 2016 Mar 1. PMID 26944677, Free PMC Article
  5. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The single EGF-like domain of mouse PAMR1 is modified by O-Glucose, O-Fucose and O-GlcNAc.
    Title: The single EGF-like domain of mouse PAMR1 is modified by O-Glucose, O-Fucose and O-GlcNAc.
  2. related to islet dysfunction during the development of type 2 diabetes
    Title: An Islet-Targeted Genome-Wide Association Scan Identifies Novel Genes Implicated in Cytokine-Mediated Islet Stress in Type 2 Diabetes.
  3. RAMP may play a role in the regeneration of skeletal muscle, and its down-regulation could be involved in the progression of Duchenne muscular dystrophy
    Title: Cloning of cDNA encoding a regeneration-associated muscle protease whose expression is attenuated in cell lines derived from Duchenne muscular dystrophy patients.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
inactive serine protease PAMR1
Names
peptidase domain-containing protein associated with muscle regeneration 1
regeneration associated muscle protease
regeneration-associated muscle protease homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173749.4 → NP_776110.3  inactive serine protease PAMR1 precursor

    See identical proteins and their annotated locations for NP_776110.3

    Status: VALIDATED

    Source sequence(s)
    AA444868, AL844605, BB620582, BY264071, BY266233, CX564812
    Consensus CDS
    CCDS16468.1
    UniProtKB/Swiss-Prot
    A2AQI2, Q8BU25, Q8K2B8
    Related
    ENSMUSP00000028612.8, ENSMUST00000028612.8
    Conserved Domains (5) summary
    cd00033
    Location:280 → 342
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00020
    Location:461 → 715
    Tryp_SPc; Trypsin-like serine protease
    cd00041
    Location:128 → 234
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00054
    Location:240 → 272
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00190
    Location:461 → 718
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    102380325..102473386
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160219.1 → XP_036016112.1  inactive serine protease PAMR1 isoform X1

    Conserved Domains (3) summary
    cd00033
    Location:280 → 342
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd00041
    Location:128 → 234
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00054
    Location:240 → 272
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BU25.3 GenPept UniProtKB/Swiss-Prot:Q8BU25

Gene LinkOut

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