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Timd5 T cell immunoglobulin and mucin domain containing 5 [ Mus musculus (house mouse) ]

Gene ID: 210535, updated on 8-Feb-2024

Summary

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Official Symbol
Timd5provided by MGI
Official Full Name
T cell immunoglobulin and mucin domain containing 5provided by MGI
Primary source
MGI:MGI:3650838
See related
Ensembl:ENSMUSG00000078924 AllianceGenome:MGI:3650838
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm12169
Summary
Predicted to enable phosphatidylserine binding activity and virus receptor activity. Predicted to be involved in phagocytosis, engulfment and positive regulation of mast cell activation. Predicted to be active in cell surface. Human ortholog(s) of this gene implicated in atopic dermatitis. Orthologous to human HAVCR1 (hepatitis A virus cellular receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
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Genomic context

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Location:
11 B1.1; 11 27.98 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (46415078..46428983)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (46524251..46538156)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12168 Neighboring gene hepatitis A virus cellular receptor 2 Neighboring gene STARR-seq mESC enhancer starr_29329 Neighboring gene developmental pluripotency associated 1 family member pseudogene Neighboring gene ribosomal protein L9, pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  2. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phosphatidylserine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables virus receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables virus receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in phagocytosis, engulfment IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of mast cell activation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in motile cilium ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
Hepatitis A virus cellular receptor 1 homolog-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163357.1 → NP_001156829.1  Hepatitis A virus cellular receptor 1 homolog-like precursor

    Status: PROVISIONAL

    Source sequence(s)
    AL669948
    Consensus CDS
    CCDS48777.1
    UniProtKB/TrEMBL
    F2Z474
    Related
    ENSMUSP00000104851.2, ENSMUST00000109228.2
    Conserved Domains (2) summary
    smart00410
    Location:23 → 127
    IG_like; Immunoglobulin like
    pfam07686
    Location:23 → 110
    V-set; Immunoglobulin V-set domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    46415078..46428983
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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