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Zfp677 zinc finger protein 677 [ Mus musculus (house mouse) ]

Gene ID: 210503, updated on 8-Feb-2024

Summary

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Official Symbol
Zfp677provided by MGI
Official Full Name
zinc finger protein 677provided by MGI
Primary source
MGI:MGI:3053207
See related
Ensembl:ENSMUSG00000062743 AllianceGenome:MGI:3053207
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tce8; A830058L05Rik
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nuclear body and nucleolus. Predicted to be active in nucleus. Is expressed in early conceptus and genitourinary system. Orthologous to human ZNF300 (zinc finger protein 300). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 2.1), CNS E18 (RPKM 1.2) and 20 other tissues See more
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Genomic context

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See Zfp677 in Genome Data Viewer
Location:
17 A3.2; 17 11.4 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (21603972..21619527)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (21383707..21399265)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene vomeronasal 1 receptor, pseudogene 150 Neighboring gene STARR-positive B cell enhancer ABC_E7494 Neighboring gene zinc finger protein 677 pseudogene Neighboring gene crumbs homolog 1 pseudogene Neighboring gene zinc finger protein 54 Neighboring gene STARR-seq mESC enhancer starr_42007 Neighboring gene STARR-positive B cell enhancer ABC_E9941 Neighboring gene STARR-positive B cell enhancer ABC_E8655 Neighboring gene zinc finger protein 51

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  2. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  3. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  4. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
KRAB-zinc finger protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172486.2 → NP_766074.2  KRAB-zinc finger protein

    See identical proteins and their annotated locations for NP_766074.2

    Status: VALIDATED

    Source sequence(s)
    AI505073, AK043955, BB641850
    Consensus CDS
    CCDS28439.1
    UniProtKB/TrEMBL
    Q6PEP4
    Related
    ENSMUSP00000052667.5, ENSMUST00000056107.11
    Conserved Domains (3) summary
    COG5048
    Location:183 → 600
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:271 → 291
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:12 → 52
    KRAB; KRAB box

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    21603972..21619527
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030249620.2 → XP_030105480.1  KRAB-zinc finger protein isoform X2

    UniProtKB/TrEMBL
    Q6PEP4
    Conserved Domains (3) summary
    COG5048
    Location:183 → 600
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:271 → 291
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:12 → 52
    KRAB; KRAB box

  2. XM_030249619.2 → XP_030105479.1  KRAB-zinc finger protein isoform X1

    UniProtKB/TrEMBL
    Q6PEP4
    Related
    ENSMUSP00000125295.2, ENSMUST00000162659.2
    Conserved Domains (3) summary
    COG5048
    Location:183 → 600
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:271 → 291
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:12 → 52
    KRAB; KRAB box
Nucleotide Protein Strain
Heading Accession and Version

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