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Dock10 dedicator of cytokinesis 10 [ Mus musculus (house mouse) ]

Gene ID: 210293, updated on 21-Apr-2024

Summary

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Official Symbol
Dock10provided by MGI
Official Full Name
dedicator of cytokinesis 10provided by MGI
Primary source
MGI:MGI:2146320
See related
Ensembl:ENSMUSG00000038608 AllianceGenome:MGI:2146320
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Jr4; Jr5; ZIZ3; Zizimin3; mKIAA0694; 9330153B10Rik; A630054M16Rik
Summary
Enables guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in several processes, including dendritic spine morphogenesis; marginal zone B cell differentiation; and positive regulation of GTPase activity. Located in dendritic spine. Is expressed in several structures, including central nervous system; endocrine gland; retina; thymus primordium; and trigeminal nerve. Orthologous to human DOCK10 (dedicator of cytokinesis 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen adult (RPKM 3.8), frontal lobe adult (RPKM 3.8) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 C5; 1 41.41 cM
Exon count:
61
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (80478785..80736482, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (80501068..80758765, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_01459 Neighboring gene STARR-seq mESC enhancer starr_01460 Neighboring gene STARR-positive B cell enhancer mm9_chr1:80415486-80415786 Neighboring gene RIKEN cDNA 1700016L21 gene Neighboring gene GLE1 RNA export mediator pseudogene Neighboring gene predicted gene, 38673 Neighboring gene STARR-seq mESC enhancer starr_01461 Neighboring gene STARR-positive B cell enhancer ABC_E10018 Neighboring gene STARR-positive B cell enhancer mm9_chr1:80743907-80744208 Neighboring gene STARR-seq mESC enhancer starr_01462 Neighboring gene STARR-seq mESC enhancer starr_01463 Neighboring gene neuronal tyrosine-phophorylated phosphoinositide 3-kinase adaptor 2 Neighboring gene STARR-seq mESC enhancer starr_01464 Neighboring gene STARR-seq mESC enhancer starr_01465 Neighboring gene STARR-seq mESC enhancer starr_01466 Neighboring gene R3H domain containing 2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The role of DOCK10 in the regulation of the transcriptome and aging. Ruiz-Lafuente N, et al. Heliyon, 2019 Mar. PMID 30963125, Free PMC Article
  2. Dock10 Regulates Cardiac Function under Neurohormonal Stress. Segal L, et al. Int J Mol Sci, 2022 Aug 25. PMID 36077014, Free PMC Article
  3. Deletion of Dock10 in B Cells Results in Normal Development but a Mild Deficiency upon In Vivo and In Vitro Stimulations. Gerasimčik N, et al. Front Immunol, 2017. PMID 28507547, Free PMC Article
  4. Human and mouse DOCK10 splicing isoforms with alternative first coding exon usage are differentially expressed in T and B lymphocytes. Alcaraz-García MJ, et al. Hum Immunol, 2011 Jul. PMID 21514340
  5. Roles of the DOCK-D family proteins in a mouse model of neuroinflammation. Namekata K, et al. J Biol Chem, 2020 May 8. PMID 32241915, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structural basis for the dual GTPase specificity of the DOCK10 guanine nucleotide exchange factor.
    Title: Structural basis for the dual GTPase specificity of the DOCK10 guanine nucleotide exchange factor.
  2. Dock10 Regulates Cardiac Function under Neurohormonal Stress.
    Title: Dock10 Regulates Cardiac Function under Neurohormonal Stress.
  3. Dock10 negatively regulates membrane CD23 expression; negative regulation of CD23 expression by Dock10 could play a role in B cell maturation and function
    Title: Dock10 regulates CD23 expression and sustains B-cell lymphopoiesis in secondary lymphoid tissue.
  4. DOCK10 function in dendritic spine morphogenesis is mediated mainly by Cdc42 and its downstream effectors N-WASP and PAK3, although DOCK10 is also able to activate Rac1.
    Title: The RhoGEF DOCK10 is essential for dendritic spine morphogenesis.
  5. T cells and B cells exhibited inverse expression patterns of the DOCK10 isoforms
    Title: Human and mouse DOCK10 splicing isoforms with alternative first coding exon usage are differentially expressed in T and B lymphocytes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC183664

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in B cell homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dendritic spine morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dendritic spine morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in marginal zone B cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of postsynapse assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of postsynapse assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in dendritic spine IDA
Inferred from Direct Assay
more info
 PubMed 
located_in glutamatergic synapse IC
Inferred by Curator
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynapse IEP
Inferred from Expression Pattern
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dedicator of cytokinesis protein 10
Names
zizimin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285927.2 → NP_001272856.1  dedicator of cytokinesis protein 10 isoform 2

    See identical proteins and their annotated locations for NP_001272856.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2, alternatively referred to as DOCK10.2) contains an alternate first exon and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC124672, AC132387
    Consensus CDS
    CCDS78626.1
    UniProtKB/TrEMBL
    B2RWY0
    Related
    ENSMUSP00000140085.2, ENSMUST00000187774.7
    Conserved Domains (5) summary
    cd08697
    Location:659 → 848
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11699
    Location:1684 → 2129
    DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10
    cd13267
    Location:170 → 290
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam00169
    Location:170 → 277
    PH; PH domain
    pfam11878
    Location:54 → 141
    DUF3398; Domain of unknown function (DUF3398)

  2. NM_001406554.1 → NP_001393483.1  dedicator of cytokinesis protein 10 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC124672, AC132387

  3. NM_001406555.1 → NP_001393484.1  dedicator of cytokinesis protein 10 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC124672, AC132387
    UniProtKB/TrEMBL
    A0A087WRP5
    Related
    ENSMUSP00000140719.2, ENSMUST00000190983.7

  4. NM_175291.5 → NP_780500.2  dedicator of cytokinesis protein 10 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, alternatively referred to as DOCK10.1) encodes the longer isoform (1).
    Source sequence(s)
    AC124672, AC132387
    Consensus CDS
    CCDS48297.1
    UniProtKB/Swiss-Prot
    A0A087WQ86, E9QM99, F1AHI9, Q8BZN6
    UniProtKB/TrEMBL
    B2RWY0
    Related
    ENSMUSP00000077099.6, ENSMUST00000077946.12
    Conserved Domains (5) summary
    cd08697
    Location:671 → 860
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11699
    Location:1696 → 2141
    DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10
    cd13267
    Location:182 → 302
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam00169
    Location:182 → 289
    PH; PH domain
    pfam11878
    Location:66 → 153
    DUF3398; Domain of unknown function (DUF3398)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    80478785..80736482 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252604.2 → XP_030108464.1  dedicator of cytokinesis protein 10 isoform X20

    UniProtKB/TrEMBL
    B2RWY0
    Conserved Domains (4) summary
    cd08697
    Location:761 → 950
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd13267
    Location:272 → 392
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam11878
    Location:135 → 245
    DUF3398; Domain of unknown function (DUF3398)
    cl06123
    Location:1786 → 2198
    DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins

  2. XM_036163169.1 → XP_036019062.1  dedicator of cytokinesis protein 10 isoform X19

    UniProtKB/TrEMBL
    B2RWY0
    Conserved Domains (4) summary
    cd08697
    Location:761 → 950
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd13267
    Location:272 → 392
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam11878
    Location:135 → 245
    DUF3398; Domain of unknown function (DUF3398)
    cl06123
    Location:1786 → 2198
    DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins

  3. XM_006496475.5 → XP_006496538.3  dedicator of cytokinesis protein 10 isoform X18

    UniProtKB/TrEMBL
    B2RWY0
    Conserved Domains (4) summary
    cd08697
    Location:761 → 950
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd13267
    Location:272 → 392
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam11878
    Location:135 → 245
    DUF3398; Domain of unknown function (DUF3398)
    cl06123
    Location:1786 → 2200
    DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins

  4. XM_006496470.5 → XP_006496533.3  dedicator of cytokinesis protein 10 isoform X12

    UniProtKB/TrEMBL
    B2RWY0
    Conserved Domains (4) summary
    cd08697
    Location:761 → 950
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11699
    Location:1786 → 2233
    DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10
    cd13267
    Location:272 → 392
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam11878
    Location:135 → 245
    DUF3398; Domain of unknown function (DUF3398)

  5. XM_006496469.5 → XP_006496532.3  dedicator of cytokinesis protein 10 isoform X10

    UniProtKB/TrEMBL
    B2RWY0
    Conserved Domains (4) summary
    cd08697
    Location:761 → 950
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11699
    Location:1786 → 2233
    DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10
    cd13267
    Location:272 → 392
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam11878
    Location:135 → 245
    DUF3398; Domain of unknown function (DUF3398)

  6. XM_030252603.2 → XP_030108463.1  dedicator of cytokinesis protein 10 isoform X13

    UniProtKB/TrEMBL
    B2RWY0
    Conserved Domains (4) summary
    cd08697
    Location:761 → 950
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11699
    Location:1777 → 2222
    DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10
    cd13267
    Location:272 → 392
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam11878
    Location:135 → 245
    DUF3398; Domain of unknown function (DUF3398)

  7. XM_017319527.3 → XP_017175016.2  dedicator of cytokinesis protein 10 isoform X11

    UniProtKB/TrEMBL
    B2RWY0
    Conserved Domains (4) summary
    cd08697
    Location:761 → 950
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11699
    Location:1786 → 2231
    DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10
    cd13267
    Location:272 → 392
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam11878
    Location:135 → 245
    DUF3398; Domain of unknown function (DUF3398)

  8. XM_017319532.3 → XP_017175021.2  dedicator of cytokinesis protein 10 isoform X16

    UniProtKB/TrEMBL
    B2RWY0
    Conserved Domains (4) summary
    cd08697
    Location:761 → 950
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11699
    Location:1786 → 2233
    DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10
    cd13267
    Location:272 → 392
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam11878
    Location:135 → 245
    DUF3398; Domain of unknown function (DUF3398)

  9. XM_030252594.2 → XP_030108454.1  dedicator of cytokinesis protein 10 isoform X5

    UniProtKB/TrEMBL
    B2RWY0
    Conserved Domains (4) summary
    cd08697
    Location:761 → 950
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11699
    Location:1777 → 2222
    DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10
    cd13267
    Location:272 → 392
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam11878
    Location:135 → 245
    DUF3398; Domain of unknown function (DUF3398)

  10. XM_006496466.5 → XP_006496529.3  dedicator of cytokinesis protein 10 isoform X4

    UniProtKB/TrEMBL
    B2RWY0
    Conserved Domains (4) summary
    cd08697
    Location:761 → 950
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11699
    Location:1777 → 2224
    DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10
    cd13267
    Location:272 → 392
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam11878
    Location:135 → 245
    DUF3398; Domain of unknown function (DUF3398)

  11. XM_006496468.5 → XP_006496531.3  dedicator of cytokinesis protein 10 isoform X7

    UniProtKB/TrEMBL
    B2RWY0
    Conserved Domains (4) summary
    cd08697
    Location:761 → 950
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd13267
    Location:272 → 392
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam11878
    Location:135 → 245
    DUF3398; Domain of unknown function (DUF3398)
    cl06123
    Location:1786 → 2198
    DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins

  12. XM_006496467.5 → XP_006496530.3  dedicator of cytokinesis protein 10 isoform X6

    UniProtKB/TrEMBL
    B2RWY0
    Conserved Domains (4) summary
    cd08697
    Location:761 → 950
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd13267
    Location:272 → 392
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam11878
    Location:135 → 245
    DUF3398; Domain of unknown function (DUF3398)
    cl06123
    Location:1786 → 2200
    DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins

  13. XM_006496465.5 → XP_006496528.3  dedicator of cytokinesis protein 10 isoform X3

    UniProtKB/TrEMBL
    B2RWY0
    Conserved Domains (4) summary
    cd08697
    Location:761 → 950
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11699
    Location:1786 → 2231
    DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10
    cd13267
    Location:272 → 392
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam11878
    Location:135 → 245
    DUF3398; Domain of unknown function (DUF3398)

  14. XM_036163168.1 → XP_036019061.1  dedicator of cytokinesis protein 10 isoform X17

    UniProtKB/TrEMBL
    B2RWY0
    Conserved Domains (4) summary
    cd08697
    Location:761 → 950
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11699
    Location:1786 → 2231
    DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10
    cd13267
    Location:272 → 392
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam11878
    Location:135 → 245
    DUF3398; Domain of unknown function (DUF3398)

  15. XM_006496463.5 → XP_006496526.3  dedicator of cytokinesis protein 10 isoform X1

    UniProtKB/TrEMBL
    B2RWY0
    Conserved Domains (4) summary
    cd08697
    Location:761 → 950
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11699
    Location:1786 → 2233
    DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10
    cd13267
    Location:272 → 392
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam11878
    Location:135 → 245
    DUF3398; Domain of unknown function (DUF3398)

  16. XM_006496464.5 → XP_006496527.2  dedicator of cytokinesis protein 10 isoform X2

    UniProtKB/TrEMBL
    B2RWY0
    Conserved Domains (4) summary
    cd08697
    Location:670 → 859
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11699
    Location:1695 → 2142
    DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10
    cd13267
    Location:181 → 301
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam11878
    Location:44 → 154
    DUF3398; Domain of unknown function (DUF3398)

  17. XM_006496471.5 → XP_006496534.1  dedicator of cytokinesis protein 10 isoform X14

    See identical proteins and their annotated locations for XP_006496534.1

    UniProtKB/TrEMBL
    B2RWY0
    Conserved Domains (4) summary
    cd08697
    Location:659 → 848
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11699
    Location:1684 → 2131
    DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10
    cd13267
    Location:170 → 290
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam11878
    Location:33 → 143
    DUF3398; Domain of unknown function (DUF3398)

  18. XM_036163163.1 → XP_036019056.1  dedicator of cytokinesis protein 10 isoform X9

    UniProtKB/TrEMBL
    B2RWY0
    Conserved Domains (4) summary
    cd08697
    Location:683 → 872
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11699
    Location:1708 → 2155
    DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10
    cd13267
    Location:194 → 314
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam11878
    Location:57 → 167
    DUF3398; Domain of unknown function (DUF3398)

  19. XM_017319519.3 → XP_017175008.1  dedicator of cytokinesis protein 10 isoform X8

    UniProtKB/TrEMBL
    B2RWY0
    Conserved Domains (4) summary
    cd08697
    Location:684 → 873
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11699
    Location:1709 → 2156
    DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10
    cd13267
    Location:195 → 315
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam11878
    Location:58 → 168
    DUF3398; Domain of unknown function (DUF3398)

  20. XM_036163166.1 → XP_036019059.1  dedicator of cytokinesis protein 10 isoform X15

    UniProtKB/TrEMBL
    B2RWY0
    Conserved Domains (4) summary
    cd08697
    Location:658 → 847
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11699
    Location:1683 → 2130
    DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10
    cd13267
    Location:169 → 289
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam11878
    Location:32 → 142
    DUF3398; Domain of unknown function (DUF3398)

  21. XM_011238683.4 → XP_011236985.1  dedicator of cytokinesis protein 10 isoform X23

    UniProtKB/TrEMBL
    A0A0R4J2B7
    Related
    ENSMUSP00000139567.2, ENSMUST00000190595.7
    Conserved Domains (2) summary
    cd08697
    Location:156 → 345
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11699
    Location:1181 → 1628
    DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10

RNA

  1. XR_373539.5 RNA Sequence

  2. XR_003954321.2 RNA Sequence

  3. XR_003954322.1 RNA Sequence

  4. XR_003954323.1 RNA Sequence

  5. XR_001783679.3 RNA Sequence

  6. XR_003954325.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BZN6.4 GenPept UniProtKB/Swiss-Prot:Q8BZN6

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