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Zkscan2 zinc finger with KRAB and SCAN domains 2 [ Mus musculus (house mouse) ]

Gene ID: 210162, updated on 5-Mar-2024

Summary

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Official Symbol
Zkscan2provided by MGI
Official Full Name
zinc finger with KRAB and SCAN domains 2provided by MGI
Primary source
MGI:MGI:2444060
See related
Ensembl:ENSMUSG00000030757 AllianceGenome:MGI:2444060
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zfp694; 9430065N20Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Is expressed in bladder; female associated reproductive structure; ovary; ureter; and urethra of female. Orthologous to human ZKSCAN2 (zinc finger with KRAB and SCAN domains 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 4.7), whole brain E14.5 (RPKM 4.1) and 8 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 F3; 7 67.42 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (123074607..123105685, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (123475384..123505077, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:130521438-130521621 Neighboring gene leucine carboxyl methyltransferase 1 Neighboring gene aquaporin 8 Neighboring gene predicted gene, 53370 Neighboring gene predicted gene, 53371

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. C2H2 Zinc Finger Proteins: The Largest but Poorly Explored Family of Higher Eukaryotic Transcription Factors. Fedotova AA, et al. Acta Naturae, 2017 Apr-Jun. PMID 28740726, Free PMC Article
  2. Evolution of C2H2-zinc finger genes revisited. Thomas JH, et al. BMC Evol Biol, 2009 Mar 4. PMID 19261184, Free PMC Article
  3. A Dynamic Splicing Program Ensures Proper Synaptic Connections in the Developing Cerebellum. Farini D, et al. Cell Rep, 2020 Jun 2. PMID 32492419
  4. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein with KRAB and SCAN domains 2
Names
zinc finger protein 694

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081329.2 → NP_001074798.1  zinc finger protein with KRAB and SCAN domains 2

    See identical proteins and their annotated locations for NP_001074798.1

    Status: VALIDATED

    Source sequence(s)
    AC117184, AK034954, AK080486
    Consensus CDS
    CCDS40119.1
    UniProtKB/TrEMBL
    G3X952
    Related
    ENSMUSP00000041821.8, ENSMUST00000042470.14
    Conserved Domains (9) summary
    smart00431
    Location:42 → 148
    SCAN; leucine rich region
    smart00349
    Location:241 → 282
    KRAB; krueppel associated box
    COG5048
    Location:766 → 915
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:798 → 818
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:768 → 790
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:42 → 129
    SCAN; SCAN domain
    pfam13465
    Location:782 → 806
    zf-H2C2_2; Zinc-finger double domain
    pfam13837
    Location:334 → 415
    Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain
    pfam14510
    Location:466 → 505
    ABC_trans_N; ABC-transporter extracellular N-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    123074607..123105685 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507551.4 → XP_006507614.1  zinc finger protein with KRAB and SCAN domains 2 isoform X2

    Conserved Domains (3) summary
    COG5048
    Location:313 → 462
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:345 → 365
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13837
    Location:37 → 122
    Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain

  2. XM_036152868.1 → XP_036008761.1  zinc finger protein with KRAB and SCAN domains 2 isoform X1

    Conserved Domains (3) summary
    pfam13837
    Location:490 → 571
    Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain
    cl02581
    Location:241 → 282
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    cl02605
    Location:42 → 148
    SCAN; SCAN oligomerization domain

RNA

  1. XR_378227.5 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_175435.2: Suppressed sequence

    Description
    NM_175435.2: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
Nucleotide Protein Strain
Heading Accession and Version

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