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Zfp180 zinc finger protein 180 [ Mus musculus (house mouse) ]

Gene ID: 210135, updated on 5-Mar-2024

Summary

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Official Symbol
Zfp180provided by MGI
Official Full Name
zinc finger protein 180provided by MGI
Primary source
MGI:MGI:1923701
See related
Ensembl:ENSMUSG00000057101 AllianceGenome:MGI:1923701
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HHZ168; D130011P11; 2310040I01Rik
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Is expressed in several structures, including central nervous system; eye; genitourinary system; limb; and liver. Orthologous to human ZNF180 (zinc finger protein 180). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 11.9), whole brain E14.5 (RPKM 10.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Zfp180 in Genome Data Viewer
Location:
7 A3; 7 10.27 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (23781303..23807134)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (24081877..24107709)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene prothymosin alpha, pseudogene 1 Neighboring gene predicted gene, 36694 Neighboring gene STARR-seq mESC enhancer starr_18250 Neighboring gene zinc finger protein 112 Neighboring gene STARR-positive B cell enhancer ABC_E2817 Neighboring gene zinc finger protein 235

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. Shannon M, et al. Genome Res, 2003 Jun. PMID 12743021, Free PMC Article
  2. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  3. An atlas of combinatorial transcriptional regulation in mouse and man. Ravasi T, et al. Cell, 2010 Mar 5. PMID 20211142, Free PMC Article
  4. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 180

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045486.2 → NP_001038951.1  zinc finger protein 180 isoform a

    See identical proteins and their annotated locations for NP_001038951.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC121271, AK141922, BC066115
    Consensus CDS
    CCDS39823.1
    UniProtKB/TrEMBL
    Q6NZI9
    Related
    ENSMUSP00000064611.4, ENSMUST00000068975.6
    Conserved Domains (4) summary
    COG5048
    Location:297 → 650
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:488 → 508
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:318 → 340
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:528 → 553
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001289634.1 → NP_001276563.1  zinc finger protein 180 isoform b

    See identical proteins and their annotated locations for NP_001276563.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an additional internal exon, and it thus differs in its 5' UTR and initiates translation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode isoform b.
    Source sequence(s)
    AC121271, AK141922, BC066115, BQ771416
    UniProtKB/TrEMBL
    Q6NZI9
    Conserved Domains (4) summary
    COG5048
    Location:273 → 626
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:464 → 484
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:294 → 316
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:504 → 529
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001289637.1 → NP_001276566.1  zinc finger protein 180 isoform b

    See identical proteins and their annotated locations for NP_001276566.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an internal exon, and it thus differs in its 5' UTR and initiates translation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode isoform b.
    Source sequence(s)
    AC121271, AK141922, BC066115, CF736119
    UniProtKB/TrEMBL
    Q6NZI9
    Conserved Domains (4) summary
    COG5048
    Location:273 → 626
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:464 → 484
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:294 → 316
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:504 → 529
    zf-H2C2_2; Zinc-finger double domain

  4. NM_001289640.1 → NP_001276569.1  zinc finger protein 180 isoform c

    See identical proteins and their annotated locations for NP_001276569.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in an internal exon, and it thus differs in its 5' UTR and initiates translation from an alternate start codon, compared to variant 1. The encoded isoform (c) has a distinct and shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AC121271, AK141922, BC066115
    UniProtKB/TrEMBL
    Q6P407
    Conserved Domains (3) summary
    COG5048
    Location:263 → 616
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:454 → 474
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:494 → 519
    zf-H2C2_2; Zinc-finger double domain

  5. NM_001289641.1 → NP_001276570.1  zinc finger protein 180 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in an internal exon, and it thus differs in its 5' UTR and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (d) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AC121271, AK141922, BC066115
    UniProtKB/TrEMBL
    Q6NZI9
    Conserved Domains (3) summary
    COG5048
    Location:237 → 590
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:428 → 448
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:468 → 493
    zf-H2C2_2; Zinc-finger double domain

  6. NM_172483.2 → NP_766071.1  zinc finger protein 180 isoform e

    See identical proteins and their annotated locations for NP_766071.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks two internal exons, and it thus differs in its 5' UTR and initiates translation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (e) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AC121271, AK083802
    UniProtKB/TrEMBL
    Q8BJI2
    Conserved Domains (3) summary
    COG5048
    Location:148 → 410
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:313 → 333
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:437 → 462
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    23781303..23807134
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242320.2 → XP_030098180.1  zinc finger protein 180 isoform X1

    UniProtKB/TrEMBL
    Q8BJI2
    Conserved Domains (3) summary
    COG5048
    Location:148 → 410
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:313 → 333
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:437 → 462
    zf-H2C2_2; Zinc-finger double domain

  2. XM_036152867.1 → XP_036008760.1  zinc finger protein 180 isoform X1

    UniProtKB/TrEMBL
    Q8BJI2
    Conserved Domains (3) summary
    COG5048
    Location:148 → 410
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:313 → 333
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:437 → 462
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version

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