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Tent4a terminal nucleotidyltransferase 4A [ Mus musculus (house mouse) ]

Gene ID: 210106, updated on 11-Apr-2024

Summary

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Official Symbol
Tent4aprovided by MGI
Official Full Name
terminal nucleotidyltransferase 4Aprovided by MGI
Primary source
MGI:MGI:2682295
See related
Ensembl:ENSMUSG00000034575 AllianceGenome:MGI:2682295
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
POLK; Pols; TRF4; LAK-1; Papd7; TRF4-1
Summary
Predicted to enable guanylyltransferase activity and polynucleotide adenylyltransferase activity. Predicted to be involved in RNA 3' uridylation; regulation of mRNA stability; and response to xenobiotic stimulus. Predicted to act upstream of or within mRNA processing. Predicted to be located in Golgi apparatus; nuclear membrane; and nucleoplasm. Predicted to be part of TRAMP complex. Predicted to be active in nucleolus. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and musculoskeletal system. Orthologous to human TENT4A (terminal nucleotidyltransferase 4A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 10.5), adrenal adult (RPKM 9.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tent4a in Genome Data Viewer
Location:
13 B3; 13 35.55 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (69646071..69682710, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (69497952..69534236, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35444 Neighboring gene STARR-seq mESC enhancer starr_34935 Neighboring gene predicted gene, 35514 Neighboring gene STARR-seq mESC enhancer starr_34936 Neighboring gene STARR-seq mESC enhancer starr_34937 Neighboring gene RIKEN cDNA A930018O16 gene Neighboring gene RIKEN cDNA A530095I07 gene Neighboring gene RAB geranylgeranyl transferase, b subunit pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A digenic cause of cleft lip in A-strain mice and definition of candidate genes for the two loci. Juriloff DM, et al. Birth Defects Res A Clin Mol Teratol, 2004 Aug. PMID 15329828
  2. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
  3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC69673

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables guanylyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables poly(A) RNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA 3' uridylation ISO
Inferred from Sequence Orthology
more info
  
involved_in RNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of nuclear-transcribed mRNA poly(A) tail shortening ISO
Inferred from Sequence Orthology
more info
  
involved_in polyadenylation-dependent ncRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of 3'-UTR-mediated mRNA stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
part_of TRAMP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
terminal nucleotidyltransferase 4A
Names
DNA polymerase sigma
PAP associated domain containing 7
PAP-associated domain-containing protein 7
TRAMP-like complex polyadenylate polymerase
non-canonical poly(A) RNA polymerase PAPD7
polymerase (DNA directed) sigma
terminal guanylyltransferase
NP_001162602.2
NP_941002.3
XP_006517250.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001169131.2 → NP_001162602.2  terminal nucleotidyltransferase 4A isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC122484

  2. NM_198600.3 → NP_941002.3  terminal nucleotidyltransferase 4A isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC122484
    Consensus CDS
    CCDS26622.1
    UniProtKB/TrEMBL
    A0A0G2JDV2
    Related
    ENSMUSP00000142516.2, ENSMUST00000198607.5

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    69646071..69682710 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517187.2 → XP_006517250.1  terminal nucleotidyltransferase 4A isoform X1

    Conserved Domains (1) summary
    COG5260
    Location:233 → 538
    TRF4; DNA polymerase sigma [Replication, recombination and repair]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PB75.2 GenPept UniProtKB/Swiss-Prot:Q6PB75

Gene LinkOut

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