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Slc38a5 solute carrier family 38, member 5 [ Mus musculus (house mouse) ]

Gene ID: 209837, updated on 21-Apr-2024

Summary

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Official Symbol
Slc38a5provided by MGI
Official Full Name
solute carrier family 38, member 5provided by MGI
Primary source
MGI:MGI:2148066
See related
Ensembl:ENSMUSG00000031170 AllianceGenome:MGI:2148066
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SN2; JM24; E330031E14
Summary
Predicted to enable amino acid transmembrane transporter activity. Predicted to be involved in amino acid transport. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including central nervous system; foregut-midgut junction; liver lobe; metanephros; and pericardium. Orthologous to human SLC38A5 (solute carrier family 38 member 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in genital fat pad adult (RPKM 1166.3) and ovary adult (RPKM 77.4) See more
Orthologs
human all
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Genomic context

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Location:
X A1.1; X 3.74 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (8137620..8146418)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (8271381..8280179)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_46693 Neighboring gene FtsJ RNA 2'-O-methyltransferase 1 Neighboring gene STARR-seq mESC enhancer starr_46694 Neighboring gene predicted gene, 54078 Neighboring gene SSX member B10 Neighboring gene SSX member B9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Amino Acid Transporter Slc38a5 Controls Glucagon Receptor Inhibition-Induced Pancreatic α Cell Hyperplasia in Mice. Kim J, et al. Cell Metab, 2017 Jun 6. PMID 28591637, Free PMC Article
  2. Expression and function of system N glutamine transporters (SN1/SN2 or SNAT3/SNAT5) in retinal ganglion cells. Umapathy NS, et al. Invest Ophthalmol Vis Sci, 2008 Nov. PMID 18689705, Free PMC Article
  3. Amino acid transporter SLC38A5 regulates developmental and pathological retinal angiogenesis. Wang Z, et al. Elife, 2022 Dec 1. PMID 36454214, Free PMC Article
  4. Expression and function of glutamine transporters SN1 (SNAT3) and SN2 (SNAT5) in retinal Müller cells. Umapathy NS, et al. Invest Ophthalmol Vis Sci, 2005 Nov. PMID 16249471
  5. Neurodevelopmental consequences of Smn depletion in a mouse model of spinal muscular atrophy. Liu H, et al. J Neurosci Res, 2010 Jan. PMID 19642194

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Impairment of serine transport across the blood-brain barrier by deletion of Slc38a5 causes developmental delay and motor dysfunction.
    Title: Impairment of serine transport across the blood-brain barrier by deletion of Slc38a5 causes developmental delay and motor dysfunction.
  2. Amino acid transporter SLC38A5 is a tumor promoter and a novel therapeutic target for pancreatic cancer.
    Title: Amino acid transporter SLC38A5 is a tumor promoter and a novel therapeutic target for pancreatic cancer.
  3. These results show that Slc38a5 is a key component of the feedback circuit between glucagon receptor signaling in the liver and amino-acid-dependent regulation of pancreatic alpha cell mass in mice.
    Title: Amino Acid Transporter Slc38a5 Controls Glucagon Receptor Inhibition-Induced Pancreatic α Cell Hyperplasia in Mice.
  4. ISH and IF revealed SN1 and SN2 expression in the ganglion, inner nuclear, and photoreceptor cell layers.
    Title: Expression and function of system N glutamine transporters (SN1/SN2 or SNAT3/SNAT5) in retinal ganglion cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 
  • Endonuclease-mediated (2)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-asparagine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables L-glutamine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-glutamine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables L-glutamine, sodium:proton antiporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables L-glutamine, sodium:proton antiporter activity ISO
Inferred from Sequence Orthology
more info
  
enables L-histidine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables L-serine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables alanine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables amino acid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables glycine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables neutral L-amino acid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables neutral amino acid, sodium:proton antiporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in L-alanine transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in L-glutamine import across plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in L-glutamine import across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in L-histidine transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-histidine transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in L-serine import across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in L-serine transport ISO
Inferred from Sequence Orthology
more info
  
involved_in amino acid export across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in amino acid import across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in asparagine transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in glutamine transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glutamine transport ISO
Inferred from Sequence Orthology
more info
  
involved_in glycine transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycine transport ISO
Inferred from Sequence Orthology
more info
  
involved_in neutral amino acid transport ISO
Inferred from Sequence Orthology
more info
  
involved_in serine transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in serine transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
sodium-coupled neutral amino acid transporter 5
Names
system N transporter 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172479.3 → NP_766067.2  sodium-coupled neutral amino acid transporter 5

    See identical proteins and their annotated locations for NP_766067.2

    Status: VALIDATED

    Source sequence(s)
    AK054485, AK158125, AL805902, BX523289
    Consensus CDS
    CCDS52990.1
    UniProtKB/Swiss-Prot
    Q3TZ39, Q3U1J0, Q8BJZ6, Q8BW30
    Related
    ENSMUSP00000033512.5, ENSMUST00000033512.11
    Conserved Domains (2) summary
    COG0814
    Location:56 → 469
    SdaC; Amino acid permease [Amino acid transport and metabolism]
    cl00456
    Location:56 → 466
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    8137620..8146418
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3U1J0.1 GenPept UniProtKB/Swiss-Prot:Q3U1J0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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