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Tbc1d25 TBC1 domain family, member 25 [ Mus musculus (house mouse) ]

Gene ID: 209815, updated on 21-Apr-2024

Summary

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Official Symbol
Tbc1d25provided by MGI
Official Full Name
TBC1 domain family, member 25provided by MGI
Primary source
MGI:MGI:2444862
See related
Ensembl:ENSMUSG00000039201 AllianceGenome:MGI:2444862
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Oatl1; DXHXS7927e; 6330576A08Rik
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in activation of GTPase activity; intracellular protein transport; and regulation of autophagosome maturation. Predicted to act upstream of or within autophagy. Predicted to be located in cytoplasmic vesicle. Predicted to be active in autophagosome. Orthologous to human TBC1D25 (TBC1 domain family member 25). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 10.2), whole brain E14.5 (RPKM 8.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
X A1.1; X 3.69 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (8020709..8042420, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (8154470..8176181, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7686 Neighboring gene WD repeat domain 13 Neighboring gene RNA binding motif (RNP1, RRM) protein 3 Neighboring gene RNA binding motif protein 3, opposite strand Neighboring gene STARR-seq mESC enhancer starr_46689 Neighboring gene STARR-seq mESC enhancer starr_46690 Neighboring gene EBP cholestenol delta-isomerase Neighboring gene porcupine O-acyltransferase Neighboring gene predicted gene, 33135

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TBC1D25 alleviates nonalcoholic steatohepatitis by inhibiting abnormal lipid accumulation and inflammation. Wu A, et al. J Cell Physiol, 2023 Feb. PMID 36710714
  2. TBC1Domain Family Member 25 deficiency aggravates cerebral ischemia-reperfusion injury via TAK1-JNK/p38 pathway. Zhang Z, et al. J Neurochem, 2022 Feb. PMID 34837397
  3. TBC1D25 Regulates Cardiac Remodeling Through TAK1 Signaling Pathway. Guo S, et al. Int J Biol Sci, 2020. PMID 32210723, Free PMC Article
  4. OATL1, a novel autophagosome-resident Rab33B-GAP, regulates autophagosomal maturation. Itoh T, et al. J Cell Biol, 2011 Mar 7. PMID 21383079, Free PMC Article
  5. Mutations in a delta 8-delta 7 sterol isomerase in the tattered mouse and X-linked dominant chondrodysplasia punctata. jderry@immunex.com. Derry JM, et al. Nat Genet, 1999 Jul. PMID 10391218

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TBC1D25 alleviates nonalcoholic steatohepatitis by inhibiting abnormal lipid accumulation and inflammation.
    Title: TBC1D25 alleviates nonalcoholic steatohepatitis by inhibiting abnormal lipid accumulation and inflammation.
  2. TBC1D25 Regulates Cardiac Remodeling Through TAK1 Signaling Pathway.
    Title: TBC1D25 Regulates Cardiac Remodeling Through TAK1 Signaling Pathway.
  3. OATL1 has a role in autophagy.
    Title: OATL1, a novel autophagosome-resident Rab33B-GAP, regulates autophagosomal maturation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
involved_in activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of autophagosome maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of autophagosome maturation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in autophagosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in autophagosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
TBC1 domain family member 25
Names
ornithine aminotransferase-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166437.1 → NP_001159909.1  TBC1 domain family member 25 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK078145, AK207073, BC128565
    Consensus CDS
    CCDS52989.1
    UniProtKB/TrEMBL
    A2VCT6, E9PWX7
    Related
    ENSMUSP00000131652.2, ENSMUST00000172020.8
    Conserved Domains (1) summary
    smart00164
    Location:260 → 489
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  2. NM_172478.4 → NP_766066.3  TBC1 domain family member 25 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL663032
    Consensus CDS
    CCDS29988.1
    UniProtKB/TrEMBL
    A0A6I8MX15, A2BD48
    Related
    ENSMUSP00000159357.2, ENSMUST00000239441.2
    Conserved Domains (1) summary
    smart00164
    Location:225 → 454
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    8020709..8042420 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251294.1 → XP_030107154.1  TBC1 domain family member 25 isoform X1

    UniProtKB/TrEMBL
    S4R2S6
    Related
    ENSMUSP00000138768.2, ENSMUST00000143984.2
    Conserved Domains (1) summary
    smart00164
    Location:97 → 326
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1A5B6.1 GenPept UniProtKB/Swiss-Prot:A1A5B6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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