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Syt3 synaptotagmin III [ Mus musculus (house mouse) ]

Gene ID: 20981, updated on 11-Apr-2024

Summary

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Official Symbol
Syt3provided by MGI
Official Full Name
synaptotagmin IIIprovided by MGI
Primary source
MGI:MGI:99665
See related
Ensembl:ENSMUSG00000030731 AllianceGenome:MGI:99665
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
sytIII
Summary
Enables calcium-dependent phospholipid binding activity; protein heterodimerization activity; and protein homodimerization activity. Predicted to be involved in several processes, including positive regulation of dendrite extension; regulation of dopamine secretion; and regulation of vesicle-mediated transport. Predicted to act upstream of or within cell differentiation and exocytosis. Predicted to be located in endosome. Predicted to be active in exocytic vesicle and plasma membrane. Is expressed in several structures, including eye; genitourinary system; heart; nervous system; and respiratory system. Orthologous to human SYT3 (synaptotagmin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 17.0), cortex adult (RPKM 9.0) and 14 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 B3; 7 28.83 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44032197..44049454)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (44382773..44400030)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene SH3 and multiple ankyrin repeat domains 1 Neighboring gene RIKEN cDNA 1700008O03 gene Neighboring gene STARR-seq mESC enhancer starr_18792 Neighboring gene predicted gene, 39001 Neighboring gene STARR-positive B cell enhancer ABC_E4924 Neighboring gene STARR-seq mESC enhancer starr_18797 Neighboring gene predicted gene, 39002 Neighboring gene leucine rich repeat containing 4B Neighboring gene predicted gene, 39003

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Fast resupply of synaptic vesicles requires synaptotagmin-3. Weingarten DJ, et al. Nature, 2022 Nov. PMID 36261524
  2. Functional diversity of C2 domains of synaptotagmin family. Mutational analysis of inositol high polyphosphate binding domain. Fukuda M, et al. J Biol Chem, 1995 Nov 3. PMID 7592870
  3. Synaptotagmin-3 interactions with GluA2 mediate brain damage and impair functional recovery in stroke. Lu H, et al. Cell Rep, 2023 Mar 28. PMID 36892998
  4. Synaptotagmin 3 deficiency in T cells impairs recycling of the chemokine receptor CXCR4 and thereby inhibits CXCL12 chemokine-induced migration. Masztalerz A, et al. J Cell Sci, 2007 Jan 15. PMID 17179206
  5. Genomic structures of synaptotagmin II protein: comparison of exon-intron organization of the synaptotagmin gene family. Fukuda M, et al. Biochem Biophys Res Commun, 2000 Apr 13. PMID 10753658

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Synaptotagmin-3 interactions with GluA2 mediate brain damage and impair functional recovery in stroke.
    Title: Synaptotagmin-3 interactions with GluA2 mediate brain damage and impair functional recovery in stroke.
  2. Fast resupply of synaptic vesicles requires synaptotagmin-3.
    Title: Fast resupply of synaptic vesicles requires synaptotagmin-3.
  3. the combined inactivation of all 3 E-Syt genes has no effect on mouse viability or fertility.
    Title: Loss of all 3 Extended Synaptotagmins does not affect normal mouse development, viability or fertility.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SNARE binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent phospholipid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium-dependent phospholipid binding ISO
Inferred from Sequence Orthology
more info
  
enables clathrin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables clathrin binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylserine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylserine binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables syntaxin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in calcium-ion regulated exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within exocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of dendrite extension ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of vesicle fusion ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of calcium ion-dependent exocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to calcium ion ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in exocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynapse IEP
Inferred from Expression Pattern
more info
 PubMed 
is_active_in synaptic membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
synaptotagmin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114116.2 → NP_001107588.1  synaptotagmin-3

    See identical proteins and their annotated locations for NP_001107588.1

    Status: VALIDATED

    Source sequence(s)
    AC152939
    Consensus CDS
    CCDS21205.1
    UniProtKB/Swiss-Prot
    O35681, P97791, Q80WV1
    UniProtKB/TrEMBL
    G3X9Y1
    Related
    ENSMUSP00000114070.2, ENSMUST00000118962.8
    Conserved Domains (2) summary
    cd08385
    Location:297 → 421
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08403
    Location:430 → 564
    C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10

  2. NM_001417323.1 → NP_001404252.1  synaptotagmin-3

    Status: VALIDATED

    Source sequence(s)
    AC152939
    UniProtKB/TrEMBL
    G3X9Y1

  3. NM_001417324.1 → NP_001404253.1  synaptotagmin-3

    Status: VALIDATED

    Source sequence(s)
    AC152939
    UniProtKB/TrEMBL
    G3X9Y1

  4. NM_001417325.1 → NP_001404254.1  synaptotagmin-3

    Status: VALIDATED

    Source sequence(s)
    AC152939
    UniProtKB/TrEMBL
    G3X9Y1
    Related
    ENSMUSP00000112968.2, ENSMUST00000120262.2

  5. NM_001417326.1 → NP_001404255.1  synaptotagmin-3

    Status: VALIDATED

    Source sequence(s)
    AC152939
    UniProtKB/TrEMBL
    G3X9Y1

  6. NM_016663.4 → NP_057872.3  synaptotagmin-3

    See identical proteins and their annotated locations for NP_057872.3

    Status: VALIDATED

    Source sequence(s)
    AC152939
    Consensus CDS
    CCDS21205.1
    UniProtKB/Swiss-Prot
    O35681, P97791, Q80WV1
    UniProtKB/TrEMBL
    G3X9Y1
    Related
    ENSMUSP00000112432.2, ENSMUST00000118831.8
    Conserved Domains (2) summary
    cd08385
    Location:297 → 421
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08403
    Location:430 → 564
    C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    44032197..44049454
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242318.1 → XP_030098178.1  synaptotagmin-3 isoform X1

    UniProtKB/Swiss-Prot
    O35681, P97791, Q80WV1
    UniProtKB/TrEMBL
    G3X9Y1
    Conserved Domains (2) summary
    cd08385
    Location:297 → 421
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08403
    Location:430 → 564
    C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10

  2. XM_036152863.1 → XP_036008756.1  synaptotagmin-3 isoform X1

    UniProtKB/Swiss-Prot
    O35681, P97791, Q80WV1
    UniProtKB/TrEMBL
    G3X9Y1
    Conserved Domains (2) summary
    cd08385
    Location:297 → 421
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08403
    Location:430 → 564
    C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10

  3. XM_017322088.1 → XP_017177577.1  synaptotagmin-3 isoform X1

    UniProtKB/Swiss-Prot
    O35681, P97791, Q80WV1
    UniProtKB/TrEMBL
    G3X9Y1
    Conserved Domains (2) summary
    cd08385
    Location:297 → 421
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08403
    Location:430 → 564
    C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10

  4. XM_017322089.1 → XP_017177578.1  synaptotagmin-3 isoform X1

    UniProtKB/Swiss-Prot
    O35681, P97791, Q80WV1
    UniProtKB/TrEMBL
    G3X9Y1
    Conserved Domains (2) summary
    cd08385
    Location:297 → 421
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08403
    Location:430 → 564
    C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10

  5. XM_030242319.1 → XP_030098179.1  synaptotagmin-3 isoform X1

    UniProtKB/Swiss-Prot
    O35681, P97791, Q80WV1
    UniProtKB/TrEMBL
    G3X9Y1
    Conserved Domains (2) summary
    cd08385
    Location:297 → 421
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08403
    Location:430 → 564
    C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10

  6. XM_036152864.1 → XP_036008757.1  synaptotagmin-3 isoform X1

    UniProtKB/Swiss-Prot
    O35681, P97791, Q80WV1
    UniProtKB/TrEMBL
    G3X9Y1
    Conserved Domains (2) summary
    cd08385
    Location:297 → 421
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08403
    Location:430 → 564
    C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10

  7. XM_017322087.2 → XP_017177576.1  synaptotagmin-3 isoform X1

    UniProtKB/Swiss-Prot
    O35681, P97791, Q80WV1
    UniProtKB/TrEMBL
    G3X9Y1
    Conserved Domains (2) summary
    cd08385
    Location:297 → 421
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08403
    Location:430 → 564
    C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10

  8. XM_030242317.2 → XP_030098177.1  synaptotagmin-3 isoform X1

    UniProtKB/Swiss-Prot
    O35681, P97791, Q80WV1
    UniProtKB/TrEMBL
    G3X9Y1
    Conserved Domains (2) summary
    cd08385
    Location:297 → 421
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08403
    Location:430 → 564
    C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35681.2 GenPept UniProtKB/Swiss-Prot:O35681

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