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Nudcd3 NudC domain containing 3 [ Mus musculus (house mouse) ]

Gene ID: 209586, updated on 3-Apr-2024

Summary

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Official Symbol
Nudcd3provided by MGI
Official Full Name
NudC domain containing 3provided by MGI
Primary source
MGI:MGI:2144158
See related
Ensembl:ENSMUSG00000053838 AllianceGenome:MGI:2144158
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1068
Summary
Predicted to enable unfolded protein binding activity. Predicted to be involved in cilium assembly; protein folding; and protein localization to pericentriolar material. Predicted to be part of cytoplasmic dynein complex. Predicted to be active in cytoplasm. Orthologous to human NUDCD3 (NudC domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cortex adult (RPKM 21.3), frontal lobe adult (RPKM 20.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 A1; 11 3.91 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (6055705..6150190, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (6105691..6201619, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6947 Neighboring gene YKT6 v-SNARE homolog (S. cerevisiae) Neighboring gene calcium/calmodulin-dependent protein kinase II, beta Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:5900191-5900374 Neighboring gene STARR-positive B cell enhancer ABC_E11764 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:5917894-5918003 Neighboring gene STARR-seq mESC enhancer starr_28452 Neighboring gene STARR-seq mESC enhancer starr_28454 Neighboring gene ribosomal protein S15A, pseudogene 6 Neighboring gene STARR-positive B cell enhancer ABC_E10663 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:6100447-6100630 Neighboring gene NPC1 like intracellular cholesterol transporter 1 Neighboring gene predicted gene 11401

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identifying key m(6)A-methylated lncRNAs and genes associated with neural tube defects via integrative MeRIP and RNA sequencing analyses. Yang J, et al. Front Genet, 2022. PMID 36482889, Free PMC Article
  2. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
  3. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1068

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to pericentriolar material ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytoplasmic dynein complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
nudC domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363446.2 → NP_001350375.1  nudC domain-containing protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL607152, AL611926
    Conserved Domains (2) summary
    pfam14050
    Location:9 → 67
    Nudc_N; N-terminal conserved domain of Nudc
    cl00175
    Location:186 → 239
    alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.

  2. NM_001419325.1 → NP_001406254.1  nudC domain-containing protein 3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL607152, AL611926
    Related
    ENSMUSP00000123108.2, ENSMUST00000135631.2

  3. NM_001419337.1 → NP_001406266.1  nudC domain-containing protein 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL607152, AL611926

  4. NM_173748.6 → NP_776109.1  nudC domain-containing protein 3 isoform 1

    See identical proteins and their annotated locations for NP_776109.1

    Status: VALIDATED

    Source sequence(s)
    AL607152, AL611926
    Consensus CDS
    CCDS24412.1
    UniProtKB/Swiss-Prot
    Q3TX16, Q5SVV6, Q5SVV7, Q6PFE4, Q6ZPZ2, Q8BL70, Q8BWN3, Q8BWW5, Q8R1N4
    UniProtKB/TrEMBL
    B0FTY3
    Related
    ENSMUSP00000064668.4, ENSMUST00000066496.10
    Conserved Domains (2) summary
    cd06495
    Location:186 → 287
    p23_NUDCD3_like; p23-like NUD (nuclear distribution) C-like domain found in human NUDC domain-containing protein 3 (NUDCD3) and similar proteins. Little is known about the function of the proteins in this subgroup.
    pfam14050
    Location:9 → 67
    Nudc_N; N-terminal conserved domain of Nudc

RNA

  1. NR_185059.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL607152, AL611926

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    6055705..6150190 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R1N4.3 GenPept UniProtKB/Swiss-Prot:Q8R1N4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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