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Tyw3 tRNA-yW synthesizing protein 3 homolog (S. cerevisiae) [ Mus musculus (house mouse) ]

Gene ID: 209584, updated on 5-Mar-2024

Summary

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Official Symbol
Tyw3provided by MGI
Official Full Name
tRNA-yW synthesizing protein 3 homolog (S. cerevisiae)provided by MGI
Primary source
MGI:MGI:2445040
See related
Ensembl:ENSMUSG00000047583 AllianceGenome:MGI:2445040
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5230400J09Rik
Summary
Predicted to enable tRNA methyltransferase activity. Predicted to be involved in tRNA methylation. Predicted to act upstream of or within methylation and tRNA processing. Predicted to be active in cytoplasm. Orthologous to human TYW3 (tRNA-yW synthesizing protein 3 homolog). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 6.8), CNS E11.5 (RPKM 4.0) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 H4; 3 79.24 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (154282157..154302750, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (154576520..154597113, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene voltage-dependent anion channel 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_09339 Neighboring gene predicted gene, 40186 Neighboring gene STARR-positive B cell enhancer ABC_E9581 Neighboring gene STARR-seq mESC enhancer starr_09341 Neighboring gene STARR-positive B cell enhancer ABC_E4607 Neighboring gene crystallin, zeta Neighboring gene STARR-seq mESC enhancer starr_09345 Neighboring gene STARR-seq mESC enhancer starr_09346 Neighboring gene predicted gene 20389 Neighboring gene glutamate rich 3 Neighboring gene TNNI3 interacting kinase Neighboring gene STARR-seq mESC enhancer starr_09349 Neighboring gene leucine rich repeat containing 4 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Yin Yang 1 sustains biosynthetic demands during brain development in a stage-specific manner. Zurkirchen L, et al. Nat Commun, 2019 May 16. PMID 31097699, Free PMC Article
  2. Viral Infection-Induced Differential Expression of LncRNAs Associated with Collagen in Mouse Placentas and Amniotic Sacs. Pan J, et al. Am J Reprod Immunol, 2015 Sep. PMID 26073538
  3. The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery. Baines K, et al. Autophagy Rep, 2022. PMID 35449600, Free PMC Article
  4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Hein MY, et al. Cell, 2015 Oct 22. PMID 26496610

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within tRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in wybutosine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tRNA wybutosine-synthesizing protein 3 homolog
Names
tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase
tRNA-yW-synthesizing protein 3
NP_001161830.1
NP_766062.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168358.2 → NP_001161830.1  tRNA wybutosine-synthesizing protein 3 homolog isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1. Variant 2 has an in-frame upstream AUG with a strong Kozak signal but the CDS was annotated at the downstream AUG because the uAUG is only four nucleotides from the predicted transcription start site.
    Source sequence(s)
    AC164292
    UniProtKB/TrEMBL
    E9PYE2
    Related
    ENSMUSP00000131461.2, ENSMUST00000170461.8
    Conserved Domains (1) summary
    pfam02676
    Location:10 → 142
    TYW3; Methyltransferase TYW3

  2. NM_172474.6 → NP_766062.1  tRNA wybutosine-synthesizing protein 3 homolog isoform 1

    See identical proteins and their annotated locations for NP_766062.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Variant 1 has an in-frame upstream AUG with a strong Kozak signal but the CDS was annotated at the downstream AUG because the uAUG is only four nucleotides from the predicted transcription start site.
    Source sequence(s)
    AC164292
    Consensus CDS
    CCDS38680.1
    UniProtKB/Swiss-Prot
    Q8BSA9, Q8BSX2
    UniProtKB/TrEMBL
    B2RUA6
    Related
    ENSMUSP00000057828.2, ENSMUST00000052774.8
    Conserved Domains (1) summary
    pfam02676
    Location:10 → 193
    TYW3; Methyltransferase TYW3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    154282157..154302750 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_375504.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BSA9.1 GenPept UniProtKB/Swiss-Prot:Q8BSA9

Gene LinkOut

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