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Enpp3 ectonucleotide pyrophosphatase/phosphodiesterase 3 [ Mus musculus (house mouse) ]

Gene ID: 209558, updated on 5-Mar-2024

Summary

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Official Symbol
Enpp3provided by MGI
Official Full Name
ectonucleotide pyrophosphatase/phosphodiesterase 3provided by MGI
Primary source
MGI:MGI:2143702
See related
Ensembl:ENSMUSG00000019989 AllianceGenome:MGI:2143702
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CD203c
Summary
Enables nucleoside-triphosphate diphosphatase activity. Involved in several processes, including basophil activation involved in immune response; negative regulation of mast cell activation involved in immune response; and negative regulation of mast cell proliferation. Located in external side of plasma membrane. Orthologous to human ENPP3 (ectonucleotide pyrophosphatase/phosphodiesterase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in small intestine adult (RPKM 19.3), duodenum adult (RPKM 14.8) and 14 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 A4; 10 12.26 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (24649712..24712093, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (24773814..24836195, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene 15270 Neighboring gene cellular communication network factor 2 Neighboring gene STARR-seq mESC enhancer starr_26082 Neighboring gene ectonucleotide pyrophosphatase/phosphodiesterase 1 Neighboring gene STARR-seq mESC enhancer starr_26086 Neighboring gene STARR-seq mESC enhancer starr_26088 Neighboring gene STARR-seq mESC enhancer starr_26089 Neighboring gene STARR-seq mESC enhancer starr_26090 Neighboring gene STARR-positive B cell enhancer ABC_E6826 Neighboring gene mediator complex subunit 23 Neighboring gene predicted gene, 23410 Neighboring gene microRNA 6905

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. E-NPP3 controls plasmacytoid dendritic cell numbers in the small intestine. Furuta Y, et al. PLoS One, 2017. PMID 28225814, Free PMC Article
  2. The ectoenzyme E-NPP3 negatively regulates ATP-dependent chronic allergic responses by basophils and mast cells. Tsai SH, et al. Immunity, 2015 Feb 17. PMID 25692702
  3. Identification of ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3) as a regulator of N-acetylglucosaminyltransferase GnT-IX (GnT-Vb). Korekane H, et al. J Biol Chem, 2013 Sep 27. PMID 23960081, Free PMC Article
  4. Extracellular pyrophosphate metabolism and calcification in vascular smooth muscle. Villa-Bellosta R, et al. Am J Physiol Heart Circ Physiol, 2011 Jul. PMID 21490328, Free PMC Article
  5. Maternal hypervitaminosis D reduces fetal bone mass and mineral acquisition and leads to neonatal lethality. Lieben L, et al. Bone, 2013 Nov. PMID 23895994

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC6548

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleoside triphosphate diphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleoside triphosphate diphosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables nucleoside triphosphate diphosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphodiesterase I activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in ATP metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ATP metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in basophil activation involved in immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of mast cell activation involved in immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of mast cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleoside triphosphate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleoside triphosphate catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphate ion homeostasis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphate-containing compound metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in pyrimidine nucleotide metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ectonucleotide pyrophosphatase/phosphodiesterase family member 3
Names
E-NPP 3
PD-Ibeta
phosphodiesterase I beta
phosphodiesterase I/nucleotide pyrophosphatase 3
NP_598766.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_134005.2 → NP_598766.2  ectonucleotide pyrophosphatase/phosphodiesterase family member 3

    See identical proteins and their annotated locations for NP_598766.2

    Status: VALIDATED

    Source sequence(s)
    AK132256, BB400671
    Consensus CDS
    CCDS23752.1
    UniProtKB/Swiss-Prot
    E9QMU8, Q6DYE8
    Related
    ENSMUSP00000020169.8, ENSMUST00000020169.9
    Conserved Domains (4) summary
    smart00201
    Location:50 → 93
    SO; Somatomedin B -like domains
    smart00477
    Location:627 → 856
    NUC; DNA/RNA non-specific endonuclease
    pfam01663
    Location:161 → 485
    Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
    cd16018
    Location:159 → 525
    Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    24649712..24712093 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_145372.1: Suppressed sequence

    Description
    NM_145372.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6DYE8.2 GenPept UniProtKB/Swiss-Prot:Q6DYE8

Gene LinkOut

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