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Gpkow G patch domain and KOW motifs [ Mus musculus (house mouse) ]

Gene ID: 209416, updated on 5-Mar-2024

Summary

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Official Symbol
Gpkowprovided by MGI
Official Full Name
G patch domain and KOW motifsprovided by MGI
Primary source
MGI:MGI:1859610
See related
Ensembl:ENSMUSG00000031148 AllianceGenome:MGI:1859610
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
T54; DXImx41e; 4432411B18; DXErtd697e
Summary
Predicted to enable RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in nucleoplasm. Predicted to be part of spliceosomal complex. Orthologous to human GPKOW (G-patch domain and KOW motifs). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 6.4), CNS E14 (RPKM 5.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
X A1.1; X 3.47 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (7563373..7576500)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (7697134..7710261)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene MAGI family member, X-linked Neighboring gene peptidylprolyl isomerase A pseudogene x_14.1 Neighboring gene STARR-seq mESC enhancer starr_46667 Neighboring gene STARR-seq mESC enhancer starr_46668 Neighboring gene STARR-seq mESC enhancer starr_46669 Neighboring gene WD repeat domain 45 Neighboring gene PRA1 domain family 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MOS2, a protein containing G-patch and KOW motifs, is essential for innate immunity in Arabidopsis thaliana. Zhang Y, et al. Curr Biol, 2005 Nov 8. PMID 16271871
  2. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Brunkow ME, et al. Nat Genet, 2001 Jan. PMID 11138001
  3. A transcript map of a 2-Mb BAC contig in the proximal portion of the mouse X chromosome and regional mapping of the scurfy mutation. Means GD, et al. Genomics, 2000 May 1. PMID 10857745
  4. Assembly, verification, and initial annotation of the NIA mouse 7.4K cDNA clone set. VanBuren V, et al. Genome Res, 2002 Dec. PMID 12466305, Free PMC Article
  5. ATG5 is required for B cell polarization and presentation of particulate antigens. Arbogast F, et al. Autophagy, 2019 Feb. PMID 30196744, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC159038

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of spliceosomal complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
G-patch domain and KOW motifs-containing protein
Names
g patch domain and KOW motifs-containing protein
protein MOS2 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173747.3 → NP_776108.2  G-patch domain and KOW motifs-containing protein

    See identical proteins and their annotated locations for NP_776108.2

    Status: VALIDATED

    Source sequence(s)
    AK028433, BC092224, BC120679, BI076639, BY074098, CK333382
    Consensus CDS
    CCDS29969.2
    UniProtKB/Swiss-Prot
    A0JLW7, A2AEU7, Q56A08, Q6P5V0, Q8C1C3
    Related
    ENSMUSP00000076178.6, ENSMUST00000049896.13
    Conserved Domains (3) summary
    cd13152
    Location:244 → 298
    KOW_GPKOW_A; KOW motif of the "G-patch domain and KOW motifs-containing protein" (GPKOW) repeat A
    cd13153
    Location:431 → 481
    KOW_GPKOW_B; KOW motif of the "G-patch domain and KOW motifs-containing protein" (GPKOW) repeat B
    pfam12656
    Location:154 → 211
    G-patch_2; DExH-box splicing factor binding site

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    7563373..7576500
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q56A08.2 GenPept UniProtKB/Swiss-Prot:Q56A08

Gene LinkOut

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