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Suv39h1 suppressor of variegation 3-9 1 [ Mus musculus (house mouse) ]

Gene ID: 20937, updated on 16-Apr-2024

Summary

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Official Symbol
Suv39h1provided by MGI
Official Full Name
suppressor of variegation 3-9 1provided by MGI
Primary source
MGI:MGI:1099440
See related
Ensembl:ENSMUSG00000039231 AllianceGenome:MGI:1099440
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mIS6; KMT1A; DXHXS7466e; H3-K9-HMTase 1
Summary
Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and histone methyltransferase activity (H3-K9 specific). Involved in histone H3-K9 methylation; negative regulation of circadian rhythm; and negative regulation of transcription, DNA-templated. Acts upstream of or within several processes, including blastocyst hatching; positive regulation of histone H3-K9 trimethylation; and regulation of cellular response to stress. Located in heterochromatin and nucleus. Part of chromatin silencing complex. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; integumental system; and nervous system. Orthologous to human SUV39H1 (SUV39H1 histone lysine methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 16.1), CNS E11.5 (RPKM 15.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Suv39h1 in Genome Data Viewer
Location:
X A1.1; X 3.64 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (7927401..7940994, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (8061171..8074760, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene ribosomal protein L22, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_46686 Neighboring gene ribosomal protein S29 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7685 Neighboring gene Wiskott-Aldrich syndrome Neighboring gene STARR-seq mESC enhancer starr_46687 Neighboring gene proteasome (prosome, macropain) subunit, beta type 7 pseudogene Neighboring gene proteasome (prosome, macropain) subunit, beta type 7, pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The histone methyltransferase Suv39h regulates 3T3-L1 adipogenesis. Jing J, et al. Adipocyte, 2020 Dec. PMID 32698678, Free PMC Article
  2. Histone methyltransferase SUV39H1 participates in host defense by methylating mycobacterial histone-like protein HupB. Yaseen I, et al. EMBO J, 2018 Jan 17. PMID 29170282, Free PMC Article
  3. p38α MAPK disables KMT1A-mediated repression of myogenic differentiation program. Chatterjee B, et al. Skelet Muscle, 2016. PMID 27551368, Free PMC Article
  4. Altered telomere homeostasis and resistance to skin carcinogenesis in Suv39h1 transgenic mice. Petti E, et al. Cell Cycle, 2015. PMID 25789788, Free PMC Article
  5. Replication stress and chromatin context link ATM activation to a role in DNA replication. Olcina MM, et al. Mol Cell, 2013 Dec 12. PMID 24268576, Free PMC Article

See all (123) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Histone methyltransferase Suv39h1 regulates hepatic stellate cell activation and is targetable in liver fibrosis.
    Title: Histone methyltransferase Suv39h1 regulates hepatic stellate cell activation and is targetable in liver fibrosis.
  2. Suv39h1 contributes to activation of hepatic stellate cells in non-alcoholic fatty liver disease by enabling anaerobic glycolysis.
    Title: Suv39h1 contributes to activation of hepatic stellate cells in non-alcoholic fatty liver disease by enabling anaerobic glycolysis.
  3. The Wnt-pathway corepressor TLE3 interacts with the histone methyltransferase KMT1A to inhibit differentiation in Rhabdomyosarcoma.
    Title: The Wnt-pathway corepressor TLE3 interacts with the histone methyltransferase KMT1A to inhibit differentiation in Rhabdomyosarcoma.
  4. Suv39h1 Silencing Recovers Memory Decline in Scopolamine-Induced Amnesic Mouse Model.
    Title: Suv39h1 Silencing Recovers Memory Decline in Scopolamine-Induced Amnesic Mouse Model.
  5. SUV39H1 Ablation Enhances Long-term CAR T Function in Solid Tumors.
    Title: SUV39H1 Ablation Enhances Long-term CAR T Function in Solid Tumors.
  6. Aging-related decrease of histone methyltransferase SUV39H1 in adipose-derived stem cells enhanced SASP.
    Title: Aging-related decrease of histone methyltransferase SUV39H1 in adipose-derived stem cells enhanced SASP.
  7. SUV39H1 Inhibits Angiogenesis in Limb Ischemia of Mice.
    Title: SUV39H1 Inhibits Angiogenesis in Limb Ischemia of Mice.
  8. OCT4 activates a Suv39h1-repressive antisense lncRNA to couple histone H3 Lysine 9 methylation to pluripotency.
    Title: OCT4 activates a Suv39h1-repressive antisense lncRNA to couple histone H3 Lysine 9 methylation to pluripotency.
  9. Suv39h1 regulates memory stability by inhibiting the expression of Shank1 in hippocampal newborn neurons.
    Title: Suv39h1 regulates memory stability by inhibiting the expression of Shank1 in hippocampal newborn neurons.
  10. The histone methyltransferase Suv39h regulates 3T3-L1 adipogenesis.
    Title: The histone methyltransferase Suv39h regulates 3T3-L1 adipogenesis.
Submit: New GeneRIF Correction See all GeneRIFs (46)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables S-adenosylmethionine-dependent methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone H3K9 methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H3K9 methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H3K9 methyltransferase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables histone H3K9 methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables histone H3K9 methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone H3K9 trimethyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone H3K9me2 methyltransferase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables histone H3K9me2 methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables histone methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein methyltransferase activity TAS
Traceable Author Statement
more info
 PubMed 
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within blastocyst hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to glucose starvation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chromosome organization TAS
Traceable Author Statement
more info
 PubMed 
involved_in circadian rhythm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within determination of adult lifespan IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in energy homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in epigenetic programming in the zygotic pronuclei ISO
Inferred from Sequence Orthology
more info
  
involved_in heterochromatin formation TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of gene expression, epigenetic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in rDNA heterochromatin formation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within rRNA processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of DNA repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of bone mineralization IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of cellular senescence IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of multicellular organism growth IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of transcription by glucose ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of chromatin silencing complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of chromatin silencing complex ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
part_of eNoSc complex ISO
Inferred from Sequence Orthology
more info
  
part_of heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 
part_of heterochromatin ISO
Inferred from Sequence Orthology
more info
  
part_of heterochromatin TAS
Traceable Author Statement
more info
 PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of rDNA heterochromatin ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
histone-lysine N-methyltransferase SUV39H1
Names
Suv39h histone methyltransferase
histone H3-K9 methyltransferase 1
position-effect variegation 3-9 homolog
su(var)3-9 homolog 1
suppressor of variegation 3-9 homolog 1
NP_001277645.1
NP_001345166.1
NP_035644.1
XP_006527637.1
XP_011245754.1
XP_030107150.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290716.3 → NP_001277645.1  histone-lysine N-methyltransferase SUV39H1 isoform 2

    See identical proteins and their annotated locations for NP_001277645.1

    Status: VALIDATED

    Source sequence(s)
    AL663032
    Consensus CDS
    CCDS72337.1
    UniProtKB/TrEMBL
    A2AC19
    Related
    ENSMUSP00000111300.2, ENSMUST00000115637.8
    Conserved Domains (3) summary
    smart00468
    Location:133 → 228
    PreSET; N-terminal to some SET domains
    smart00317
    Location:244 → 367
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam00385
    Location:45 → 92
    Chromo; Chromo (CHRromatin Organization MOdifier) domain

  2. NM_001358237.2 → NP_001345166.1  histone-lysine N-methyltransferase SUV39H1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL663032

  3. NM_011514.3 → NP_035644.1  histone-lysine N-methyltransferase SUV39H1 isoform 1

    See identical proteins and their annotated locations for NP_035644.1

    Status: VALIDATED

    Source sequence(s)
    AL663032
    Consensus CDS
    CCDS40846.1
    UniProtKB/Swiss-Prot
    O54864, Q3TEW2, Q3UT51, Q8C2L3, Q9JLC7, Q9JLP8
    Related
    ENSMUSP00000111301.4, ENSMUST00000115638.10
    Conserved Domains (3) summary
    smart00468
    Location:132 → 227
    PreSET; N-terminal to some SET domains
    smart00317
    Location:243 → 366
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam00385
    Location:44 → 91
    Chromo; Chromo (CHRromatin Organization MOdifier) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    7927401..7940994 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251290.1 → XP_030107150.1  histone-lysine N-methyltransferase SUV39H1 isoform X3

    Conserved Domains (2) summary
    cd18639
    Location:43 → 91
    CD_SUV39H1_like; chromodomain of histone methyltransferase SUV39H1, and similar proteins
    cd10525
    Location:158 → 415
    SET_SUV39H1; SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 1 (SUV39H1) and similar proteins

  2. XM_006527574.5 → XP_006527637.1  histone-lysine N-methyltransferase SUV39H1 isoform X2

    Conserved Domains (2) summary
    cd18639
    Location:43 → 91
    CD_SUV39H1_like; chromodomain of histone methyltransferase SUV39H1, and similar proteins
    cl40432
    Location:158 → 371
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily

  3. XM_011247452.4 → XP_011245754.1  histone-lysine N-methyltransferase SUV39H1 isoform X1

    Conserved Domains (2) summary
    cd18639
    Location:44 → 92
    CD_SUV39H1_like; chromodomain of histone methyltransferase SUV39H1, and similar proteins
    cl40432
    Location:159 → 372
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O54864.1 GenPept UniProtKB/Swiss-Prot:O54864

Gene LinkOut

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